Results 21 to 30 of about 5,056 (201)

Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. [PDF]

Biosci Rep, 2018
Circular RNAs (circRNAs), a new class of endogenous non-coding RNAs, have recently been known to play critical roles in various cellular biological processes, including tumorigenesis, in which they act as an miRNA sponge that regulates gene expression. Thus, revealing the functions of circRNAs in carcinogenesis and cancer development has been of great ...
Chang P, Wang F, Li Y.
europepmc   +3 more sources

Visualizing and Quantifying microRNA-Induced DNA Origami Separation at the Nanoscale. [PDF]

Angew Chem Int Ed Engl
Clinically relevant miRNA biomarkers trigger the disassembly of DNA origami dimers into monomers through a toehold‐mediated strand displacement reaction. High‐speed AFM was used to visualize this reaction in real time, while solid‐state nanopore measurements quantified the populations of dimers and monomers, as well as the resulting miRNA concentration,
Chau CCC, Gupta V, Heath GR, Wälti C, Actis P.   +4 more
europepmc   +3 more sources

MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis. [PDF]

Br J Cancer, 2018
Despite the fact that miRNAs play pivotal roles in various human malignancies, their molecular mechanisms influencing RCC are poorly understood.The expression of miRNAs from RCC and paired normal renal specimens was analysed by a combined computational and experimental approach using two published datasets and qRT-PCR assays.
Zhai W, Ma J, Zhu R, Xu C, Zhang J, Chen Y, Chen Z, Gong D, Zheng J, Chen C, Li S, Li B, Huang Y, Xue W, Zheng J.   +14 more
europepmc   +4 more sources

A Distinct Population of Mitochondrial miRNA in Human Male Skeletal Muscle Assessed Before and After Exercise. [PDF]

FASEB J
Here, we report that mitochondria from human skeletal muscle contain a select population of 127 microRNAs, including hsa‐miR‐146b‐5p whose expression tended to be altered in the hours following a single bout of endurance exercise. These findings suggest that mitochondria‐localized miRNAs may play a role in mediating the beneficial adaptive responses to
Silver JL, Hiam D, Loke S, Croft L, Soria M, Trewin AJ, Nielsen S, Lamon S, Wadley GD.   +8 more
europepmc   +2 more sources

Serum Expression Levels of Certain miRNAs in Predicting Diagnosis, Prognosis, and Response to Chemotherapy in Malignant Pleural Mesothelioma

Balkan Medical Journal, 2022
Background: miRNAs are involved in tumor pathogenesis and can therefore be determined in the primary tumor, plasma and serum, and body fluids. As in various cancers, their role in the diagnosis, prognosis, and treatment of patients with malignant pleural
Muzaffer Metintaş, Güntülü Ak, Cansu Özbayer, Filiz Boğar, Selma Metintaş   +4 more
doaj   +1 more source

MicroRNA‐532‐5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2

Kaohsiung Journal of Medical Sciences, 2020
The dysregulation of miR‐532‐5p is involved in the development of several cancers. Nevertheless, the roles of miR‐532‐5p in osteosarcoma (OS) have yet to be illuminated.
Yong Ma, Hai‐Xia Zhao, Yin‐Ju Shi, Ming‐Guo Cheng   +3 more
doaj   +1 more source

High Expression of miR-532-5p, a Tumor Suppressor, Leads to Better Prognosis in Ovarian Cancer Both In Vivo and In Vitro. [PDF]

Mol Cancer Ther, 2016
Abstract Ovarian cancer is the leading cause of death for gynecologic cancers, ranking fifth overall for cancer-related death among women. The identification of biomarkers and the elucidation of molecular mechanisms for improving treatment options have received extensive efforts in ovarian cancer research.
Wang F, Chang JT, Kao CJ, Huang RS.
europepmc   +4 more sources

Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling

Antioxidants, 2021
Hypertrophic and hypoxic visceral adipose tissue (VAT) secretes proinflammatory cytokines promoting insulin resistance (IR), prediabetes and type 2 diabetes (T2DM) microRNAs (miRNAs) are markers of metabolic disorders regulating genes critical for e.g ...
Justyna Strycharz, Adam Wróblewski, Andrzej Zieleniak, Ewa Świderska, Tomasz Matyjas, Monika Rucińska, Lech Pomorski, Piotr Czarny, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska   +10 more
doaj   +1 more source

Downregulation of circ-PSMB6 suppresses NSCLC progression and metastasis through sponging miR-532-5p and regulating EZH1 expression [PDF]

, 2021
Abstract Background: Accumulating reports showed how circular RNAs (circRNAs) act importantly during tumor progression via regulating gene expression, but regulatory mechanisms remain largely unknown. Current investigation clarified circRNA regulatory mechanisms in non-small cell lung cancer (NSCLC).Methods: High-throughput sequencing and ...
Mingming Jin, Junqian Zhang, Yue Wu, Yitian Dai, Gang Huang   +4 more
openaire   +1 more source

Cigarette Smoking Alters the Expression of Circulating microRNAs and Its Potential Diagnostic Value in Female Lung Cancer Patients

Biology, 2021
Cigarette smoking is a known risk factor for the development of lung cancer. We investigated whether circulating microRNA expression levels and their potential diagnostic value are affected by cigarette smoking in adenocarcinoma (AD) patients and healthy
Eric Gustavo Ramírez-Salazar, Luis Vicente Gayosso-Gómez, Renata Baez-Saldaña, Ramcés Falfán-Valencia, Rogelio Pérez-Padilla, Anjarath L. Higuera-Iglesias, María E. Vázquez-Manríquez, Blanca Ortiz-Quintero   +7 more
doaj   +1 more source