Results 41 to 50 of about 6,907 (199)

Biomarkers for Detecting Kidney Dysfunction in Type-2 Diabetics and Diabetic Nephropathy Subjects: A Case-Control Study to Identify Potential Biomarkers of DN to Stratify Risk of Progression in T2D Patients

open access: yesFrontiers in Endocrinology, 2022
IntroductionCurrently there are no biomarkers that are predictive of when patients with type-2 diabetes (T2D) will progress to more serious kidney disease i.e., diabetic nephropathy (DN).
Carla Harkin   +11 more
doaj   +1 more source

Midkine Deficiency Attenuates Lipopolysaccharide-Induced Pulmonary Inflammation. [PDF]

open access: yesInt J Mol Sci
Midkine (MDK) is a multifunctional heparin-binding growth factor, and has been shown to regulate cell growth, survival and migration. It also plays important roles in several inflammatory diseases such as sepsis. However, the role of MDK in the lungs has not yet been elucidated.
Tanino Y   +8 more
europepmc   +3 more sources

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]

open access: yes, 2017
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S.   +4 more
core   +3 more sources

Evaluation of Cognitive Functions in Hypertensive Patients and Its Relationship with Serum Midkine Levels

open access: yesSakarya Tıp Dergisi, 2017
Objective: Hypertension (HT) is one of the risk factors associated with dementia. Our aim was to research cognitive functions in patients with HT and its relationship to midkine levels in serum.
Eda Celik Guzel   +8 more
doaj   +1 more source

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus [PDF]

open access: yes, 2015
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
González Castillo, Celia   +4 more
core   +2 more sources

MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

open access: yesFrontiers in Physiology, 2017
Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown ...
Niamat Khan   +7 more
doaj   +1 more source

Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling

open access: yesMarine Drugs, 2022
Different classes of phytochemicals were previously isolated from the Red Sea algae Hypnea musciformis as sterols, ketosteroids, fatty acids, and terpenoids. Herein, we report the isolation of three fatty acids—docosanoic acid 4, hexadecenoic acid 5, and
Sameh S. Elhady   +13 more
doaj   +1 more source

Chondroitin sulfates and their binding molecules in the central nervous system [PDF]

open access: yes, 2017
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
Djerbal, L, Kwok, JCF, Lortat-Jacob, H
core   +3 more sources

Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. [PDF]

open access: yes, 2015
In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. In women, menopause is associated with increased risk of memory disturbances, which can be attenuated by timely estrogen therapy.
Annie Rodolosse   +7 more
core   +1 more source

Involvement of midkine in neuroblastoma tumourigenesis [PDF]

open access: yesBritish Journal of Pharmacology, 2014
Midkine is highly expressed in various cancers, including neuroblastoma, one of the most malignant paediatric solid tumours known. Also, it has been shown to be useful as a tumour marker, a prognosis factor and a target of molecular therapy. Several molecular tools (e.g.
S, Kishida, K, Kadomatsu
openaire   +2 more sources

Home - About - Disclaimer - Privacy