Results 51 to 60 of about 3,058 (153)

Serum Midkine and Osteopontin Levels as Diagnostic Biomarkers of Hepatocellular Carcinoma

Electronic Physician, 2017
Introduction: Hepatocellular Carcinoma (HCC) is a primary tumor of the liver; it is one of the most common cancers worldwide. Osteopontin (OPN) is a phosphorylated glycoprotein which is implicated in enhancing invasive and metastatic progression of ...
Hossam Hodeib, Ola ELshora, Amal Selim, Nesreen Mohammed Sabry, Heba Mohamed EL-ashry   +4 more
doaj   +1 more source

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins

Frontiers in Oncology, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Luyu Zheng, Qun Liu, Ruijun Li, Shibin Chen, Jingyu Tan, Lina Li, Xichen Dong, Changzhi Huang, Tao Wen, Jian Liu, Jian Liu   +10 more
doaj   +1 more source

A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor [PDF]

, 2015
The PI3K–AKT pathway is expected to be a therapeutic target for non-small cell lung cancer (NSCLC) treatment. We previously reported that a novel PI3K inhibitor iMDK suppressed NSCLC cells in vitro and in vivo without harming normal cells and mice ...
Bao, Xiao-Hong, Fukazawa, Takuya, Grant, Shawn N., Haisa, Minoru, Hao, Huifang, Ishida, Naomasa, Kato, Katsuya, Maeda, Yutaka, Matsumoto, Kenichi, Morita, Ichiro, Naomoto, Yoshio, Okui, Tatsuo, Shigemitsu, Kaori, Shimo, Tsuyoshi, Takaoka, Munenori, Takigawa, Nagio, Whitsett, Jeffrey A., Yamatsuji, Tomoki, Yokota, Etsuko   +18 more
core   +1 more source

Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer [PDF]

, 2021
Rationale: Little is known about the roles of proteoglycans in esophageal cancer. This study aims to investigate the roles and mechanisms of serglycin (SRGN) proteoglycan in promoting metastasis of esophageal squamous cell carcinoma (ESCC).
Chan, KT, Cheung, ALM, Cui, D, Lau, AKY, Law, S, Lee, NPY, Li, B, Shum, DKY, Tsao, SW, Xu, WW, Yan, DD, Zhang, J, Zhu, Y   +12 more
core   +1 more source

Autocrine and paracrine effects of MDK promote lymph node metastasis of cervical squamous cell carcinoma

iScience
Summary: Lymph node metastasis (LNM) is the main metastatic pathway of cervical cancer, which is closely related to 5-year survival rate of cervical squamous cell carcinoma (CSCC), yet the underlying mechanism remains unconfirmed.
He Fei, Tong Chen, Hua Jiang
doaj   +1 more source

Midkine Prevents Calcification of Aortic Valve Interstitial Cells via Intercellular Crosstalk

Frontiers in Cell and Developmental Biology, 2021
Calcified aortic valve disease (CAVD), the most common valvular heart disease, lacks pharmaceutical treatment options because its pathogenesis remains unclear.
Qian Zhou, Qian Zhou, Qian Zhou, Hong Cao, Xiaoyi Hang, Xiaoyi Hang, Xiaoyi Hang, Huamin Liang, Huamin Liang, Huamin Liang, Miaomiao Zhu, Miaomiao Zhu, Miaomiao Zhu, Yixian Fan, Yixian Fan, Yixian Fan, Jiawei Shi, Nianguo Dong, Ximiao He, Ximiao He, Ximiao He   +20 more
doaj   +1 more source

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma.

PLoS ONE, 2016
UnlabelledRobust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with
Roslyn Vongsuvanh, David van der Poorten, Tristan Iseli, Simone I Strasser, Geoffrey W McCaughan, Jacob George   +5 more
doaj   +1 more source

Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]

, 2016
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik, Kalló, Imre, Liposits, Zsolt, Solymosi, Norbert, Sárvári, Miklós   +4 more
core   +1 more source

Correction: Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancer

PLOS ONE
[This corrects the article DOI: 10.1371/journal.pone.0071093.].
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto   +17 more
openaire   +4 more sources

USP12 promotes breast cancer angiogenesis by maintaining midkine stability

Cell Death and Disease, 2021
Deubiquitinases (DUBs) have important biological functions, but their roles in breast cancer metastasis are not completely clear. In this study, through screening a series of DUBs related to breast cancer distant metastasis-free survival (DMFS) in the ...
Bin Sheng, Zichao Wei, Xiaowei Wu, Yi Li, Zhihua Liu   +4 more
doaj   +1 more source