Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension [PDF]
EMBO Molecular Medicine, 2015 Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Kevin White +33 more
doaj +2 more sources
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
core +8 more sources
ROD1 is a seedless target gene of hypoxia-induced miR-210. [PDF]
PLoS ONE, 2012 Most metazoan microRNA (miRNA) target sites have perfect pairing to the "seed" sequence, a highly conserved region centering on miRNA nucleotides 2-7.
Pasquale Fasanaro +5 more
doaj +1 more source
Clinical and Translational Medicine, 2022 Background Colorectal cancer (CRC) has a high mortality rate, and therapeutic approaches to treat these cancers are varied and depend on the metabolic state of the tumour.
Steven Eliason +9 more
doaj +1 more source
Changes and Response Predictive Values of Serum miR-210 and miR-181a in Stable Chronic Obstructive Pulmonary Disease Patients Treated with Glucocorticoid Therapy [PDF]
Zhongguo quanke yixue, 2022 Background There are rare studies assessing the efficacy of inhaled glucocorticoids (ICS) , the common therapy for chronic obstructive pulmonary disease (COPD) .
Ke QIN, Tonglin LI, Shuai GONG, Meifang JIANG
doaj +1 more source
Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. [PDF]
PLoS ONE, 2014 MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear.
Ailin Qu +13 more
doaj +1 more source
Biomedicines, 2021 Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress.
Gurdeep Marwarha +4 more
doaj +1 more source
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation [PDF]
, 2021 Unbalanced immune responses to pathogens can be life-threatening although the underlying regulatory mechanisms remain unknown. Here, we show a hypoxia-inducible factor 1α-dependent microRNA (miR)-210 up-regulation in monocytes and macrophages upon ...
Cappellesso F. +27 more
core +8 more sources
MiR-210 regulates lung adenocarcinoma by targeting HIF-1α
Heliyon, 2023 Object: This study sought to elucidate the role of microRNA-210 (miR-210) in the occurrence and development of lung adenocarcinoma (LUAD). Methods: The levels of lncRNA miR-210HG and miR-210 in LUAD tissues and corresponding normal tissues were analyzed ...
Guolei Cao +6 more
doaj +1 more source
Thoracic Cancer, 2021 Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR‐210 expression has been identified in a variety of tumors.
Jing Meng +5 more
doaj +1 more source