Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease
Pharmaceuticals, 2021 Diabetes mellitus is a global health issue and main cause of chronic kidney disease. Both diseases are also linked through high cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) is present in up to 40% of diabetic patients; therefore,
Nina Vodošek Hojs +5 more
doaj +3 more sources
Antiapoptotic effects of velvet antler polypeptides on damaged neurons through the hypothalamic-pituitary-adrenal axis [PDF]
Journal of Integrative Neuroscience, 2020 We investigated the effects of velvet antler polypeptide on cognitive impairment and the underlying mechanisms. Hydrogen peroxide-induced cell injury was used to establish an in vitro model of SH-SY5Y cells.
Qing Yang, Jia-Nan Lin, Xin Sui, Hui Li, Mo Kan, Ji-Feng Wang, Jing Li, Zhuang Zhang, Xiao-Ran Liu, Si-Tong Ming, Xiao-Bo Qu, Na Li
doaj +1 more source
Comparison of different strategies to measure medication adherence via claims data in patients with chronic heart failure [PDF]
, 2019 Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of ...
Griese‐Mammen, Nina +6 more
core +1 more source
Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: A systematic review and meta-analysis [PDF]
, 2016 Background: Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients.
Boesby, L. (Lene) +16 more
core +1 more source
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
PLoS ONE, 2014 The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson +2 more
doaj +1 more source
PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY
Рациональная фармакотерапия в кардиологии, 2017 The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj +1 more source
Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably! [PDF]
, 2017 No abstract ...
Aspirin Myocardial Infarction Study Research Group +23 more
core +1 more source
Frontiers in Physiology, 2022 Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez +10 more
doaj +1 more source
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]
Journal of Integrative Neuroscience, 2020 Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
doaj +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources