Results 41 to 50 of about 6,987 (195)

Midkine Deficiency Attenuates Lipopolysaccharide-Induced Pulmonary Inflammation. [PDF]

Int J Mol Sci
Midkine (MDK) is a multifunctional heparin-binding growth factor, and has been shown to regulate cell growth, survival and migration. It also plays important roles in several inflammatory diseases such as sepsis. However, the role of MDK in the lungs has not yet been elucidated.
Tanino Y, Wang X, Nikaido T, Sato Y, Togawa R, Watanabe N, Tanino M, Kadomatsu K, Shibata Y.   +8 more
europepmc   +3 more sources

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3

EBioMedicine, 2018
Midkine is a pleiotropic factor, which is involved in angiogenesis. However, its mode of action in this process is still ill defined. The function of midkine in arteriogenesis, the growth of natural bypasses from pre-existing collateral arteries ...
Thomas Lautz, Manuel Lasch, Julia Borgolte, Kerstin Troidl, Judith-Irina Pagel, Amelia Caballero-Martinez, Eike Christian Kleinert, Barbara Walzog, Elisabeth Deindl   +8 more
doaj   +1 more source

Biomarkers for Detecting Kidney Dysfunction in Type-2 Diabetics and Diabetic Nephropathy Subjects: A Case-Control Study to Identify Potential Biomarkers of DN to Stratify Risk of Progression in T2D Patients

Frontiers in Endocrinology, 2022
IntroductionCurrently there are no biomarkers that are predictive of when patients with type-2 diabetes (T2D) will progress to more serious kidney disease i.e., diabetic nephropathy (DN).
Carla Harkin, Diego Cobice, Simon Brockbank, Stephanie Bolton, Frances Johnston, Anna Strzelecka, Joanne Watt, Mary Jo Kurth, John V. Lamont, Peter Fitzgerald, Tara Moore, Mark W. Ruddock   +11 more
doaj   +1 more source

Serum midkine concentrations and gastric cancer [PDF]

Cancer Science, 2005
Midkine (MK) is one of a family of heparin‐binding growth factors, and increased MK expression is reported in various types of human carcinomas. To clarify the association between serum MK (S‐MK) concentrations and gastric cancer, we examined S‐MK concentrations of gastric cancer patients (n = 275) and healthy controls (n = 275). S‐MK concentrations of
Yuki, Obata, Shogo, Kikuchi, Yingsong, Lin, Kiyoko, Yagyu, Takashi, Muramatsu, Hideshi, Kumai   +5 more
openaire   +2 more sources

Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish.

PLoS ONE, 2020
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors.
Nicholas B Ang, Alfonso Saera-Vila, Caroline Walsh, Peter F Hitchcock, Alon Kahana, Ryan Thummel, Mikiko Nagashima   +6 more
doaj   +1 more source

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus [PDF]

, 2015
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
González Castillo, Celia, Guzmán-Brambila, Carolina, Ortuño Sahagún, Daniel, Pallàs i Llibería, Mercè, 1964-, Rojas-Mayorquín, Argelia E.   +4 more
core   +2 more sources

Evaluation of Cognitive Functions in Hypertensive Patients and Its Relationship with Serum Midkine Levels

Sakarya Tıp Dergisi, 2017
Objective: Hypertension (HT) is one of the risk factors associated with dementia. Our aim was to research cognitive functions in patients with HT and its relationship to midkine levels in serum.
Eda Celik Guzel, Fatma Behice Serinkan Cinemre, Savas Guzel, Volkan Kuçukyalcin, Ali Riza Kiziler, Coskun Cavusoglu, Tevfik Gulyasar, Hakan Cinemre, Birsen Aydemir   +8 more
doaj   +1 more source

MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

Frontiers in Physiology, 2017
Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown ...
Niamat Khan, Niamat Khan, Lutz Binder, Lutz Binder, D. V. Krishna Pantakani, D. V. Krishna Pantakani, Abdul R. Asif, Abdul R. Asif   +7 more
doaj   +1 more source

Chondroitin sulfates and their binding molecules in the central nervous system [PDF]

, 2017
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
Djerbal, L, Kwok, JCF, Lortat-Jacob, H
core   +3 more sources

Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling

Marine Drugs, 2022
Different classes of phytochemicals were previously isolated from the Red Sea algae Hypnea musciformis as sterols, ketosteroids, fatty acids, and terpenoids. Herein, we report the isolation of three fatty acids—docosanoic acid 4, hexadecenoic acid 5, and
Sameh S. Elhady, Eman S. Habib, Reda F. A. Abdelhameed, Marwa S. Goda, Reem M. Hazem, Eman T. Mehanna, Mohamed A. Helal, Khaled M. Hosny, Reem M. Diri, Hashim A. Hassanean, Amany K. Ibrahim, Enas E. Eltamany, Usama Ramadan Abdelmohsen, Safwat A. Ahmed   +13 more
doaj   +1 more source