Frontiers in Genetics, 2023 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying molecular ...
Shichen Zhang +7 more
doaj +1 more source
Mesenchymal stem cells with overexpression of midkine enhance cell survival and attenuate cardiac dysfunction in a rat model of myocardial infarction [PDF]
, 2014 Introduction. Elevated midkine (MK) expression may contribute to ventricular remodeling and ameliorate cardiac dysfunction after myocardial infarction (MI).
Chen, S.-L. (Shao-Liang) +4 more
core +10 more sources
Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]
, 2016 Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina +9 more
core +1 more source
Midkine’s Role in Cardiac Pathology [PDF]
Journal of Cardiovascular Development and Disease, 2017 Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated with acute and chronic pathologic conditions such as myocardial infarction and heart failure (HF ...
Kathleen C. Woulfe, Carmen C. Sucharov
openaire +3 more sources
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival
BMC Medical Genomics, 2008 Background Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis. However, little is known about the upstream factors and
You Zongbing +5 more
doaj +1 more source
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
core +2 more sources
Monoclonal Antibody to Human Midkine Reveals Increased Midkine Expression in Human Brain Tumors [PDF]
Journal of Neuropathology and Experimental Neurology, 1999 We produced a rat IgG2a monoclonal antibody against the carboxyl terminal region of human midkine (MK), a novel growth factor. This monoclonal antibody was used in immunohistochemical studies to compare the expression of MK, proliferating cell nuclear antigen (PCNA) and p53 protein in 133 primary brain tumors and 21 carcinoma metastases to the central ...
S, Kato +12 more
openaire +2 more sources
Frontiers in Immunology, 2019 Background and Purpose: Post-traumatic cardiac dysfunction often occurs in multiply injured patients (ISS ≥ 16). Next to direct cardiac injury, post-traumatic cardiac dysfunction is mostly induced by the release of inflammatory biomarkers.
Ina Lackner +15 more
doaj +1 more source
The circulating midkine in the newly diagnosed celiac disease: Clinical implications
Advanced Biomedical Research, 2021 Background: Celiac disease (CeD) is a chronic inflammatory small intestine disorder caused by an abnormal immune response to an array of the epitopes of the wheat gluten and related proteins of rye and barley in genetically susceptible individuals ...
Mohammad Hassan Emami +3 more
doaj +1 more source