Results 61 to 70 of about 367,365 (231)

Characterization of microRNA Levels in Synovial Fluid from Knee Osteoarthritis and Anterior Cruciate Ligament Tears

Biomedicines, 2022
This study investigated modifications of microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and rupture of the anterior cruciate ligament (ACL).
Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolò Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J. Omeljaniuk, Marco Bigoni, Antonio Torsello   +15 more
doaj   +1 more source

Xenes for Sustainable Energy: A Roadmap From First‐Principles Design to Practical Deployment

Advanced Materials Interfaces, EarlyView.
Emerging 2D Xenes are advancing from theoretical predictions toward practical energy‐storage and conversion technologies through the integration of first‐principles modelling, experimental synthesis, electrochemical validation, and AI‐assisted materials design, enabling accelerated discovery of high‐performance and sustainable electrochemical systems ...
Onur Karaman, Ceren Karaman
wiley   +1 more source

miR-144-3p and miR-486a-3p promote hepatocyte proliferation by directly targeting Txnip.

, 2023
(A) Txnip 3’-UTR target sequences of miR-144-3p and miR-486a-3p predicted using miRNA target prediction tools. Representative immunoblots and quantification of TXNIP in (B) primary cultured hepatocytes transfected with NC, miR-144-3p, or miR-486a-3p ...
Rei Okazaki (15411769), Masato Horino (14249459), Jun Aoki (2258638), Masanori Murakami (2530054), Kazutaka Tsujimoto (5086124), Tetsuya Yamada (219211), Chikara Komiya (3178998), Kenji Ikeda (500680), Yoshihiro Niitsu (14249456), Kazunari Hara (14249453), Akira Takeuchi (2421142)   +10 more
core   +1 more source

Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway

Molecular Medicine, 2020
Background The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored.
Fan Ye, Shiming Tian, Huimin Hu, Zhengwen Yu   +3 more
doaj   +1 more source

Expression profile of plasma microRNAs and target genes in patients with complicated pregnancy

Акушерство, гинекология и репродукция, 2023
Aim: comparative analysis of the expression profile of plasma microRNAs and target genes in patients with complicated pregnancy.Materials and Methods. A prospective observational comparative study in parallel groups was carried out. The study included 73
D. G. Pashkovsky, E. V. Solovieva, Ts. R. Rabadanova, P. T. Gorbunova, A. B. Dubovaya, E. R. Muslimova, E. E. Khoroz, Z. S. Karabash, L. E. Sorokina   +8 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel. [PDF]

Sci Rep, 2019
AbstractMicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospective cohort of breast cancer patients with a median follow-up of 76 months (n = 283).
Pasculli B, Barbano R, Rendina M, Fontana A, Copetti M, Mazza T, Valori VM, Morritti M, Maiello E, Graziano P, Murgo R, Fazio VM, Esteller M, Parrella P.   +13 more
europepmc   +6 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates P13K-p70S6K signalling

, 2022
Progressive neuronal injury following ischaemic stroke is associated with glutamate-induced depolarization, energetic stress and activation of AMP-activated protein kinase (AMPK).
Heiko Duessmann (7897355), Bryan Hennessy (7898999), Elisabeth Jirström (7898246), Niamh Connolly (7897562), Uta Mamrak (10653048), Stefan Haunsberger (7896197), Anna Tomašcová (10653045), Shona Pfeiffer (7896167), Alexa Resler (7954049), Nikolaus Plesnila (11287281), Jochen Prehn (7895672), Petronela Weisová (702732), Beatrice D'Orsi (7953470), Mattia Cremona (7895915), Gang Chen (7897352)   +14 more
core   +1 more source