Results 51 to 60 of about 6,907 (199)
Midkine can not be accepted as a new biomarker for unexplained female infertility
Türk Biyokimya Dergisi, 2023 This study aimed to investigate whether a growth factor and a cytokine midkine (MK) can be a new biomarker for the diagnosis and treatment of unexplained female infertility (UFI) cases.
Ergüven Mine +3 more
doaj +1 more source
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19
Frontiers in Physiology, 2020 SARS-CoV2 infection not only causes abnormal severe pneumonia but also induces other relevant pathophysiological effects on several tissues and organs.
Giulia Sanino +3 more
doaj +1 more source
Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng +12 more
wiley +1 more source
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter +6 more
core +2 more sources
Antioxidants, 2021 A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched.
Małgorzata Trocha +7 more
doaj +1 more source
Dienogest mediates midkine suppression in endometriosis [PDF]
Human Reproduction, 2016 What are the effects of dienogest (DNG) on midkine (MK) production in women with endometriosis?DNG-mediated down-regulation of MK in vivo and in vitro.DNG is an oral progestin that alleviates painful symptoms of women with endometriosis with a favourable tolerability and safety profile. Its effects on MK, a growth factor that plays an important role in
Nirgianakis, K +5 more
openaire +8 more sources
Advanced Science, EarlyView.Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan +8 more
wiley +1 more source
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Arthritis Research & Therapy, 2018 Background Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic diagnostic biomarker for SSc-PAH would allow for rapid non-invasive screening and ...
Lisa M. Rice +9 more
doaj +1 more source
European Journal of Inflammation, 2020 Midregional pro-adrenomedullin (MR-proADM), midkine, and stromelysin2 (ST2) are novel cardiac biomarkers associated with heart failure and atherosclerotic diseases like stable ischemic disease and acute coronary syndrome.
Zhong Chen, Yawen Zhu, Lili Zhang
doaj +1 more source
Midkine—A novel player in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2022 Midkine (MK) is a 13-kDa heparin-binding cytokine and growth factor with anti-apoptotic, pro-angiogenic, pro-inflammatory and anti-infective functions, that enable it to partake in a series of physiological and pathophysiological processes. In the past, research revolving around MK has concentrated on its roles in reproduction and development, tissue ...
Marina Majaj +4 more
openaire +4 more sources