Results 41 to 50 of about 4,858 (119)

Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis. [PDF]

Am J Physiol Endocrinol Metab, 2019
Endometriosis is a gynecologic disease common among reproductive-aged women caused by the growth of endometrial tissue outside the uterus. Altered expression of numerous genes and microRNAs has been reported in endometriosis. Steroidogenic factor 1 (SF-1), an essential transcriptional regulator of multiple genes involved in estrogen biosynthesis, is ...
Hu Z, Mamillapalli R, Taylor HS.
europepmc   +3 more sources

Circ_0070203 Promotes Epithelial Mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis [PDF]

, 2021
Abstract Background: Ovarian serous cystadenocarcinoma (OC) is a common malignant gynecological tumor that is found in women. Metastasis of ovarian cancer cells are the main causes of poor prognosis. Cell-acquired invasiveness is accompanied by the loss of epithelial features and gain of a mesenchymal phenotype, through a process known as ...
Qiong Tang, Huiting Wen, Xiaoli Chen, Xiushu Xu, Xiaoer Chen, Yu Fang, Yingshan Gao, Liu longyang, Jing Li   +8 more
openaire   +1 more source

Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression [PDF]

Scientific Reports, 2016
AbstractMicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. Our study aims to investigate potential miRNA biomarkers in GBM. Sixty GBM patients, which were given temozolomide (TMZ) chemotherapy and recurrent radiotherapy, were recruited.
Yong-tao Gao, Xiao-bing Chen, Hong-lin Liu   +2 more
openaire   +2 more sources

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation [PDF]

Biochemical Pharmacology, 2017
Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20-25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination caused by CYP2D6 genetic variants were reported. However, little is known about the potential modulation of
Linjuan, Zeng, Yinting, Chen, Yong, Wang, Li-Rong, Yu, Bridgett, Knox, Jiwei, Chen, Tieliu, Shi, Si, Chen, Zhen, Ren, Lei, Guo, Yuanfeng, Wu, David, Liu, Kaihong, Huang, Weida, Tong, Dianke, Yu, Baitang, Ning   +15 more
openaire   +2 more sources

Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B

Stem Cell Research & Therapy, 2019
Background Human bone marrow-derived mesenchymal stem cells (HBMSCs) are characterized by multiple differentiation potential and potent self-renewal ability, yet much remains to be elucidated on what determines these properties. Long-chain noncoding RNAs
Bo Jia, Zhiping Wang, Xiang Sun, Jun Chen, Jianjiang Zhao, Xiaoling Qiu   +5 more
doaj   +1 more source

Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling

Molecular Therapy: Nucleic Acids, 2020
To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on the expression of microRNAs (miRNAs) in the lung.
Xuemin Gao, Dingjie Xu, Shumin Li, Zhongqiu Wei, Shifeng Li, Wenchen Cai, Na Mao, Fuyu Jin, Yaqian Li, Xue Yi, Heliang Liu, Hong Xu, Fang Yang   +12 more
doaj   +1 more source

Endogenous and viral microRNAs in nasal secretions of water buffaloes (Bubalus bubalis) after Bubaline alphaherpesvirus 1 (BuHV-1) challenge infection

Veterinary Research, 2023
Bubaline alphaherpesvirus 1 (BuHV-1) is a pathogen of water buffaloes responsible for economic loss worldwide. MicroRNAs (miRNAs) regulate gene expression produced by alphaherpesviruses and hosts. This study aimed at (a) unravelling the ability of BuHV-1
Cristina Lecchi, Fabrizio Ceciliani, Stefano Petrini, Giovanna Cappelli, Carlo Grassi, Anna Balestrieri, Giorgio Galiero, Ester DeCarlo, Gaspare Salvi, Filippo Panzeri, Chiara Gini, Alessandra Cafiso, Alessandro Agazzi, Alessandra Martucciello   +13 more
doaj   +1 more source

CircASPH Promotes Hepatocellular Carcinoma Progression Through Methylation and Expression of HAO2

Frontiers in Oncology, 2022
CircRNAs have been reported to be related to hepatocellular carcinoma (HCC) development. Limited studies have revealed the expression profile of circRNAs in tumor and para-tumor normal samples in HCC patients.
Han Zhuo, Jinguo Xia, Jin Zhang, Junwei Tang, Sheng Han, Qitong Zheng, Deming Zhu, Feihong Zhang, Zhenggang Xu, Dongwei Sun, Zhongming Tan, Chen Wu   +11 more
doaj   +1 more source

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Molecular Cancer, 2019
Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown.
Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang   +13 more
doaj   +1 more source

Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p

BMC Cancer, 2019
Background Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal cells. However, their clinical significance and biological functions in breast cancer remain unknown. Methods RNA sequencing data of breast cancer was obtained from the
Bin Xiao, Daxiang Chen, Quan Zhou, Jianfeng Hang, Weiyun Zhang, Zhenzhan Kuang, Zhaohui Sun, Linhai Li   +7 more
doaj   +1 more source