Results 71 to 80 of about 3,058 (153)
Journal of Neuroinflammation, 2020 Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
Seiya Takada +8 more
doaj +1 more source
Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy [PDF]
, 2023 Increases in non-communicable and auto-immune diseases, with a shared etiology of defective autophagy and chronic inflammation, have motivated research both on natural products in drug discovery fields and on the interrelationship between autophagy and ...
Abduazizova, Veronika +6 more
core +1 more source
Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.We provide the first single‐cell atlas of the human decidua in advanced maternal age (AMA). A novel PRR15‐TGF‐β axis is identified, where PRR15 loss drives stromal fibrosis and decidualisation failure. This study reveals that AMA‐associated uterine fibrosis begins in the first trimester, shifting focus to maternal factors.
Hongliang Xie +13 more
wiley +1 more source
Single-cell RNA-seq identified novel genes involved in primordial follicle formation
Frontiers in Endocrinology, 2023 IntroductionThe number of primordial follicles (PFs) in mammals determines the ovarian reserve, and impairment of primordial follicle formation (PFF) will cause premature ovarian insufficiency (POI).MethodsBy analyzing public single-cell RNA sequencing ...
Hang-Jing Tan +7 more
doaj +1 more source
Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia [PDF]
, 2014 Background: The major function of the ovary is to produce oocytes for fertilisation. Oocytes mature in follicles surrounded by nurturing granulosa cells and all are enclosed by a basal lamina.
Harland, M. +5 more
core +1 more source
TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer
iMetaOmics, Volume 2, Issue 4, December 2025.This study defined 10,921 tissue‐biased genes across 54 normal tissues and 41 cancer types. Tumor‐associated tissue‐biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as ...
Zhuobin Lin +7 more
wiley +1 more source
PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study. [PDF]
, 2023 Corrigendum to "PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study" [Biomed. Pharmacother. 159 (2023) 114220].
Berenguer, Juan +11 more
core +2 more sources
MedComm – Oncology, Volume 4, Issue 4, December 2025.Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan +7 more
wiley +1 more source
The Growth Factor/cytokine Midkine May Participate in Cytokine Storm and Contribute to the Pathogenesis of Severe Acute Respiratory Syndrome Coronavirus 2-infected Patient [PDF]
, 2021 Background The current coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged in Wuhan, China, and has rapidly become a global challenge, creating major challenges to health systems
Aynacıoğlu, Ahmet Şükrü +1 more
core +1 more source
Clinical and Translational Science, Volume 18, Issue 12, December 2025.ABSTRACT We used miRNA sequencing to identify candidate plasma pharmacodynamic (PD) biomarkers of interferon beta‐1a (IFNβ‐1a) biologics and explored miRNA‐mRNA targeted protein relationships and networks to support identified miRNA candidates. Plasma samples from 36 healthy subjects from a placebo‐controlled randomized single‐dose clinical study with ...
Mai Mehanna +11 more
wiley +1 more source