Results 111 to 120 of about 15,195 (308)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Microvesicles in disease

, 2014
On activation cells shed vesicles from their surface by the process of ectocytosis. These micro-vesicles or Ectosomes express phosphatidyl-serine (PS) on their surface, which can elicit a range of biological effects from immune-suppression to the activation of the clotting and complement pathways.
openaire   +3 more sources

Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation.

Blood, 2018
It is currently unclear why agonist-stimulated platelets require shear force to efficiently externalize the procoagulant phospholipid phosphatidylserine (PS) and release PS-exposed microvesicles (MVs).
Aiming Pang, Aiming Pang, Yujie Cui, Yujie Cui, Yunfeng Chen, Ni Cheng, M. K. Delaney, M. Gu, Aleksandra Stojanovic-Terpo, C. Zhu, Xiaoping Du   +10 more
semanticscholar   +1 more source

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

Extracellular vesicles in multiple sclerosis: what are they telling us?

Frontiers in Cellular Neuroscience, 2014
Extracellular vesicles (EVs) are membrane-bound particles secreted by almost all cell types. They are classified depending on their biogenesis and size into exosomes and microvesicles or according to their cell origin.
Matías eSáenz-Cuesta, Matías eSáenz-Cuesta, Iñaki eOsorio-Querejeta, Iñaki eOsorio-Querejeta, David eOtaegui, David eOtaegui   +5 more
doaj   +1 more source

Acoustic Purification of Extracellular Microvesicles [PDF]

ACS Nano, 2015
Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in sample preparation, particularly when sample volumes are small.
Lee, Kyungheon, Shao, Huilin, Weissleder, Ralph, Lee, Hakho   +3 more
openaire   +4 more sources

Distinct Pathogenesis of Pancreatic Cancer Microvesicle–Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— Cancer patients are at high risk of developing deep venous thrombosis (DVT) and venous thromboembolism, a leading cause of mortality in this population.
K. Stark, I. Schubert, U. Joshi, B. Kilani, P. Hoseinpour, M. Thakur, Petra Grünauer, S. Pfeiler, Tobias Schmidergall, Sven Stockhausen, Markus Bäumer, S. Chandraratne, Marie-Luise von Brühl, M. Lorenz, R. Coletti, S. Reese, I. Laitinen, S. Wörmann, H. Algül, C. Bruns, J. Ware, N. Mackman, B. Engelmann, S. Massberg   +23 more
semanticscholar   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

Frontiers in Immunology, 2018
Inflammatory lung responses are one of the characterized features in the pathogenesis of many lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD).
Heedoo Lee, Eric Abston, Duo Zhang, Ashish Rai, Yang Jin   +4 more
doaj   +1 more source

Platelet Microvesicles (Microparticles) in Cardiac Surgery [PDF]

Journal of Cardiothoracic and Vascular Anesthesia, 2016
SIGNIFICANT POSTOPERATIVE BLEEDING is a common risk of cardiac surgery, with approximately 3.5% of patients requiring surgical re-exploration.1 Re-exploration is associated with adverse outcomes, including infections, ischemia, and increased 30-day mortality.2 Similar adverse outcomes are related to erythrocyte transfusions associated with cardiac ...
Tempo, Jake, Englyst, Nicola A., Holloway, Judith A., Smith, David C.   +3 more
openaire   +5 more sources