Results 61 to 70 of about 47,292 (192)

Identification of biomarkers and construction of a microRNA‑mRNA regulatory network for clear cell renal cell carcinoma using integrated bioinformatics analysis.

PLoS ONE, 2021
With the recent research development, the importance of microRNAs (miRNAs) in renal clear cell carcinoma (CCRCC) has become widely known. The purpose of this study is to screen out the potential biomarkers of renal clear cell carcinoma (CCRCC) by ...
Miaoru Han, Haifeng Yan, Kang Yang, Boya Fan, Panying Liu, Hongtao Yang   +5 more
doaj   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours

, 2016
Familial adenomatous polyposis (FAP) is rare affecting 1 in 10,000 people and a subset (10%) are at risk of myofibroblastic desmoid tumours (DTs) after colectomy to prevent cancer. DTs are a major cause of morbidity and mortality.
Clark, SK, Feakins, R, Giannoulatou, E, Jeffery, R, Lewis, A, Lindsay, JO, Silver, A, Thompson, H, Walton, SJ, Yau, C   +9 more
core   +1 more source

Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs [PDF]

, 2019
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures.
Backes, Christina, Berg, Daniela, Deuschle, Christian, Deutscher, Stephanie, Fehlmann, Tobias, Gogol, Manfred, Gurlit, Simone, Keller, Andreas, Keller, Verena, Kern, Fabian, Lenhof, Hans-Peter, Ludwig, Nicole, Maetzler, Walter, Meese, Eckart, Metzger, Florian, Schulte, Claudia, Suenkel, Ulrike, von Thaler, Anna-Katharina   +17 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Placental microRNA expression associates with birthweight through control of adipokines: results from two independent cohorts

Epigenetics, 2021
MicroRNAs are non-coding RNAs that regulate gene expression post-transcriptionally. In the placenta, the master regulator of foetal growth and development, microRNAs shape the basic processes of trophoblast biology and specific microRNA have been ...
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Todd M. Everson, Maya Deyssenroth, Ke Hao, Jia Chen, Margaret R Karagas, Dong Pei, Devin C Koestler, Carmen J Marsit   +10 more
doaj   +1 more source

Basal Plane Activation of SnS2 Thin‐Film by Fluorine Doping for Selective Solar‐Driven CO2 Reduction With Enhanced Quantum Efficiency

Advanced Science, EarlyView.
The synergistic effect of fluorine doping and sulfur vacancies boosts the activity of the active sites without active‐site modulation, leading to enhanced CO2 photoreduction efficiency and a selectivity switch from CH4 to CO on tin disulfide continuous thin films. ABSTRACT Photocatalytic conversion of CO2 into value‐added fuels offers a viable approach
Tadios Tesfaye Mamo, Mohammad Qorbani, Adane Gebresilassie Hailemariam, Putikam Raghunath, Che‐Men Chu, Wen‐Hsin Yuan, Amr Sabbah, Yen‐Yu Wang, Shuo‐Yun Chang, Ming‐Chang Lin, Wei‐Yen Woon, Yu‐Jung Lu, Heng‐Liang Wu, Ken‐Tsung Wong, Kuei‐Hsien Chen, Li‐Chyong Chen   +15 more
wiley   +1 more source

Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma

iScience
Summary: The efficacy of hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin (OXA) and 5-fluorouracil (5-Fu) for treating advanced perihilar cholangiocarcinoma (pCCA) has been demonstrated, yet the survival benefits of HAIC for pCCA patients ...
Shijie Fu, Haizhen Du, Yuyang Dai, Kanglian Zheng, Guang Cao, Liang Xu, Yujie Zhong, Chuanxin Niu, Yan Kong, Xiaodong Wang   +9 more
doaj   +1 more source

Association of recurrent venous thromboembolism and circulating microRNAs

Clinical Epigenetics, 2019
Background Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to ...
Xiao Wang, Kristina Sundquist, Peter J. Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A. Memon, Jan Sundquist, Bengt Zöller   +7 more
doaj   +1 more source

MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1

Aging, 2021
We investigated the function of microRNA (miR)-532-5p in cerebral ischemia-reperfusion injury (CI/RI) and the underlying mechanisms using oxygen-glucose deprivation and reperfusion (OGD/R)-treated SH-SY5Y cells and middle cerebral artery occlusion (MCAO)
Yuanyuan Shi, ZhongQuan Yi, PanWen Zhao, Yun Xu, PingLei Pan   +4 more
semanticscholar   +1 more source