Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets [PDF]
MedComm, Volume 7, Issue 6, June 2026.Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang +7 more
wiley +2 more sources
Comprehensive analysis of circular RNA expression dynamics and competitive endogenous RNA network mechanisms during postnatal liver development in juvenile goats [PDF]
Animal BioscienceObjective This study analyzes the dynamic expression profile and functional mechanisms of circular RNA (circRNA) in the liver of young goats during development from birth to the early weaning stage.
Qing Li +4 more
doaj +2 more sources
Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner [PDF]
, 2022 Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there is no data on its role in the sensitivity of OC cells to DDP.
Yan Huang (46805), Yuan Gao (159945)
core +1 more source
The Effect of miR-34a-5p and miR-145-5p Ectopic Expression on Cell Proliferation and Target Gene Expression in the MDA-MB-231 Cell Line [PDF]
, 2021 Aim:It was aimed to investigate the effect of miR-34a-5p and miR-145-5p on breast cancer cell line MDA-MB-231 and to determine the expression of target genes of these microRNAs (miRNAs).Materials and Methods:Firstly, literature search and in silico ...
Emre ÖZGÜR +5 more
core +1 more source
SNHG1-miR-186-5p-YY1 feedback loop alleviates hepatic ischemia/reperfusion injury [PDF]
, 2022 As a common cause of liver injury, hepatic ischemia/reperfusion injury (HIRI) happens in various clinical conditions including trauma, hepatectomy and liver transplantation.
Qiang Sun (225630) +5 more
core +1 more source
MiR-942-5p regulates the expression of CST1. [PDF]
, 2023 (A) Conserved binding sites of four miRNAs to CST1 sequences. (B) Expression of miR-942-5p in 7 cell lines. (C) Expression of miR-942-5p after transfection of mimics. (D) Expression of miR-942-5p after transfection of inhibitor.
Yi Zhang (9093) +9 more
core +1 more source
Urinary exosomal microRNA profiling in intermediate-risk prostate cancer
Scientific Reports, 2021 MicroRNAs (miRNAs) of urine exosomes have emerged as biomarkers for urological cancers, owing to their high stability. MiRNAs have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence (BCR) and metastasis.
Mee Young Kim +5 more
doaj +1 more source
Analysis of the Inhibitory Effect of hsa-miR-145-5p and hsa-miR-203a-5p on Imatinib-Resistant K562 Cells by GC/MS Metabolomics Method [PDF]
, 2023 Imatinib (IM) resistance is considered to be a significant challenge in the management of chronic myeloid leukemia (CML). Previous studies have reported that hsa-miR-145-5p and hsa-miR-203a-5p can overcome IM resistance and hsa-miR-203a-5p can alter ...
Priyanka Singh (256412) +7 more
core +1 more source
Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19 [PDF]
, 2022 Xuewen Li,1 Yiting Wang,1 Qi Zhou,2 Junqi Pan,3 Jiancheng Xu1 1Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Pediatrics, First Hospital of Jilin University, Changchun, People ...
Li X, Pan J, Zhou Q, Wang Y, Xu J
core
Comprehensive analysis of the role of SFXN family in breast cancer
Open Medicine, 2023 The sideroflexin (SFXN) family is a group of mitochondrial membrane proteins. Although the function of the SFXN family in mitochondria has been widely recognized, the expression levels, role, and prognostic value of this family in breast cancer (BC) have
Yuan Ding +3 more
doaj +1 more source