Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation. [PDF]
, 2016 UNLABELLED: Vascular smooth muscle cells (SMCs) from distinct anatomic locations derive from different embryonic origins. Here we investigated the respective potential of different embryonic origin-specific SMCs derived from human embryonic stem cells ...
Bargehr, Johannes +7 more
core +2 more sources
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
core +2 more sources
Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma [PDF]
, 2013 Background: Proteomic discovery of cancer biomarkers in body fluids is challenging because of their low abundance in a complex background. Altered gene expression in tumours may not reflect protein levels in body fluids.
A Martin +54 more
core +3 more sources
Role of midkine in cancer drug resistance: Regulators of its expression and its molecular targeting [PDF]
, 2023 Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers ...
Cheung, Nathan +3 more
core +2 more sources
Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. [PDF]
PLoS ONE, 2014 The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator
Melanie Haffner-Luntzer +7 more
doaj +1 more source
The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo
Neoplasia: An International Journal for Oncology Research, 2008 Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers.
Edward Htun van der Horst +8 more
doaj +1 more source
Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. [PDF]
, 2015 In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. In women, menopause is associated with increased risk of memory disturbances, which can be attenuated by timely estrogen therapy.
Annie Rodolosse +7 more
core +1 more source
Biomarkers for Hepatocellular Carcinoma [PDF]
, 2017 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The HCC diagnosis is usually achieved by biomarkers, which can also help in prognosis prediction.
Jiang, Shuai +4 more
core +2 more sources
Midkine promotes glioblastoma progression via PI3K-Akt signaling
Cancer Cell International, 2021 Background Our previous bioinformatics-based study found that midkine (MDK) was associated with poor prognosis of glioblastoma (GBM). However, the mechanism of MDK in GBM remains elusive.
Beiquan Hu +8 more
doaj +1 more source
Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma
Cancer Cell International, 2023 Background Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers.
Tai-Jan Chiu +5 more
doaj +1 more source