Results 1 to 10 of about 6,918 (134)

Midkine promotes PDGF‐BB‐induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathway [PDF]

Physiological Reports
Airway smooth muscle cell (ASMC) dysfunction drives airway remodeling in asthma, yet the molecular mediators remain incompletely defined. Midkine, a pleiotropic growth factor, has emerged as a potential regulator of inflammatory and proliferative ...
Yongtian Xu, Wenli Li, Jun Shi, Yanfang Guo   +3 more
doaj   +2 more sources

Premenopausal serum midkine levels and risk of estrogen receptor positive breast cancer: a prospective, nested case–control study [PDF]

Breast Cancer Research
Background Midkine is a heparin-binding growth factor that is overexpressed in most human malignancies, including breast cancer. While elevated midkine levels have been associated with tumor progression and aging, its role as a predictive biomarker for ...
Pengze Yan, Fen Wu, Yelena Afanasyeva, Alan Arslan, Karen Koenig, Anne Zeleniuch-Jacquotte, Yu Chen, Kornelia Polyak   +7 more
doaj   +2 more sources

Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina [PDF]

Neural Development, 2012
Background Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb).
Luo Jing, Uribe Rosa A, Hayton Sarah, Calinescu Anda-Alexandra, Gross Jeffrey M, Hitchcock Peter F   +5 more
doaj   +3 more sources

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation [PDF]

Advanced Science
Stress is an established trigger of skin inflammation and disease flares; however, the mechanisms have remained unclear. Here, using human data, mechanistic exploration, and single‐cell RNA sequencing in mouse models of skin inflammation under stress ...
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
doaj   +2 more sources

A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche [PDF]

Cell Regeneration
The interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC ...
Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen   +12 more
doaj   +2 more sources

Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value [PDF]

Libyan Journal of Medicine
To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of
Lin Gao, Qindi Liu, Zhiming Kuang, Shanbin Yuan   +3 more
doaj   +2 more sources

Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis [PDF]

Biomedicines
Background/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear.
Suna Aydin, İsmail Polat, Kevser Tural, Nurullah Duger, Kader Ugur, İbrahim Sahin, Suleyman Aydin, Do-Youn Lee   +7 more
doaj   +2 more sources

Multi-Component Analysis of Protein- and DNA-Coated Magnetic Nanoparticles Using Electrochemical Impedance Spectroscopy with Interdigitated Electrode Sensors [PDF]

Bioengineering
The characterization of cancer and other diseases can be aided by the development of reusable electrochemical sensors that provide broad biomarker expression information in real time. We describe an interdigitated electrode (IDE) sensor array that can be
Kestley Lutey, Patrick B. White, Hiram Cammon, Miranda Trester, Sue Brumfield, John J. Neumeier, Seth Pincus, Robert W. Haushalter, Joshua Heinemann   +8 more
doaj   +2 more sources

Midkine Serum Levels in Inflammatory and Non-Inflammatory Dilated Cardiomyopathy [PDF]

Biomedicines
Objectives: This retrospective study examines midkine, an inflammatory cytokine, as a potential serological biomarker to distinguish dilated cardiomyopathy (DCM) and inflammatory dilated cardiomyopathy (DCMi).
Ulrich Grabmaier, Bartolo Ferraro, Kristin Lehnert, Astrid Petersmann, Stephan B. Felix, Ludwig T. Weckbach   +5 more
doaj   +2 more sources

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions [PDF]

Frontiers in Genetics
Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors.
María Aránzazu Penedo, María Aránzazu Penedo, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Esther Gramage, Esther Gramage, Esther Gramage, Gonzalo Herradón, Gonzalo Herradón, Gonzalo Herradón   +9 more
doaj   +2 more sources