Results 21 to 30 of about 47,292 (192)

In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers [PDF]

Frontiers in Cell and Developmental Biology
Microplastics (MPs) are increasingly implicated in cancer biology through effects on gene expression, stress responses, and treatment susceptibility; however, causal links remain provisional.
Akmaral Baspakova, Afshin Zare, Nadiar M. Mussin, Nader Tanideh, Nader Tanideh, Kulyash R. Zhilisbayeva, Ramazon Safarzoda Sharoffidin, Roza Suleimenova, Gulden Yelgondina, Akmeiir E. Kaliyeva, Aigerim A. Umbetova, Ainur Zinaliyeva, Amin Tamadon, Amin Tamadon   +13 more
doaj   +2 more sources

Multiple microRNAs regulate tacrolimus metabolism through CYP3A5 [PDF]

, 2021
The CYP3A5 gene polymorphism accounts for the majority of inter-individual variability in tacmlimus pharmacokinetics. We found that the basal expression of CYP3A5 in donor grafts also played a significant role in tacrolimus metabolism under the same ...
Gu, Xiang-Qian, Ji, Hao, Liu, Jin-Chuan, Qin, Tian, Tang, Dan, Tang, Yuan-Jia, Wan, Ping, Wu, Ji, Xia, Qiang, Xue, Feng, Yang, Tai-Hua   +10 more
core   +1 more source

Selection of reference genes for quantitative analysis of microRNA expression in three different types of cancer.

PLoS ONE, 2022
MicroRNAs (miRNAs) are promising biomarkers in cancer research. Quantitative PCR (qPCR), also known as real-time PCR, is the most frequently used technique for measuring miRNA expression levels.
Yuliya A Veryaskina, Sergei E Titov, Mikhail K Ivanov, Pavel S Ruzankin, Anton S Tarasenko, Sergei P Shevchenko, Igor B Kovynev, Evgenij V Stupak, Tatiana I Pospelova, Igor F Zhimulev   +9 more
doaj   +2 more sources

miRNA Signatures in Sera of Patients with Active Pulmonary Tuberculosis. [PDF]

, 2013
Several studies showed that assessing levels of specific circulating microRNAs (miRNAs) is a non-invasive, rapid, and accurate method for diagnosing diseases or detecting alterations in physiological conditions.
Aloi, Francesco, Ambrosi, Alessandro, Bosu, Roberta, Cirillo, Daniela M, Codecasa, Luigi R, Goletti, Delia, Heinrich, Norbert, Matteelli, Alberto, Miotto, Paolo, Mwangoka, Grace, Norbis, Luca, Ntinginya, Elias N, Reither, Klaus, Sotgiu, Giovanni, Valente, Ilaria C   +14 more
core   +9 more sources

MicroRNA-532-5p is implicated in the regulation of osteoporosis by forkhead box O1 and osteoblast differentiation

BMC Musculoskeletal Disorders, 2020
Background MicroRNAs (miRNAs) are critical regulators in osteogenesis and cartilage formation. This study was designed to investigate whether miR-532-5p plays a role in the regulation of osteoporosis.
Xinyu Guo, Shijun Wei, Feng Xu, Xianhua Cai, Huasong Wang, Ran Ding   +5 more
doaj   +1 more source

Serum Expression Levels of Certain miRNAs in Predicting Diagnosis, Prognosis, and Response to Chemotherapy in Malignant Pleural Mesothelioma

Balkan Medical Journal, 2022
Background: miRNAs are involved in tumor pathogenesis and can therefore be determined in the primary tumor, plasma and serum, and body fluids. As in various cancers, their role in the diagnosis, prognosis, and treatment of patients with malignant pleural
Muzaffer Metintaş, Güntülü Ak, Cansu Özbayer, Filiz Boğar, Selma Metintaş   +4 more
doaj   +1 more source

MicroRNA‐532‐5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2

Kaohsiung Journal of Medical Sciences, 2020
The dysregulation of miR‐532‐5p is involved in the development of several cancers. Nevertheless, the roles of miR‐532‐5p in osteosarcoma (OS) have yet to be illuminated.
Yong Ma, Hai‐Xia Zhao, Yin‐Ju Shi, Ming‐Guo Cheng   +3 more
doaj   +1 more source

Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication [PDF]

Journal of Virology, 2015
ABSTRACT West Nile virus (WNV) is a mosquito-transmitted flavivirus that naturally circulates between mosquitos and birds but can also infect humans, causing severe neurological disease. The early host response to WNV infection in vertebrates primarily relies on the type I interferon pathway; however, recent studies suggest that ...
A. Slonchak, Rory Shannon, Gabor Pali, A. Khromykh   +3 more
semanticscholar   +4 more sources

Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling

Antioxidants, 2021
Hypertrophic and hypoxic visceral adipose tissue (VAT) secretes proinflammatory cytokines promoting insulin resistance (IR), prediabetes and type 2 diabetes (T2DM) microRNAs (miRNAs) are markers of metabolic disorders regulating genes critical for e.g ...
Justyna Strycharz, Adam Wróblewski, Andrzej Zieleniak, Ewa Świderska, Tomasz Matyjas, Monika Rucińska, Lech Pomorski, Piotr Czarny, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska   +10 more
doaj   +1 more source

Cigarette Smoking Alters the Expression of Circulating microRNAs and Its Potential Diagnostic Value in Female Lung Cancer Patients

Biology, 2021
Cigarette smoking is a known risk factor for the development of lung cancer. We investigated whether circulating microRNA expression levels and their potential diagnostic value are affected by cigarette smoking in adenocarcinoma (AD) patients and healthy
Eric Gustavo Ramírez-Salazar, Luis Vicente Gayosso-Gómez, Renata Baez-Saldaña, Ramcés Falfán-Valencia, Rogelio Pérez-Padilla, Anjarath L. Higuera-Iglesias, María E. Vázquez-Manríquez, Blanca Ortiz-Quintero   +7 more
doaj   +1 more source