Results 81 to 90 of about 6,907 (199)

Midkine and Melanoma Metastasis: A Malevolent Mix [PDF]

Developmental Cell, 2017
Using an in vivo reporter for lymphangiogenesis, a recent study in Nature from Olmeda et al. (2017) describes a new subset of melanomas that induce systemic pre-conditioning of distant organs for formation of tumor metastatic niches, and identifies the responsible factor as the pleiotropic cytokine midkine.
Karaman, Sinem, Alitalo, Kari
openaire   +3 more sources

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation [version 4; peer review: 2 approved]

F1000Research
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research would
Peter S. McPherson, Carl Laflamme, Aled M. Edwards, Kathleen Southern, Riham Ayoubi   +4 more
doaj   +1 more source

Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study

Romanian Journal of Internal Medicine, 2022
Background: The incidence of liver cancer is increased worldwide with 75%–85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with ...
Darmadi Darmadi, Ruslie Riska Habriel, Pakpahan Cennikon   +2 more
doaj   +1 more source

9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells [PDF]

, 2012
The isomer 9-cis of retinoic acid (9-cis-RA) exerts a beneficial effect on bovine in vitro development when added to in vitro maturation (IVM) culture. In the present work, 9-cis-RA 5 nM was found to be stimulatory as opposed to 500 nM (toxic).
Carneiro, Gustavo, Duque, Paloma, Díez, Carmen, Facal, Nieves, Goyache, Félix, Gómez, Enrique, Hidalgo, C.O. (Carlos), Lorenzo, P.L. (Pedro), Royo, L.J. (Luis), Álvarez, Isabel   +9 more
core  

Assessing Aβ‐independent effects of Module 42 on immune function in vitro

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION A deep multi‐omic analysis of post mortem human brains has identified a new co‐expression protein network – Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)‐associated proteins, including the amyloid precursor protein (APP) and apolipoprotein
Ishita Ajith, Souvika Bakshi, Emma Mead, Opher Gileadi, Vittorio L. Katis, Paul E. Brennan, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Katerina O. Gospodinova   +7 more
wiley   +1 more source

A single intracoronary injection of midkine reduces ischemia/reperfusion injury in swine hearts: a novel therapeutic approach for acute coronary syndrome

Frontiers in Physiology, 2011
Several growth factors are effective for salvaging myocardium and limiting infarct size in experimental studies with small animals. Their benefit in large animals and feasibility in clinical practice remains to be elucidated.
Hisaaki eIshiguro, Hisaaki eIshiguro, Mitsuru eHoriba, Mitsuru eHoriba, Hiroharu eTakenaka, Arihiro eSumida, Tobias Opthof, Yuko S Ishiguro, Kenji eKadomatsu, Kenji eKadomatsu, Toyoaki eMurohara, Itsuo eKodama   +11 more
doaj   +1 more source

Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

Frontiers in Neurology, 2020
Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and ...
Emily Ross-Munro, Faith Kwa, Faith Kwa, Jenny Kreiner, Madhavi Khore, Suzanne L. Miller, Mary Tolcos, Bobbi Fleiss, Bobbi Fleiss, David W. Walker   +9 more
doaj   +1 more source

Proteoglycans and neuronal migration in the cerebral cortex during development and disease [PDF]

, 2015
Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki Maeda
core   +2 more sources