Results 11 to 20 of about 482,752 (300)

miR-210 overexpression increases pressure overload-induced cardiac fibrosis [PDF]

Non-coding RNA Research
Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in ...
G. Zaccagnini, D. Baci, S. Tastsoglou, I. Cozza, A. Madè, C. Voellenkle, M. Nicoletti, C. Ruatti, M. Longo, L. Perani, C. Gaetano, A. Esposito, F. Martelli   +12 more
doaj   +4 more sources

Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210. [PDF]

Am J Respir Crit Care Med, 2023
RATIONALE Obstructive sleep apnea (OSA)-induced endothelial cell (EC) dysfunction contributes to OSA-related cardiovascular sequelae. The mechanistic basis of endothelial impairment by OSA is unclear. OBJECTIVES The goals of this study were to identify
Shang F, Wang SC, Gongol B, Han SY, Cho Y, Schiavon CR, Chen L, Xing Y, Zhao Y, Ning M, Guo X, He F, Lei Y, Wang L, Manor U, Marin T, Chou KT, He M, Huang PH, Shyy JY, Malhotra A.   +20 more
europepmc   +6 more sources

Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis. [PDF]

J Transl Med
Bone marrow mesenchymal stem cells (BMSCs) are a crucial component of the tumor microenvironment (TME), with hypoxic conditions promoting their migration to tumors. Exosomes play a vital role in cell-to-cell communication within the TME. Hypoxic TME have
Wang M, Zheng Y, Hao Q, Mao G, Dai Z, Zhai Z, Lin S, Liang B, Kang H, Ma X.   +9 more
europepmc   +2 more sources

miR-210: fine-tuning the hypoxic response [PDF]

, 2014
Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members ...
A Allegra, A Giannakakis, A Hüttenhofer, A Krek, A Shinohara, A Ventura, A Zhao, AC Koong, AE Pasquinelli, AM Cheng, AS Ho, B Malzkorn, B Wightman, BE Baysal, BJ Reinhart, BL Pineles, BP Lewis, BP Lewis, C Camps, C Devlin, C Nakada, C-C Chio, CH Lawrie, D Baek, D Betel, D Gou, D Hanahan, D Juan, DA Enquobahrie, DA Landau, DD Taylor, DP Bartel, DP Bartel, DS Schwarz, E Balsa, E Bostjancic, E Fabbri, E Fabbri, E Favaro, E Gottlieb, E Miko, E Rooij van, EJ Jung, F Mochel, F Rothe, F Wu, FE Benson, FV Karginov, G Leone, G Meroni, G Wan, GA Calin, GL Semenza, GL Semenza, GL Semenza, GL Semenza, GL Wang, GL Wang, GL Wang, H Antonicka, H Guo, H Iguchi, H Valadi, H Zhang, H-Y Chen, HE Gee, HW Kim, HW Kim, HW King, I Satzger, J Brugarolas, J He, J Lu, J Sarkar, J Stenvang, J Tabernero, J Wang, JA Foekens, JA Lees, JA Weber, JC Presti Jr, JC Venter, JD Gordan, JM Brown, JR Gnarra, JW Kim, K Jeyaseelan, K Pulkkinen, K Ruan, KP Porkka, L Cicchillitti, L Hong, L Qin, L Salmena, LP Lim, M Ivan, M Kertesz, M Liu, M Maragkakis, M Raponi, M Redova, M Selbach, MA Alaiti, MA Cortez, MA Valencia-Sanchez, ME Crosby, MP Murphy, MP Puissegur, MV Iorio, MV Iorio, MZ Michael, N Bushati, N Yanaihara, NC Denko, NC Denko, NL Simone, NMA White, O Bunoust, P Fasanaro, P Fasanaro, P Fasanaro, P Jaakkola, P Vaupel, PJ Hurlin, PS Mitchell, R Bindra, R Faraonio, R Gambari, R Garzon, R Kulshreshtha, R Kulshreshtha, RA Gatenby, RB Donker, RC Lee, RD Guzy, RE Lanford, RF Place, RK Mutharasan, S Biswas, S Djebali, S Djuranovic, S Djuranovic, S Gilad, S Greco, S Griffiths-Jones, S Hammer, S Hu, S Krick, S Kuijper, S Tsuchiya, S Vasudevan, S Wang, SA Ciafre, SY Chan, T Greither, T Greither, T Kawamata, T Li, T Thum, T Toyama, TJ Kelly, W Yang, W Zundel, WH Tong, WR Wilson, X Chen, X Huang, X Huang, X Zhang, XM Zhu, Y Lee, Y Lee, Y Liu, Y Liu, Y Mizuno, Y Murakami, Y Nakamura, Y Nie, YL Lou, Z Chen, Z Zhang   +180 more
core   +4 more sources

Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway. [PDF]

J Nanobiotechnology, 2023
Background Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition poses significant medical, economic, and social challenges.
Gao P, Yi J, Chen W, Gu J, Miao S, Wang X, Huang Y, Jiang T, Li Q, Zhou W, Zhao S, Wu M, Yin G, Chen J.   +13 more
europepmc   +2 more sources

miR-210: More than a silent player in hypoxi [PDF]

IUBMB Life, 2011
Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells.
Devlin, Cecilia, Greco, Simona, Ivan, Mircea, Martelli, Fabio   +3 more
core   +4 more sources

Hypoxia-preconditioned WJ-MSC spheroid-derived exosomes delivering miR-210 for renal cell restoration in hypoxia-reoxygenation injury. [PDF]

Stem Cell Res Ther
Recent advancements in mesenchymal stem cell (MSC) technology have paved the way for innovative treatment options for various diseases. These stem cells play a crucial role in tissue regeneration and repair, releasing local anti-inflammatory and healing ...
Toghiani R, Azimian Zavareh V, Najafi H, Mirian M, Azarpira N, Abolmaali SS, Varshosaz J, Tamaddon AM.   +7 more
europepmc   +2 more sources

Extracellular vesicle expansion of PMIS‐miR‐210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism

Clinical and Translational Medicine, 2022
Background Colorectal cancer (CRC) has a high mortality rate, and therapeutic approaches to treat these cancers are varied and depend on the metabolic state of the tumour.
Steven Eliason, Liu Hong, Yan Sweat, Camille Chalkley, Huojun Cao, Qi Liu, Hank Qi, Hongwei Xu, Fenghuang Zhan, Brad A. Amendt   +9 more
doaj   +2 more sources

miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells [PDF]

Frontiers in Genetics
IntroductionHypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis.
Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng   +8 more
doaj   +2 more sources

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia

Cell Death and Disease, 2021
Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that miR ...
Zaccagnini Germana, Greco Simona, Longo Marialucia, Maimone Biagina, Voellenkle Christine, Fuschi Paola, Carrara Matteo, Creo Pasquale, Maselli Davide, Tirone Mario, Mazzone Massimiliano, Gaetano Carlo, Spinetti Gaia, Martelli Fabio   +13 more
doaj   +2 more sources