ROD1 is a seedless target gene of hypoxia-induced miR-210. [PDF]
PLoS ONE, 2012 Most metazoan microRNA (miRNA) target sites have perfect pairing to the "seed" sequence, a highly conserved region centering on miRNA nucleotides 2-7.
Pasquale Fasanaro +5 more
doaj +4 more sources
Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension [PDF]
EMBO Molecular Medicine, 2015 Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Kevin White +33 more
doaj +2 more sources
Study on the mechanism and clinical value of miR-210-3p and miR-582-5p in acute myocardial infarction by targeting MXD1 [PDF]
Journal of Cardiothoracic SurgeryBackground Acute myocardial infarction (AMI) occurs rapidly and is a major cause of death in patients with coronary artery disease (CAD). To explore new biomarkers of AMI and its pathogenesis.
Shanshan Liu, Jing Han, Shufang Gao
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miR-210 is essential to retinal homeostasis in fruit flies and mice. [PDF]
Biol DirectBackground miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseases and cancer. Recently, new roles
Colaianni D +13 more
europepmc +3 more sources
miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages [PDF]
Frontiers in ImmunologyIntroductionMacrophages play fundamental roles in immune regulation and tissue homeostasis, serving as one of the primary cell types that orchestrate tissue repair after injury.
Carmen Alexandra Neculachi +16 more
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MiR-210 promotes bone formation in ovariectomized rats by regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells through downregulation of EPHA2 [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Purpose In osteoporosis, the balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) is disrupted. The osteogenic differentiation of bone marrow MSCs (BMSCs) is important for improving osteoporosis.
Lijue Ren +5 more
doaj +2 more sources
Roles of miR-210 in the pathogenesis of pre-eclampsia
Archives of Medical Science, 2018 Introduction This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia.
Jiyun Li, Guimei Wu, Yanmin Cao, Zhi Hou
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Elevation of circulating miR-210-3p in high-altitude hypoxic environment [PDF]
Frontiers in Physiology, 2016 Background: The induction of miR-210-3p, a master hypoxamir, is a consistent feature of the hypoxic response in both normal and malignant cells. However, whether miR-210-3p acts as a circulating factor in response to a hypoxic environment remains unknown.
Yan eYan +10 more
doaj +3 more sources
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
core +8 more sources
Involvement of upregulation of miR-210 in a rat epilepsy model
Neuropsychiatric Disease and Treatment, 2016 Licheng Chen, Hao Zheng, Shimeng Zhang Neurological Department of Internal Medicine, Linyi People’s Hospital of Shandong Province, Linyi, People’s Republic of China Abstract: Epilepsy is a common type of neurological disorder with ...
Chen L, Zheng H, Zhang S
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