Results 71 to 80 of about 6,907 (199)

Analysis of Urinary Midkine and Volatile Organic Compound (VOC) Levels Using a Breath Analyzer for Screening and Early Diagnosis of Lung Cancer

Jurnal Respirasi
Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Midkine, a heparin-binding growth factor, promotes proliferation, angiogenesis, and metastasis. Volatile organic compounds (VOCs) reflect cellular and molecular changes,
Saidah Mafisah, Ungky Agus Setyawan, Rezki Tantular, Deden Permana, Susanthy Djajalaksana, Arinto Yudi Ponco Wardoyo, Aditya Sri Listyoko   +6 more
doaj   +1 more source

Midkine binds specifically to sulfatide [PDF]

European Journal of Biochemistry, 2000
Midkine is a heparin‐binding polypeptide which is implicated in the control of development and repair of various tissues. Recognition of sulfate groups in glycosaminoglycans is important for its function. To elucidate further its mechanism of action, the interactions of midkine with sulfated glycolipids were studied.
N, Kurosawa, K, Kadomatsu, S, Ikematsu, S, Sakuma, T, Kimura, T, Muramatsu   +5 more
openaire   +2 more sources

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP‐1

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Yu Wang, Lu Fang, Chenyuan Zhai, Jili Cai, Xiangzhe Li, Lijuan Zong, Yao Geng, Chenchen Zhu, Cheng Sun, Manyu Dong, Yilun Qian, Yan Liu, Ying Huang, Zun Wang, Tong Wang, Wen‐Tao Liu, Qi Wu   +16 more
wiley   +1 more source

Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]

, 2017
BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D, Edgar, Kevin S, Grieve, David J, Kearney, Anna M, McDermott, Barbara J, McLaughlin, Declan, O'Neill, Karla M, Zhao, Youyou   +7 more
core   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta‐analysis

Molecular Genetics & Genomic Medicine, 2020
Background There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting.
Yu Zhang, Juan Tang, Xiao Zhou, Shao‐Liang Zhu, Le‐Qun Li   +4 more
doaj   +1 more source

Adenovirus as a Vector and Oncolytic Virus

Current Issues in Molecular Biology, 2023
Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses
Wataru Matsunaga, Akinobu Gotoh
doaj   +1 more source

The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]

, 2010
<b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Forrest, L.M., McMillan, D.C., Meek, C.L., Wallace, A.M.   +3 more
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis [PDF]

, 2014
Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration. Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines ...
Ashtari, Fereshteh., Dehghani, Leila., Gharagozloo, Marjan., Hasheminia, Seyed Javad., Jamshidian, Azam., Montazeri, Saeed., Shaygannejad, Vahid., Tahani, Soheil., Vesal, Sahar.   +8 more
core   +1 more source