Results 81 to 90 of about 6,987 (195)

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Spatial analysis of HPV‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

The Journal of Pathology, Volume 268, Issue 2, Page 200-214, February 2026.
Abstract Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV‐related cancers continue to rise. For the development of effective prevention strategies in high‐risk patients, we aimed to better understand the roles of inflammatory pathways and the tumour microenvironment as the main driver of ...
Gianna Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O'Brien, Michael Walsh, Andrew Causer, Janin Chandra, Quan Nguyen, Ian H Frazer   +9 more
wiley   +1 more source

Midkine and Melanoma Metastasis: A Malevolent Mix [PDF]

Developmental Cell, 2017
Using an in vivo reporter for lymphangiogenesis, a recent study in Nature from Olmeda et al. (2017) describes a new subset of melanomas that induce systemic pre-conditioning of distant organs for formation of tumor metastatic niches, and identifies the responsible factor as the pleiotropic cytokine midkine.
Karaman, Sinem, Alitalo, Kari
openaire   +3 more sources

A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation [version 4; peer review: 2 approved]

F1000Research
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research would
Peter S. McPherson, Carl Laflamme, Aled M. Edwards, Kathleen Southern, Riham Ayoubi   +4 more
doaj   +1 more source

9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells [PDF]

, 2012
The isomer 9-cis of retinoic acid (9-cis-RA) exerts a beneficial effect on bovine in vitro development when added to in vitro maturation (IVM) culture. In the present work, 9-cis-RA 5 nM was found to be stimulatory as opposed to 500 nM (toxic).
Carneiro, Gustavo, Duque, Paloma, Díez, Carmen, Facal, Nieves, Goyache, Félix, Gómez, Enrique, Hidalgo, C.O. (Carlos), Lorenzo, P.L. (Pedro), Royo, L.J. (Luis), Álvarez, Isabel   +9 more
core  

Characterising the Periodontal Granulation Tissue Using scRNAseq

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 308-320, February 2026.
ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu, Kathy Fung, Pawan Dhami, Paul Sharpe, Jan Krivanek, Luigi Nibali, Cheng Zhang, Vitor C. M. Neves   +7 more
wiley   +1 more source

A single intracoronary injection of midkine reduces ischemia/reperfusion injury in swine hearts: a novel therapeutic approach for acute coronary syndrome

Frontiers in Physiology, 2011
Several growth factors are effective for salvaging myocardium and limiting infarct size in experimental studies with small animals. Their benefit in large animals and feasibility in clinical practice remains to be elucidated.
Hisaaki eIshiguro, Hisaaki eIshiguro, Mitsuru eHoriba, Mitsuru eHoriba, Hiroharu eTakenaka, Arihiro eSumida, Tobias Opthof, Yuko S Ishiguro, Kenji eKadomatsu, Kenji eKadomatsu, Toyoaki eMurohara, Itsuo eKodama   +11 more
doaj   +1 more source

Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study

Romanian Journal of Internal Medicine, 2022
Background: The incidence of liver cancer is increased worldwide with 75%–85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with ...
Darmadi Darmadi, Ruslie Riska Habriel, Pakpahan Cennikon   +2 more
doaj   +1 more source

An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced [PDF]

, 2017
BackgroundGenetically modified adenoviruses (Ad) with preferential replications in tumor cells have been examined for a possible clinical applicability as an anti-cancer agent.
Hanazono Michiko, Hiroshima Kenzo, Morinaga Takao, Nguyễn Thảo Thi Thanh, Sekine Ikuo, Shimada Hideaki, Shingyoji Masato, Tada Yuji, Tagawa Masatoshi, Tatsumi Koichiro, Zhong Boya, 関根 郁夫   +11 more
core   +1 more source

Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

Frontiers in Neurology, 2020
Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and ...
Emily Ross-Munro, Faith Kwa, Faith Kwa, Jenny Kreiner, Madhavi Khore, Suzanne L. Miller, Mary Tolcos, Bobbi Fleiss, Bobbi Fleiss, David W. Walker   +9 more
doaj   +1 more source