Results 61 to 70 of about 3,058 (153)

Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages [PDF]

, 2018
Background: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic
Blandino, Giovanni, Donzelli, Sara, Fazi, Francesco, Fontemaggi, Giulia, Gallo, Enzo, Iosue, Ilaria, Masciarelli, Silvia, Melucci, Elisa, Milano, Elisa, Mottolese, Marcella, Pruszko, Magdalena, Sacconi, Andrea, Terrenato, Irene, Zylicz, Alicja, Zylicz, Maciej   +14 more
core   +3 more sources

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport [PDF]

, 2019
The Glutamate Receptor Ionotropic NMDA-Associated Protein 1 (GRINA) belongs to the Lifeguard family and is involved in calcium homeostasis, which governs key processes, such as cell survival or the release of neurotransmitters. GRINA is mainly associated
García Quintanilla, Alberto, García Quintanilla, Meritxell de Jesús, Jiménez González, Victor, Ogalla García, María Elena   +3 more
core   +1 more source

Spatial analysis of HPV‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

The Journal of Pathology, Volume 268, Issue 2, Page 200-214, February 2026.
Abstract Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV‐related cancers continue to rise. For the development of effective prevention strategies in high‐risk patients, we aimed to better understand the roles of inflammatory pathways and the tumour microenvironment as the main driver of ...
Gianna Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O'Brien, Michael Walsh, Andrew Causer, Janin Chandra, Quan Nguyen, Ian H Frazer   +9 more
wiley   +1 more source

The multifaceted role of midkine in gastrointestinal cancer: From biomarker to treatment

Cancer Treatment and Research Communications
Gastrointestinal cancer represents a substantial global health challenge, contributing to over one-third of cancer-related mortality worldwide. The progression of these malignancies involves complex molecular and physiological mechanisms, with Midkine ...
Zahra Rasoulizadeh, Amir Mohammad Nezhad Salari, Arezoo Gowhari Shabgah, Ghasem Sargazi, Roghayyeh Vakili-Ghartavol, Najmeh Mohammadpour, Reza Beheshti Monfared, Jamshid Gholizadeh   +7 more
doaj   +1 more source

The Value of Serum Midkine Level in Diagnosis of Hepatocellular Carcinoma

International Journal of Hepatology, 2015
Background and Aim. Identification of sensitive biomarkers to improve early diagnosis of HCC is needed. We aimed to evaluate serum midkine (MDK) as a biomarker for HCC diagnosis. Patients and Methods.
Karim Y. A. Shaheen, Abeer I. Abdel-Mageed, Eslam Safwat, Ashraf M. AlBreedy   +3 more
doaj   +1 more source

Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours [PDF]

, 2014
Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT), are rare complications following organ/stem cell transplantation. Despite the mainly benign behaviour of PTSMT, alternative therapies are needed for those patients with ...
Britta Ludewig, Danny Jonigk, Eileen Schormann, Hans Kreipe, Kais Hussein, Lavinia Maegel, Nicole Izykowski   +6 more
core   +1 more source

Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition

Communications Biology
Numerous myofibroblasts are arisen from endothelial cells (ECs) through endothelial to mesenchymal transition (EndMT) triggered by TGF-β. However, the mechanism of ECs transforms to a different subtype, or whether there exists an intermediate state of ...
Cuidi Xu, Juntao Chen, Lifei Liang, Siyue Chen, Xinhao Niu, Ruirui Sang, Cheng Yang, Ruiming Rong   +7 more
doaj   +1 more source

The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer

Nature Communications
Younger premenopausal women are more prone to developing ovarian metastases (OM) of gastric cancer (GC) than metastases of other organs; however, the molecular mechanisms remain unclear. Here we perform single-cell RNA sequencing on 45 tumor samples from
Simeng Hu, Can Hu, Jingli Xu, Pengfei Yu, Li Yuan, Ziyu Li, Haohong Liang, Yanqiang Zhang, Jiahui Chen, Qing Wei, Shengjie Zhang, Litao Yang, Dan Su, Yian Du, Zhiyuan Xu, Fan Bai, Xiangdong Cheng   +16 more
doaj   +1 more source

Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma [PDF]

, 2023
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease characterized by its metastatic potential and chemoresistance. These traits are partially attributable to the highly tumorigenic pancreatic cancer stem cells (PaCSCs ...
Courtois, Sarah, Curiel-García, Álvaro, Espiau-Romera, Pilar, Heeschen, Christopher, Olive, Kenneth P., Parejo-Alonso, Beatriz, Royo-García, Alba, Sancho, Patricia, Villaoslada, Isabel, Zagorac, Sladjana   +9 more
core   +1 more source