Results 61 to 70 of about 6,987 (195)
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Midkine—A novel player in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2022 Midkine (MK) is a 13-kDa heparin-binding cytokine and growth factor with anti-apoptotic, pro-angiogenic, pro-inflammatory and anti-infective functions, that enable it to partake in a series of physiological and pathophysiological processes. In the past, research revolving around MK has concentrated on its roles in reproduction and development, tissue ...
Marina Majaj +4 more
openaire +4 more sources
Molecules, 2022 NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation.
Sidra Shahid +5 more
doaj +1 more source
The FEBS Journal, EarlyView.midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen +6 more
wiley +1 more source
ALK activation, ligands and therapeutic targets in glioblastoma and other cancers
Frontiers in Oncology, 2012 The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj +1 more source
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19
Frontiers in Physiology, 2020 SARS-CoV2 infection not only causes abnormal severe pneumonia but also induces other relevant pathophysiological effects on several tissues and organs.
Giulia Sanino +3 more
doaj +1 more source
JCRPE, 2021 Objective:This study aimed to assess the role of serum midkine (MK) as a biomarker for early detection of diabetic nephropathy in children with type 1 diabetes mellitus (T1DM) before microalbuminuria emerges.Methods:A total of 120 children with T1DM ...
Kotb Abbass Metwalley +6 more
doaj +1 more source
Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]
, 2017 BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D +7 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Increased Midkine Expression in Hepatocellular Carcinoma
Archives of Pathology & Laboratory Medicine, 2000 AbstractContext.—Midkine (MK) is a novel heparin-binding growth factor whose gene was identified in embryonal carcinoma cells in early stages of retinoic acid–induced differentiation.Objective.—To examine the overexpression of MK in hepatocellular carcinoma (HCC).Methods.—Seventy-seven primary HCC specimens from patients aged 17 to 72 years (63 men and
M, Kato +4 more
openaire +2 more sources