Results 61 to 70 of about 6,907 (199)

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

Molecules, 2022
NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation.
Sidra Shahid, Marlena Pantakani, Lutz Binder, Andreas Fischer, Krishna Pantakani, Abdul R. Asif   +5 more
doaj   +1 more source

Biomarkers for Hepatocellular Carcinoma [PDF]

, 2017
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The HCC diagnosis is usually achieved by biomarkers, which can also help in prognosis prediction.
Jiang, Shuai, Lou, Jiatao, Lv, Shaogang, Zhang, Chenzi, Zhang, LingFei   +4 more
core   +2 more sources

Comprehensive analysis and functional validation of key genes in bladder cancer progression

VIEW, EarlyView.
Bladder cancer is highly diverse between patients, making it difficult to accurately predict who will have aggressive disease and poor outcomes. In this study, we integrated single‐cell RNA sequencing with clinical survival data to identify a simple three‐gene signature (FAM3B, C10orf99, and VMP1) that stratifies patients into high‐ and low‐risk groups.
Xiaoning Cheng, Hongxia Zhao, Qian Li, Boyang Liu, Maoping Cai, Xinyi Wang, Jiancong Lie, Yuanyuan Qu, Jianwei Li, Chunlong Yang   +9 more
wiley   +1 more source

ALK activation, ligands and therapeutic targets in glioblastoma and other cancers

Frontiers in Oncology, 2012
The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj   +1 more source

Midkine: Utility as a Predictor of Early Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

JCRPE, 2021
Objective:This study aimed to assess the role of serum midkine (MK) as a biomarker for early detection of diabetic nephropathy in children with type 1 diabetes mellitus (T1DM) before microalbuminuria emerges.Methods:A total of 120 children with T1DM ...
Kotb Abbass Metwalley, Hekma Saad Farghaly, Magda Farghali Gabri, Safwat Mohamed Abdel-Aziz, Asmaa Mohamed Ismail, Duaa Mohamed Raafat, Islam Fathy Elnakeeb   +6 more
doaj   +1 more source

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation. [PDF]

, 2016
UNLABELLED: Vascular smooth muscle cells (SMCs) from distinct anatomic locations derive from different embryonic origins. Here we investigated the respective potential of different embryonic origin-specific SMCs derived from human embryonic stem cells ...
Bargehr, Johannes, Bennett, Martin R, Bernard, William G, Cheung, Christine, Gambardella, Laure, Iyer, Dharini, Low, Lucinda, Sinha, Sanjay   +7 more
core   +2 more sources

Increased Midkine Expression in Hepatocellular Carcinoma

Archives of Pathology & Laboratory Medicine, 2000
AbstractContext.—Midkine (MK) is a novel heparin-binding growth factor whose gene was identified in embryonal carcinoma cells in early stages of retinoic acid–induced differentiation.Objective.—To examine the overexpression of MK in hepatocellular carcinoma (HCC).Methods.—Seventy-seven primary HCC specimens from patients aged 17 to 72 years (63 men and
M, Kato, T, Shinozawa, S, Kato, A, Awaya, T, Terada   +4 more
openaire   +2 more sources

Multiple cis‐regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis

The FEBS Journal, EarlyView.
midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen, Masanari Takamiya, Agnes Hendriks, Tanja Beil, Csilla Várnai, Nicolas Diotel, Sepand Rastegar   +6 more
wiley   +1 more source

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

Glia, Volume 74, Issue 5, May 2026.
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel   +4 more
wiley   +1 more source