Results 1 to 10 of about 47,292 (192)

The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer [PDF]

Journal of Advanced Research, 2022
Introduction: The prognosis for cervical cancer (CC) patients with lymph node metastasis (LNM) is extremely poor. Lipid droplets (LDs) have a pivotal role in promoting tumor metastasis.
Chunliang Shang, Yuan Li, Tianhui He, Yuandong Liao, Qiqiao Du, Pan Wang, Jie Qiao, Hongyan Guo   +7 more
doaj   +5 more sources

lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p [PDF]

BMC Molecular and Cell Biology, 2022
Background Dysregulation of ACTA2-AS1 and miR-532-5p and their functions in various cancers have been widely reported. Their potential of serving as biomarkers in triple-negative breast cancer (TNBC) remains unknown.
Yi Peng, Xiaoxi Huang, Hongmei Wang
doaj   +5 more sources

Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1 [PDF]

Open Medicine
This study is to probe into the meaning of serum miR-532-5p in nontraumatic osteonecrosis of the femoral head (ONFH), and a molecular mechanism of miR-532-5p in the development of nontraumatic ONFH.
Shang Peng, Liu Ying, Ren Jie, Liu Qingqing, Song Haobo, Jia Junqing, Liu Qiang   +6 more
doaj   +5 more sources

The diagnostic value of circulating miR-532-5p in patients with asymptomatic carotid artery stenosis and its predictive significance for the occurrence of cerebral ischaemic events [PDF]

Archives of Medical Science, 2020
Introduction Circulating microRNAs (miRNAs) are widely identified as promi­sing and novel biomarkers for the diagnosis of human diseases. This study investigated the clinical value of miR-532-5p for asymptomatic carotid artery stenosis (CAS) patients and
Deyong Du, Jing Liu, Chengcheng Liu, Zefu Li, Yang Gao, Wensheng Zhang, Haitao Zhang   +6 more
doaj   +5 more sources

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis. [PDF]

Exp Mol Med, 2022
As the most prevalent bone tumor in children and adolescents, the pathogenesis and metastasis of osteosarcoma (OS) remain largely unclear. Here, we investigated the expression and function of a novel circular RNA (circRNA), circROCK1-E3/E4, which is back-
Liu Y, Qiu G, Luo Y, Li S, Xu Y, Zhang Y, Hu J, Li P, Pan H, Wang Y.   +9 more
europepmc   +4 more sources

lncRNA MEG3 Promotes PDK4/GSK-3β/β-Catenin Axis in MEFs by Targeting miR-532-5p. [PDF]

Oxid Med Cell Longev, 2023
Studies reported the positive and negative osteogenic effects of MEG3 in mesenchymal stem cells (MSCs). This study aims at clarifying the osteogenic potential of MEG3 and the underlying mechanism.
Yang YY, Deng YX, Yao XT, Luo HH, He WG, Cao XL, Chen RC, He BC, Jiang HT, Wang J.   +9 more
europepmc   +4 more sources

miR-532-5p promotes breast cancer proliferation and migration by targeting RERG. [PDF]

Exp Ther Med, 2020
Aberrant expression of microRNAs (miRNAs/miRs) mediates the initiation and progression of breast cancer. Therefore, it is important to investigate the molecular mechanisms of miRNAs and their effects on breast cancer progression.
Huang L, Tang X, Shi X, Su L.
europepmc   +5 more sources

Exosomal miR-532-5p induced by long-term exercise rescues blood-brain barrier function in 5XFAD mice via downregulation of EPHA4. [PDF]

Aging Cell, 2023
The breakdown of the blood–brain barrier, which develops early in Alzheimer's disease (AD), contributes to cognitive impairment. Exercise not only reduces the risk factors for AD but also confers direct protection against cognitive decline.
Liang X, Fa W, Wang N, Peng Y, Liu C, Zhu M, Tian N, Wang Y, Han X, Qiu C, Hou T, Du Y.   +11 more
europepmc   +4 more sources

Long non-coding RNA LOC366613 alleviates the cerebral ischemic injury via regulating the miR-532-5p/phosphatase and tensin homolog axis. [PDF]

Bioengineered, 2021
Cerebral infarction (CI) has become a leading cause of death in China. Long non-coding RNAs (lncRNAs) are intensively involved in the progression of CI. Here, we aimed to investigate the effects of lncRNA LOC366613 (LOC366613) on cerebral I/R injury, as ...
Lu Z, Li L, Wei L, Cai J, Wu J.
europepmc   +5 more sources

MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis. [PDF]

Br J Cancer, 2018
Despite the fact that miRNAs play pivotal roles in various human malignancies, their molecular mechanisms influencing RCC are poorly understood. The expression of miRNAs from RCC and paired normal renal specimens was analysed by a combined computational ...
Zhai W, Ma J, Zhu R, Xu C, Zhang J, Chen Y, Chen Z, Gong D, Zheng J, Chen C, Li S, Li B, Huang Y, Xue W, Zheng J.   +14 more
europepmc   +5 more sources