Results 21 to 30 of about 3,058 (153)

Sleep apnoea increases biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk patients and those with established lung cancer [PDF]

ERJ Open Research
Background Intermittent hypoxaemia and obstructive sleep apnoea (OSA) have been linked to lung cancer through as yet unidentified pathophysiological mechanisms.
Carolina Cubillos-Zapata, Fernanda Troncoso-Acevedo, Elena Díaz-García, Enrique Alfaro, Carolina Gotera-Rivera, Teresa Pérez-Warnisher, Germán Peces-Barba, Luis M. Seijo, Francisco García-Río   +8 more
doaj   +3 more sources

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma

Archives of Medical Science, 2021
Introduction The prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels of genes selected from relevant literature and to utilize in silico methods to determine genes ...
Hakan Akgun, Selma Metintas, Guntulu Ak, Secil Demirkol Canlı, Murat Isbilen, Ali O. Gure, Muzaffer Metintas   +6 more
doaj   +1 more source

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Cell Death and Disease, 2022
Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain
Tian Xia, Di Chen, Xiaolong Liu, Huan Qi, Wen Wang, Huan Chen, Ting Ling, Wuxiyar Otkur, Chen-Song Zhang, Jongchan Kim, Sheng-Cai Lin, Hai-long Piao   +11 more
doaj   +1 more source

Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. [PDF]

PLoS ONE, 2016
Midkine (MDK) and pleiotrophin (PTN) are heparin-binding growth factors that, in rodents, are highly expressed in early life and decrease to undetectable levels by adulthood.
Youn Hee Jee, Yael Lebenthal, Piya Chaemsaithong, Gai Yan, Ivana Peran, Anton Wellstein, Roberto Romero, Jeffrey Baron   +7 more
doaj   +1 more source

Inhibition of Midkine Augments Osteoporotic Fracture Healing. [PDF]

PLoS ONE, 2016
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton.
Melanie Haffner-Luntzer, Julia Kemmler, Verena Heidler, Katja Prystaz, Thorsten Schinke, Michael Amling, Anna Kovtun, Anna E Rapp, Anita Ignatius, Astrid Liedert   +9 more
doaj   +1 more source

The role of midkine in health and disease

Frontiers in Immunology, 2023
Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair.
Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer   +2 more
doaj   +1 more source

The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. [PDF]

PLoS ONE, 2014
Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2.
Fredrik Hugosson, Camilla Sjögren, Anna Birve, Ludmilla Hedlund, Therese Eriksson, Ruth H Palmer   +5 more
doaj   +1 more source

Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area [PDF]

, 2015
Background: Identification of tumour antigens is crucial for the development of vaccination strategies against hepatocellular carcinoma (HCC). Most studies come from eastern-Asia, where hepatitis-B is the main cause of HCC.
A Ferrandez-Izquierdo, A Fujimoto, A Jemal, A Liu, AA Jungbluth, B Li, B Yan, BG Peng, C Brumm, C Landry, C Langner, C Liu, C Verhoef, CC Wang, CD Witjes, CH Chen, D Sprengers, DJ Brennan, DS Yee, DW Ho, E Schultz-Thater, E Yakaboski, F Monma, G Luo, GK Abou-Alfa, GR Yu, GY Chau, H Shirakawa, HA Vaughan, HB El-Serag, HB El-Serag, HM Lacy, HS Mohammad, I Mellman, J Filmus, J Frayne, J Kwekkeboom, J Liang, J N M IJzermans, JF Perz, JM Lang, JM Llovet, JR Peng, K Biermann, K Sideras, K Yorita, KJ Yong, KJ Yong, L Zheng, LQ Wu, M Deguchi, M J Bruno, M Kuang, M Tsuji, MA Cheever, MI Minervini, MO Riener, N Koide, NR dos Santos, O Hofmann, P Ganjei, P Kvistborg, P Li, P Zhao, PW Kantoff, PW Kantoff, Q Pan, QY Xia, R A de Man, R Kannangai, R Zhuang, S J Bots, S Nakamura, S Nakatsuka, S Sleijfer, SK Lau, SS Zeng, T Longerich, T Oikawa, T Sera, V Gerke, V Scharnhorst, W G Polak, W Zou, WC Lee, WJ Ma, WW Zhu, X Zhang, Y Cao, Y Sawada, Z Liu   +90 more
core   +10 more sources

Midkine’s Role in Cardiac Pathology

Journal of Cardiovascular Development and Disease, 2017
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated
Kathleen C. Woulfe, Carmen C. Sucharov
doaj   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source