Results 81 to 90 of about 3,058 (153)

Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression

Genes and Diseases
Growth factors are bioactive molecules that play crucial roles in regulating growth, development, and disease processes, both locally and systemically.
Xieyidai Ruze, Yutong Hu, Xiongyi Wang, Houfu Lai, Ruizhi Zhang, Sheng Pan, Jiajun Zhang, Yike Wang, Simin Yun, Ying Xu, Junjie Li, Youjia Xu   +11 more
doaj   +1 more source

Intercellular crosstalk in adult dental pulp is mediated by heparin-binding growth factors Pleiotrophin and Midkine

BMC Genomics, 2023
Background In-depth knowledge of the cellular and molecular composition of dental pulp (DP) and the crosstalk between DP cells that drive tissue homeostasis are not well understood.
Natnicha Jiravejchakul, Gabriela L. Abe, Martin Loza, Soyoung Park, Ponpan Matangkasombut, Jun-Ichi Sasaki, Satoshi Imazato, Diego Diez, Daron M. Standley   +8 more
doaj   +1 more source

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter, Bondong, Sandra, Gast, Daniela, Gutwein, Paul, Kiefel, Helena, Riedle, Svenja, Wolterink, Silke   +6 more
core  

Frontiers in Pigment Cell and Melanoma Research

, 2018
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca, Bosenberg, Marcus W., Box, Neil F., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Filipp, Fabian V., Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Poole, Caroline Le, Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S.   +26 more
core   +1 more source

Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System [PDF]

, 2011
Midkine (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and other activities of target cells. After describing the general properties of MK, this review focuses on MK and MK inhibitors as therapeutics for diseases in the ...
Muramatsu, Takashi
core   +2 more sources

Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival [PDF]

, 2008
BackgroundMidkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis.
A Jemal, DR Haudenschild, E Jablonska, E Nakamura, F Kaplan, G Kulik, H Briscoe, H Muramatsu, J Lin, J Tsutsui, J Zhou, JJ Diez, Jonathan Melamed, K Kadomatsu, K Kadomatsu, K Kadomatsu, K Maruyama, K Owada, K Owada, K Uehara, KSR Sastry, L Trojan, Laurel A Beckett, M Horiba, M Muramaki, M Qi, M Ricote, M Tomomura, N Konishi, NJ Nesslinger, P Zou, PD Maroni, PR Reynolds, R Choudhuri, Regina Gandour-Edwards, S Luschen, T Muramatsu, T Yuki, V Michalaki, Xiangtian Kong, XP Pang, Y Takei, Ying Dong, YZ Lin, Z You, Z You, Z You, Zongbing You   +47 more
core   +2 more sources

Single‐Cell Transcriptomic Analysis Identifies a Novel OLR1+ SLC7A7+ Liver‐Enriched Metastatic Subset With Immunometabolic Rewiring in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally lethal malignancy, with high percents of patients presenting with liver metastases (LM). However, the mechanisms driving liver metastases remain critical bottlenecks requiring urgent exploration.
Xuan Yang, Xinyuan Chen, Zixin Wang, Yanfang Liu, Huiting Hu, Qingru Wu, Hailing Zhang, Yu Xiong, Xin Li, Xiaotao Cheng, Xiaoyu Ruan, Yan Gu   +11 more
wiley   +1 more source

Combination of imatinib mesylate with lithium chloride and medroxyprogesterone acetate is highly active in Ishikawa endometrial carcinoma in vitro [PDF]

, 2011
Objective: The aim of the study was to investigate whether lithium chloride and medroxyprogesterone acetate can potentiate the cytotoxicity of imatinib mesylate in human endometrial cancer in vitro and the effect of midkine in these ...
Abal, Ayhan Bilir, Bilir, Bilir, Cade, Cho, Di Cristofano, Erguven, Ezgi Ermis, Ha, Jemal, Lax, Madeddu, Miller, Mine Erguven, Mine Sencan, Mitsuhashi, Muramatsu, Nishio, Nuray Yazihan, Orrenius, Rawnaq, Salvatierra, Ustach, Vidal, Waller, Wang, Yang, Zhang, Zhu   +29 more
core   +2 more sources

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, Volume 25, Issue 21-22, Page 214-229, November 2025.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma

BMC Cancer, 2023
Background Early diagnosis of lung adenocarcinoma (LUAD), one of the most common types of lung cancer, is very important to improve the prognosis of patients. The current methods can’t meet the requirements of early diagnosis. There is a pressing need to
Junfeng Li, Jianjie Li, Huifeng Hao, Fangliang Lu, Jia Wang, Menglei Ma, Bo Jia, Minglei Zhuo, Jingjing Wang, Yujia Chi, Xiaoyu Zhai, Yuyan Wang, Meina Wu, Tongtong An, Jun Zhao, Fan Yang, Ziping Wang   +16 more
doaj   +1 more source