Results 31 to 40 of about 6,907 (199)

Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives [PDF]

, 2020
Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric ...
Berwian, Brites, Campbell, Heneka, Heras-Sandoval, Kenis, Müller, O'neill, Piirainen, Skaper, Skaper, Weber   +11 more
core   +2 more sources

Estimation of midkine levels in serum and gingival crevicular fluid in smokers and non-smokers of chronic gingivitis patients – A clinico-biochemical study

Journal of Dr. NTR University of Health Sciences, 2018
Objectives: To detect the presence of Midkine in serum and gingival crevicular fluid (GCF) of healthy non-smokers, chronic gingivitis smokers, and non-smoker individuals and to evaluate the role of Midkine in the progression of gingival inflammation ...
Dandu Subramanyam Madhu Babu, Sundeep Narahari, Vineetha Vemuri, Egatela Prasuna, Dandu Siva Sai Prasad Reddy, Nagireddy Ravindra Reddy   +5 more
doaj   +1 more source

The role of midkine in health and disease

Frontiers in Immunology, 2023
Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair.
Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer   +2 more
doaj   +1 more source

Integrating single-cell RNA-seq and spatial transcriptomics reveals MDK-NCL dependent immunosuppressive environment in endometrial carcinoma

Frontiers in Immunology, 2023
ObjectivesThe tumor microenvironment (TME) play important roles in progression of endometrial carcinoma (EC). We aimed to assess the cell populations in TME of EC.MethodsWe downloaded datasets of single-cell RNA-seq (scRNA-seq) and spatial transcriptome (
Xinnian Yu, Linjun Xie, Jianjuan Ge, Huixin Li, Shanliang Zhong, Xiaolin Liu   +5 more
doaj   +1 more source

Midkine mediates intercellular crosstalk between drug-resistant and drug sensitive neuroblastoma cells in vitro and in vivo [PDF]

, 2013
Resistance to cytotoxic agents has long been known to be a major limitation in the treatment of human cancers. Although many mechanisms of drug resistance have been identified, chemotherapies targeting known mechanisms have failed to lead to effective ...
Chou, Pauline M, Chu, Fei, Clark, Sandra, Czurylo, Michael, Holub, Janette L, Lautz, Timothy B, Madonna, Mary Beth, Naiditch, Jessica A, Qiu, Yi-Yong, Zheng, Xin   +9 more
core   +3 more sources

Midkine and multiple sclerosis [PDF]

British Journal of Pharmacology, 2012
Multiple sclerosis (MS) is an autoimmune neurological disease characterized by inflammatory demyelination with subsequent neuronal damage in the CNS. MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have been thought as autoreactive Th1 and Th17 cell‐mediated diseases.
openaire   +2 more sources

Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma [PDF]

, 2013
Background: Proteomic discovery of cancer biomarkers in body fluids is challenging because of their low abundance in a complex background. Altered gene expression in tumours may not reflect protein levels in body fluids.
A Martin, BM Bolstad, C Parr, C Parr, C Wang, C Yu, D G Ward, D Kaufman, D Tilki, E Cauberg, E Orenes-Piñero, Gordon K Smyth, H Kataoka, H Kawanishi, H Onda, I Waldhauer, J Salo, J Wiśniewski, K Chang, K K Cheng, K Nakamura, L Dyrskjøt, L Mengual, M Babjuk, M Grønborg, M Lindén, M Makridakis, M Muramaki, M P Zeegers, M Sánchez-Carbayo, M Volmer, M Yang, MP Zeegers, N Anderson, N D James, N J Shimwell, N James, N Nagaraj, N Yang, O Nagakawa, P J Johnson, R Bryan, R T Bryan, RA Irizarry, S Ikematsu, S Irmak, S Kageyama, S Ray, S Shariat, T O’Brien, W Wei, Y Chang, Y Chen, Y Lotan, Y Senga   +54 more
core   +3 more sources

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3

EBioMedicine, 2018
Midkine is a pleiotropic factor, which is involved in angiogenesis. However, its mode of action in this process is still ill defined. The function of midkine in arteriogenesis, the growth of natural bypasses from pre-existing collateral arteries ...
Thomas Lautz, Manuel Lasch, Julia Borgolte, Kerstin Troidl, Judith-Irina Pagel, Amelia Caballero-Martinez, Eike Christian Kleinert, Barbara Walzog, Elisabeth Deindl   +8 more
doaj   +1 more source

Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish.

PLoS ONE, 2020
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors.
Nicholas B Ang, Alfonso Saera-Vila, Caroline Walsh, Peter F Hitchcock, Alon Kahana, Ryan Thummel, Mikiko Nagashima   +6 more
doaj   +1 more source

Serum midkine concentrations and gastric cancer [PDF]

Cancer Science, 2005
Midkine (MK) is one of a family of heparin‐binding growth factors, and increased MK expression is reported in various types of human carcinomas. To clarify the association between serum MK (S‐MK) concentrations and gastric cancer, we examined S‐MK concentrations of gastric cancer patients (n = 275) and healthy controls (n = 275). S‐MK concentrations of
Yuki, Obata, Shogo, Kikuchi, Yingsong, Lin, Kiyoko, Yagyu, Takashi, Muramatsu, Hideshi, Kumai   +5 more
openaire   +2 more sources