Results 61 to 70 of about 4,926 (186)

Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication [PDF]

Journal of Virology, 2016
ABSTRACT West Nile virus (WNV) is a mosquito-transmitted flavivirus that naturally circulates between mosquitos and birds but can also infect humans, causing severe neurological disease. The early host response to WNV infection in vertebrates primarily relies on the type I interferon pathway; however, recent studies suggest that ...
Slonchak, Andrii, Shannon, Rory P, Pali, Gabor, Khromykh, Alexander A   +3 more
openaire   +3 more sources

Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours

, 2016
Familial adenomatous polyposis (FAP) is rare affecting 1 in 10,000 people and a subset (10%) are at risk of myofibroblastic desmoid tumours (DTs) after colectomy to prevent cancer. DTs are a major cause of morbidity and mortality.
Clark, SK, Feakins, R, Giannoulatou, E, Jeffery, R, Lewis, A, Lindsay, JO, Silver, A, Thompson, H, Walton, SJ, Yau, C   +9 more
core   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

Chiral Acoustic Phonon and Conservation of Pseudoangular Momentum in α‐Quartz

Advanced Materials, EarlyView.
Chiral acoustic phonons in α‐quartz are probed via Brillouin light scattering, exploiting the photon's helicity and the crystal's handedness. The interaction obeys a selection rule arising from pseudoangular momentum conservation, enabling direct optical access to phonon chirality in nonsymmorphic crystals.
Changsoo Kim, In‐Kook Hwang, Kyoung‐Woong Moon, Kyongmo An, Kyung‐Jin Lee, Jae‐Hyeon Ko, Byong‐Guk Park, Kwang‐Yong Choi, Chanyong Hwang   +8 more
wiley   +1 more source

Placental microRNA expression associates with birthweight through control of adipokines: results from two independent cohorts

Epigenetics, 2021
MicroRNAs are non-coding RNAs that regulate gene expression post-transcriptionally. In the placenta, the master regulator of foetal growth and development, microRNAs shape the basic processes of trophoblast biology and specific microRNA have been ...
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Todd M. Everson, Maya Deyssenroth, Ke Hao, Jia Chen, Margaret R Karagas, Dong Pei, Devin C Koestler, Carmen J Marsit   +10 more
doaj   +1 more source

Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs [PDF]

, 2019
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures.
Backes, Christina, Berg, Daniela, Deuschle, Christian, Deutscher, Stephanie, Fehlmann, Tobias, Gogol, Manfred, Gurlit, Simone, Keller, Andreas, Keller, Verena, Kern, Fabian, Lenhof, Hans-Peter, Ludwig, Nicole, Maetzler, Walter, Meese, Eckart, Metzger, Florian, Schulte, Claudia, Suenkel, Ulrike, von Thaler, Anna-Katharina   +17 more
core   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma

iScience
Summary: The efficacy of hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin (OXA) and 5-fluorouracil (5-Fu) for treating advanced perihilar cholangiocarcinoma (pCCA) has been demonstrated, yet the survival benefits of HAIC for pCCA patients ...
Shijie Fu, Haizhen Du, Yuyang Dai, Kanglian Zheng, Guang Cao, Liang Xu, Yujie Zhong, Chuanxin Niu, Yan Kong, Xiaodong Wang   +9 more
doaj   +1 more source

Association of recurrent venous thromboembolism and circulating microRNAs

Clinical Epigenetics, 2019
Background Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to ...
Xiao Wang, Kristina Sundquist, Peter J. Svensson, Hamideh Rastkhani, Karolina Palmér, Ashfaque A. Memon, Jan Sundquist, Bengt Zöller   +7 more
doaj   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source