Experimental procedures to identify and validate specific mRNA targets of miRNAs [PDF]
, 2015 Functionally matured microRNAs (miRNAs) are small single-stranded non-coding RNA molecules which are emerging as important post-transcriptional regulators of gene expression and consequently are central players in many physiological and pathological ...
Elton, Terry S., Yalowich, Jack C.
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Scientific Reports, 2022 Fragile X syndrome (FXS) is caused by a mutation in the FMR1 gene which can lead to a loss or shortage of the FMR1 protein. This protein interacts with specific miRNAs and can cause a range of neurological disorders.
Maryam Sotoudeh Anvari +9 more
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Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy [PDF]
, 2017 Exosomes participate in intercellular messaging by transporting bioactive lipid-, protein-and RNA-molecules and -complexes. The contents of the exosomes reflect the physiological status of an individual making exosomes promising targets for biomarker ...
Alen, Markku +10 more
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Expression of nonmuscle myosin IIC is regulated by non-canonical binding activity of miRNAs
iScience, 2023 Summary: The expression of mechanoresponsive nonmuscle myosin II (NMII)C is found to be inducible during tumor progression, but its mechanism is yet to be explored.
Kumarjeet Banerjee +6 more
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Adverse Intrauterine Environment and Cardiac miRNA Expression. [PDF]
, 2017 Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus.
Botting, Kimberley J +4 more
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Blood miRNAs Are Linked to Frequent Asthma Exacerbations in Childhood Asthma and Adult COPD
Non-Coding RNA, 2022 MicroRNAs have been independently associated with asthma and COPD; however, it is unclear if microRNA associations will overlap when evaluating retrospective acute exacerbations.
Anshul Tiwari +9 more
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Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome [PDF]
, 2018 Background: MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression changes of circulating miRNAs and
Abdul-Khaliq, Hashim +6 more
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Frontiers in Endocrinology, 2018 The reduced expression of solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) and hexokinase-2 (HK2) in skeletal muscle participates in insulin resistance of diabetes mellitus (DM).
João V. Esteves +5 more
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Systematic Assessment of Blood-Borne MicroRNAs Highlights Molecular Profiles of Endurance Sport and Carbohydrate Uptake [PDF]
, 2019 Multiple studies endorsed the positive effect of regular exercise on mental and physical health. However, the molecular mechanisms underlying training-induced fitness in combination with personal life-style remain largely unexplored.
Backes, Christina +9 more
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MicroRNA Expression Profiling in Clear Cell Renal Cell Carcinoma: Identification and Functional Validation of Key miRNAs. [PDF]
PLoS ONE, 2015 This study aims to profile dysregulated microRNA (miRNA) expression in clear cell renal cell carcinoma (ccRCC) and to identify key regulatory miRNAs in ccRCC.miRNA expression profiles in nine pairs of ccRCC tumor samples at three different stages and the
Haowei He +11 more
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