The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. [PDF]
PLoS Genetics, 2009 In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood.
Cyril Ribeyre +7 more
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Fragile sites, chromosomal lesions, tandem repeats, and disease
Frontiers in Genetics, 2022 Expanded tandem repeat DNAs are associated with various unusual chromosomal lesions, despiralizations, multi-branched inter-chromosomal associations, and fragile sites.
Mila Mirceta +7 more
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Repeat instability at human minisatellites arising from meiotic recombination [PDF]
The EMBO Journal, 1998 Little is known about the role of meiotic recombination processes such as unequal crossover in driving instability at tandem repeat DNA. Methods have therefore been developed to detect meiotic crossovers within two different GC-rich minisatellite repeat arrays in humans, both in families and in sperm DNA.
Jeffreys, AJ, Neil, DL, Neumann, R
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DNA secondary structure forming at minisatellite repeat unit sequences [PDF]
Nucleic Acids Symposium Series, 2006 The lengths of simple repeat sequences are generally unstable or polymorphic; that is, they are highly variable with respect to the numbers of tandem repeats. To determine the structural features that cause such variability, we examined a minisatellite DNA isolated from the yellow fin sea bream Acanthopagrus latus.
Takeshi, Haku +5 more
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Sequence-based estimation of minisatellite and microsatellite repeat variability [PDF]
Genome Research, 2007 Variable tandem repeats are frequently used for genetic mapping, genotyping, and forensics studies. Moreover, variation in some repeats underlies rapidly evolving traits or certain diseases. However, mutation rates vary greatly from repeat to repeat, and as a consequence, not all tandem repeats are suitable genetic markers or interesting unstable ...
Legendre, Matthieu +3 more
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Molecular mining of alleles in water buffalo Bubalus bubalis and characterization of the TSPY1 and COL6A1 genes. [PDF]
PLoS ONE, 2011 BACKGROUND: Minisatellites are an integral part of eukaryotic genomes and show variation in the complexity of their organization. Besides their presence in non-coding regions, a small fraction of them are part of the transcriptome, possibly participating
Sudeep Kumar +3 more
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Comparative Sequence Analysis of Human Minisatellites Showing Meiotic Repeat Instability [PDF]
Genome Research, 1999 The highly variable human minisatellites MS32 (D1S8), MS31A (D7S21), and CEB1 (D2S90) all show recombination-based repeat instability restricted to the germline. Mutation usually results in polar interallelic conversion or occasionally in crossovers, which, at MS32 at least, extend into DNA flanking the repeat array, defining a localized recombination ...
Murray, John +6 more
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Biologia Plantarum, 2016 Moth orchids (Phalaenopsis) are among the top-traded blooming potted plants in the world. To explore mitochondrial DNA (mtDNA) markers for species identification, we located simple sequence repeats in the mtDNA of Phalaenopsis aphrodite subsp.
B. -Y. Lin +9 more
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Attempts to detect retrotransposition and de novo deletion of Alus and other dispersed repeats at specific loci in the human genome [PDF]
, 2001 Dispersed repeat elements contribute to genome instability by de novo insertion and unequal recombination between repeats. To study the dynamics of these processes, we have developed single DNA molecule approaches to detect de novo insertions at a single
AJ Jeffreys +14 more
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Rare exonic minisatellite alleles in MUC2 influence susceptibility to gastric carcinoma. [PDF]
PLoS ONE, 2007 BACKGROUND: Mucins are the major components of mucus and their genes share a common, centrally-located region of sequence that encodes tandem repeats. Mucins are well known genes with respect to their specific expression levels; however, their genomic ...
Yun Hee Jeong +10 more
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