Midkine (MDK) in cancer and drug resistance: from inflammation to therapy [PDF]
Discover OncologyMidkine (MDK) is a heparin-binding growth factor implicated in the pathogenesis of various diseases, including cancer, chronic inflammation, and multidrug resistance (MDR).
Berna Yıldırım +2 more
doaj +3 more sources
Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker [PDF]
CellsMidkine (MDK) is a multifunctional secreted protein that can act as a cytokine or growth factor regulating multiple signaling pathways and being implicated in fundamental cellular processes, such as survival, proliferation, and migration.
Christiana Christou +2 more
doaj +4 more sources
Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches [PDF]
European Journal of Breast HealthMidkine (MDK) is a protein that contributes to both physiological and pathological processes. Several studies provide insight into the different roles of MDK in development, tissue repair, neural plasticity, and health and disease processes.
Berna Yıldırım +2 more
doaj +5 more sources
Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. [PDF]
PLoS ONE, 2013 Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
Huifang Hao +17 more
doaj +4 more sources
Midkine (MDK) growth factor::a key player in cancer progression and a promising therapeutic target [PDF]
Oncogene, 2019 Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development ...
Constantinidou, Anastasia +2 more
core +4 more sources
Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment [PDF]
Scientific ReportsMidkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into
Mieszko Lachota +5 more
doaj +2 more sources
Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK). [PDF]
Mol Biol Cell, 2015 Midkine (MDK) expression is associated with the proliferation of many cancers, including glioma. However, the upstream signaling that leads to MDK accumulation remains elusive. This study investigates the molecular mechanism that induces MDK overexpression in human glioma.
Luo J +7 more
europepmc +3 more sources
Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury [PDF]
Advanced ScienceAcute kidney injury (AKI) is associated with a high prevalence of cognitive impairment, the underlying mechanisms remain elusive. This study explores the role of midkine (MDK), upregulated in renal injury, in mediating cognitive dysfunction following ...
Li Lu +10 more
doaj +2 more sources
Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer [PDF]
Cancer MedicinePurpose Small cell lung cancer (SCLC) is a highly aggressive disease associated with poor patient survival rates. The addition of an anti‐programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis.
Shotaro Ito +16 more
doaj +2 more sources
Midkine Expression as a Candidate Biomarker to Predict the Recurrence of Stage IA Lung Adenocarcinoma [PDF]
JTO Clinical and Research ReportsBackground: Early recurrence limits the long-term survival of postoperative patients with stage IA lung adenocarcinoma (LUAD). This study aims to risk-stratify postoperative stage IA LUAD by means of the expression of Midkine (MDK). Materials and Methods:
Xiao Yang, PhD +10 more
doaj +2 more sources