Results 11 to 20 of about 6,907 (199)

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus. Methods We examined midkine mRNA expression and midkine protein expression by seven human pancreatic ...
Ito Tatsuo, Nagai Kazuyuki, Kida Atsushi, Koizumi Masayuki, Ito Daisuke, Mori Tomohiko, Kami Kazuhiro, Doi Ryuichiro, Toyoda Eiji, Masui Toshihiko, Wada Michihiko, Tagawa Masatoshi, Uemoto Shinji   +12 more
doaj   +3 more sources

Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To evaluate the effect of midkine on lipopolysaccharide (LPS)-induced airway smooth muscle cells (ASMCs). Methods: LPS-stimulated acute lung injury model was used to analyze the effect of midkine on ASMCs in vitro.
Qi-Feng Huang, Bo Wang, Yu-Qing Weng, Tang Deng, Li-Hua Li, Jin Qian, Qi Li, Kai-Wen Lin, Dong-Mei Sun, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Yuan-Tian Sun, Xiao-Ran Liu   +13 more
doaj   +1 more source

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources

Pulmonary midkine inhibition ameliorates sepsis induced lung injury

Journal of Translational Medicine, 2021
Background Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) system, as well as the mechanism by ...
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang   +4 more
doaj   +1 more source

Midkine inhibition enhances anti-PD-1 immunotherapy in sorafenib-treated hepatocellular carcinoma via preventing immunosuppressive MDSCs infiltration

Cell Death Discovery, 2023
Sorafenib, a multiple-target tyrosine kinase inhibitor, is the standard of care for patients with advanced hepatocellular carcinoma (HCC), but provides limited benefits.
Lijuan Ding, Nanya Wang, Qiang Wang, Xia Fan, Yuning Xin, Shudong Wang   +5 more
doaj   +1 more source

Midkine in host defence [PDF]

British Journal of Pharmacology, 2014
Midkine (MK) shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin‐binding regions and effects on immune cells, such as recruitment and activation of neutrophils and macrophages.
A, Gela, S, Jovic, S L, Nordin, A, Egesten   +3 more
openaire   +2 more sources

Midkine in Inflammation

The Scientific World JOURNAL, 2011
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and ...
Ludwig T. Weckbach, Takashi Muramatsu, Barbara Walzog   +2 more
openaire   +4 more sources

Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data

Frontiers in Genetics, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying molecular ...
Shichen Zhang, Lanlan Zhang, Lu Wang, Hongqiu Wang, Jiaxin Wu, Haoyang Cai, Chunheng Mo, Jian Yang   +7 more
doaj   +1 more source

Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]

, 2016
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina, Gajdoš, Petr, Kriegová, Eva, Krömer, Pavel, Kudělka, Miloš, Minařík, Jiří, Papajík, Tomáš, Pika, Tomáš, Schneiderová, Petra, Ščudla, Vlastimil   +9 more
core   +1 more source

Midkine’s Role in Cardiac Pathology [PDF]

Journal of Cardiovascular Development and Disease, 2017
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated with acute and chronic pathologic conditions such as myocardial infarction and heart failure (HF ...
Kathleen C. Woulfe, Carmen C. Sucharov
openaire   +3 more sources