Results 11 to 20 of about 3,058 (153)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis [PDF]

Advanced Science
Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for enabling an ...
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
doaj   +3 more sources

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma [PDF]

Advanced Science
Lung squamous cell carcinoma (LUSC) remains a lethal malignancy with limited therapeutic advancements, underscoring the need to identify novel oncogenic drivers.
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
doaj   +3 more sources

LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study [PDF]

Annals of Medicine
Background Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is ...
Juan Wang, Chao Li, Guanghai Wu, Jing Xu
doaj   +2 more sources

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare the performance of MDK with that of anterior ...
Edgell Tracey A, Rice Gregory E, Autelitano Dominic J   +2 more
doaj   +5 more sources

Exploring drug resistance via intercellular crosstalk using spatial transcriptomics in high-grade serous ovarian carcinoma [PDF]

npj Precision Oncology
Poly(ADP-ribose) polymerase inhibitors (PARPis) have improved the prognosis of patients with high-grade serous ovarian carcinoma (HGSOC). However, PARPis are not effective for all HGSOC patients.
Hironori Suzuki, Kosuke Yoshida, Akira Yokoi, Kazuhiro Suzuki, Yuta Hirano, Masami Kitagawa, Eri Asano-Inami, Masato Yoshihara, Yukari Nagao, Satoshi Tamauchi, Nobuhisa Yoshikawa, Hiroaki Kajiyama, Yusuke Yamamoto   +12 more
doaj   +2 more sources

Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease [PDF]

Biomedicines
Alzheimer’s disease (AD) involves a constellation of molecular processes that extend well beyond amyloid-β (Aβ) accumulation. Recent anti-amyloid antibodies provide limited clinical benefits, highlighting the need for additional strategies due to their ...
Martina Monaco, Alessandra Pinto, Massimo Grilli   +2 more
doaj   +2 more sources

Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis [PDF]

Caspian Journal of Internal Medicine
Background: Hepatocellular carcinoma (HCC) posed significant health problems and deaths. There are various challenges in the management of HCC, including the late detection or diagnosis.
Masrul Lubis, Darmadi Darmadi, Sem Samuel Surja, Cennikon Pakpahan   +3 more
doaj   +2 more sources

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma [PDF]

Clinical and Translational Medicine
Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy.
Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu   +7 more
doaj   +2 more sources

Stress-Induced Activation of Prolactin-NR4A1-Midkine Axis Exacerbates Skin Inflammation. [PDF]

Adv Sci (Weinh)
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Li Z, Quan H, Liu W, Chen J, Chu M, Tang X, Xue K, Liu X, Ma J, Bai Y, Dong R, Li B, Hao J, Guo W, Li Q, Dang E, Gudjonsson JE, Wang G, Shao S.   +18 more
europepmc   +2 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources