Results 21 to 30 of about 18,155 (253)

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Biotechnology Journal, 2021
Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiation and ...
Lu Luo, N. Foster, Kenny Man, Mathieu Y. Brunet, D. Hoey, S. Cox, S. Kimber, A. E. Haj   +7 more
semanticscholar   +1 more source

Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study

Biomolecules, 2023
Cerebrospinal fluid (CSF) is a biochemical–clinical window into the brain. Unfortunately, its wide dynamic range, low protein concentration, and small sample quantity significantly limit the possibility of using it routinely.
Xhuliana Kajana, Sonia Spinelli, Andrea Garbarino, Ganna Balagura, Martina Bartolucci, Andrea Petretto, Marco Pavanello, Giovanni Candiano, Isabella Panfoli, Maurizio Bruschi   +9 more
doaj   +1 more source

Endothelial cells release microvesicles that harbour multivesicular bodies and secrete exosomes

Journal of Extracellular Biology, 2023
Extracellular vesicles (EVs) released by endothelial cells support vascular homeostasis. To better understand endothelial cell EV biogenesis, we examined cultured human umbilical vein endothelial cells (HUVECs) prepared by rapid freezing, freeze ...
Jennifer D. Petersen, Elena Mekhedov, Sukhbir Kaur, David D. Roberts, Joshua Zimmerberg   +4 more
doaj   +1 more source

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

Frontiers in Aging Neuroscience, 2021
IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau.
Janine Utz, Judith Berner, Luis Enrique Muñoz, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer   +9 more
doaj   +1 more source

Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method

Journal of Extracellular Vesicles, 2022
The development of a new large‐scale purification protocol is required for research on the reliable bioactivity and drug discovery of extracellular vesicles (EVs).
Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Hiroaki Tateno, Asako Shimoda, Takanori Ichiki, Koichi Furukawa, Jun Hirabayashi, Kazunari Akiyoshi, Hiroshi Shiku   +9 more
doaj   +1 more source

Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences

Proteomes, 2020
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions ...
Joames K. Freitas Leal, Edwin Lasonder, Vikram Sharma, Jürgen Schiller, Giuseppina Fanelli, Sara Rinalducci, Roland Brock, Giel Bosman   +7 more
doaj   +1 more source

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

BMC Cancer, 2012
Background RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients.
Noerholm Mikkel, Balaj Leonora, Limperg Tobias, Salehi Afshin, Zhu Lin, Hochberg Fred H, Breakefield Xandra O, Carter Bob S, Skog Johan   +8 more
doaj   +1 more source

Microvesicle Formation Induced by Oxidative Stress in Human Erythrocytes

Antioxidants, 2020
Extracellular vesicles (EVs) released by different cell types play an important role in many physiological and pathophysiological processes. In physiological conditions, red blood cell (RBC)-derived EVs compose 4–8% of all circulating EVs, and oxidative ...
Julia S. Sudnitsyna, E. Skverchinskaya, I. Dobrylko, E. Nikitina, S. Gambaryan, I. Mindukshev   +5 more
semanticscholar   +1 more source

Nanoscale Phytosomes as an Emerging Modality for Cancer Therapy

Cells, 2023
Extracellular vesicle (EV) research has expanded substantially over the years. EVs have been identified in all living organisms and are produced and released as a means of intercellular communication or as a defense mechanism.
Ahmad Kadriya, Mizied Falah
doaj   +1 more source

Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy

Journal of Diabetes Research, 2017
Aims. To investigate how circulating microvesicle phenotypes correlate with insulin sensitivity, body composition, plasma lipids, and hepatic fat accumulation.
Jaco Botha, Line Velling Magnussen, Morten Hjuler Nielsen, Tine Bo Nielsen, Kurt Højlund, Marianne Skovsager Andersen, Aase Handberg   +6 more
doaj   +1 more source