Results 41 to 50 of about 3,058 (153)

Serum midkine levels for the diagnosis and assessment of response to interventional therapy in patients with hepatocellular carcinoma

Journal of Interventional Medicine, 2021
Objective: To explore the clinical significance of serum midkine (MDK) levels for the diagnosis of hepatocellular carcinoma (HCC) and evaluate the efficacy of interventional therapy.
Lin Zheng, Hailiang Li, Jinhua Huang, Jihoon Shin, Suxia Luo, Chenyang Guo, Yan Zhao, Fangkun Li   +7 more
doaj   +1 more source

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus [PDF]

, 2015
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
González Castillo, Celia, Guzmán-Brambila, Carolina, Ortuño Sahagún, Daniel, Pallàs i Llibería, Mercè, 1964-, Rojas-Mayorquín, Argelia E.   +4 more
core   +2 more sources

Midkine Gene (MDK), a Gene for Prenatal Differentiation and Neuroregulation, Maps to Band 11p11.2 by Fluorescence in Situ Hybridization

Genomics, 1993
Midkine (MDK) is a retinoic acid-responsive gene concerned with prenatal development and neurite growth. We mapped the gene to band p11.2 of chromosome 11 through fluorescence in situ hybridization analysis and using a 4.5-kb fragment of its human genomic DNA.
T, Kaname, A, Kuwano, I, Murano, K, Uehara, T, Muramatsu, T, Kajii   +5 more
openaire   +2 more sources

Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line

Biomedicines, 2022
Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy.
Qun Liu, Jingyu Tan, Zhenguo Zhao, Ruijun Li, Luyu Zheng, Xiangyu Chen, Lina Li, Xichen Dong, Tao Wen, Jian Liu   +9 more
doaj   +1 more source

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. [PDF]

, 2016
Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER).
Hrabovszky, E., Kallo, I., Liposits, Zsolt, Rodolosse, A., Sarvari, M., Solymosi, N.   +5 more
core   +1 more source

Limited effects of preterm birth and the first enteral nutrition on cerebellum morphology and gene expression in piglets [PDF]

, 2016
Preterm pigs show many signs of immaturity that are characteristic of preterm infants. In preterm infants, the cerebellum grows particularly rapid and hypoplasia and cellular lesions are associated with motor dysfunction and cognitive deficits.
Allais, Alvarez-Saavedra, Andersen, Andersen, Ben-Zvi, Blencowe, Brew, Caminita, Cao, Carter, Carter, Chiral, Choudhri, Colvin, Conrad, Dahmane, Dienel, Dobbing, Elmore, Flora, Ghoumari, Gundersen, Gundersen, Haldipur, Haldipur, Hansen, Hart, Hatten, Hou, Hurtado De Mendoza, Jiang, Johnson, Kadomatsu, Keunen, Kiessling, Kieviet, Kim, Kooij, Krigger, Krum, Kuypers, Limperopoulos, Liu, Luissint, Nico, Noguchi, Nosarti, Patra, Radlowski, Rakic, Sadowska, Sangild, Sangild, Sentilhes, Silwedel, Skiold, Skovgaard, Skovgaard, Solowska, Takacs, Vandesompele, Villanueva, Volpe, Volpe, Winter, Wyatt, Yuen   +66 more
core   +2 more sources

Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data

Frontiers in Genetics, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying molecular ...
Shichen Zhang, Lanlan Zhang, Lu Wang, Hongqiu Wang, Jiaxin Wu, Haoyang Cai, Chunheng Mo, Jian Yang   +7 more
doaj   +1 more source

Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]

, 2017
BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D, Edgar, Kevin S, Grieve, David J, Kearney, Anna M, McDermott, Barbara J, McLaughlin, Declan, O'Neill, Karla M, Zhao, Youyou   +7 more
core   +1 more source

Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics. [PDF]

, 2021
Long-range communication between tumor cells and the lymphatic vasculature defines competency for metastasis in different cancer types, particularly in melanoma.
Alonso-Curbelo, Direna, Calvo, Tonantzin G, Cañón, Estela, Cerezo-Wallis, Daniela, Ibarz, Nuria, Mucientes, Cynthia, Muñoz, Javier, Olmeda, David, Ortega Jimenez, Sagrario, Ortiz-Romero, Pablo, Rodriguez-Peralto, José L, Soengas, MS   +11 more
core   +1 more source

The expression and function of midkine in the vertebrate retina [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102704/1/bph12495 ...
Cameron DA, Dowling JE, Hsiao HY, Inatani M, Inatani M, Karthikeyan L, Masuda K, Unoki K, Wolff T   +8 more
core   +1 more source