Results 11 to 20 of about 6,987 (195)

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus. Methods We examined midkine mRNA expression and midkine protein expression by seven human pancreatic ...
Ito Tatsuo, Nagai Kazuyuki, Kida Atsushi, Koizumi Masayuki, Ito Daisuke, Mori Tomohiko, Kami Kazuhiro, Doi Ryuichiro, Toyoda Eiji, Masui Toshihiko, Wada Michihiko, Tagawa Masatoshi, Uemoto Shinji   +12 more
doaj   +3 more sources

Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches [PDF]

European Journal of Breast Health
Midkine (MDK) is a protein that contributes to both physiological and pathological processes. Several studies provide insight into the different roles of MDK in development, tissue repair, neural plasticity, and health and disease processes.
Berna Yıldırım, Kudret Kulak, Ayhan Bilir   +2 more
doaj   +2 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources

Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To evaluate the effect of midkine on lipopolysaccharide (LPS)-induced airway smooth muscle cells (ASMCs). Methods: LPS-stimulated acute lung injury model was used to analyze the effect of midkine on ASMCs in vitro.
Qi-Feng Huang, Bo Wang, Yu-Qing Weng, Tang Deng, Li-Hua Li, Jin Qian, Qi Li, Kai-Wen Lin, Dong-Mei Sun, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Yuan-Tian Sun, Xiao-Ran Liu   +13 more
doaj   +1 more source

Pulmonary midkine inhibition ameliorates sepsis induced lung injury

Journal of Translational Medicine, 2021
Background Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) system, as well as the mechanism by ...
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang   +4 more
doaj   +1 more source

Midkine-Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury. [PDF]

Adv Sci (Weinh)
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Lu L, Liu B, Yang Y, Meng T, Chang Y, Peng Y, Guo J, Wang Z, Guo H, Zhou L, Zhao X.   +10 more
europepmc   +2 more sources

Midkine inhibition enhances anti-PD-1 immunotherapy in sorafenib-treated hepatocellular carcinoma via preventing immunosuppressive MDSCs infiltration

Cell Death Discovery, 2023
Sorafenib, a multiple-target tyrosine kinase inhibitor, is the standard of care for patients with advanced hepatocellular carcinoma (HCC), but provides limited benefits.
Lijuan Ding, Nanya Wang, Qiang Wang, Xia Fan, Yuning Xin, Shudong Wang   +5 more
doaj   +1 more source

Midkine in host defence [PDF]

British Journal of Pharmacology, 2014
Midkine (MK) shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin‐binding regions and effects on immune cells, such as recruitment and activation of neutrophils and macrophages.
A, Gela, S, Jovic, S L, Nordin, A, Egesten   +3 more
openaire   +2 more sources

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]

, 2017
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S., Gonias, Steven L., Karimi-Mostowfi, Nicki, Mantuano, Elisabetta, Murray, Sarah S.   +4 more
core   +13 more sources

Midkine in Inflammation

The Scientific World JOURNAL, 2011
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and ...
Ludwig T. Weckbach, Takashi Muramatsu, Barbara Walzog   +2 more
openaire   +4 more sources