Results 71 to 80 of about 47,292 (192)

Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2018
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease. While genetics and other factors contribute to ALS pathogenesis, critical knowledge is still missing and validated biomarkers for monitoring the disease activity ...
Maria Liguori, Nicoletta Nuzziello, Alessandro Introna, Arianna Consiglio, Flavio Licciulli, Eustachio D’Errico, Antonio Scarafino, Eugenio Distaso, Isabella L. Simone   +8 more
doaj   +1 more source

Assessment Of Epsteın Barr Vırus Molecular Polymorphısm And Tumor Bıomarkers Assocıated Wıth Non- Hodgkın’s Lymphoma In Iraqı Patıents [PDF]

, 2022
The current study was conducted to evaluate the Epstein-Barr virus molecular polymorphism and tumor biomarkers associated with non-Hodgkin's lymphoma in Iraqi patients.
Aboomeıma, Wiqar Adnan Azeez
core  

MicroRNA-532-5p regulates oxidative stress and insulin secretion damage in high glucose-induced pancreatic β cells by downregulating the expression levels of CCND1

Molecular Medicine Reports, 2021
Diabetes mellitus is a metabolic disorder caused by insufficient insulin secretion. The expression of microRNA (miR)-532-5P is downregulated in diabetes, but its specific role in diabetes has not yet been elucidated.
Zhibiao Zhong, Weilan Su, Hongmei Chen
semanticscholar   +1 more source

Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra‐Targeted Tumor α‐Therapy

Exploration, EarlyView.
Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Yifei Jiang, Huizhen Yang, Guoping Jia, Wangxi Hai, Rongyi Huang, Peng Wang, Min Zhang, Danni Li, Yizhou Chen, Xiao Li, Biao Li, Chunfu Zhang   +11 more
wiley   +1 more source

Differential Pattern of Circulating MicroRNA Expression in Patients with Intracranial Atherosclerosis

Biomedicines
Background: Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke, yet fundamental studies regarding epigenetic regulation of ICAS are lacking.
Marine M. Tanashyan, Anton A. Raskurazhev, Alla A. Shabalina, Andrey S. Mazur, Vladislav A. Annushkin, Polina I. Kuznetsova, Sergey N. Illarioshkin, Mikhail A. Piradov   +7 more
doaj   +1 more source

Electrical pulse stimulation-induced tetanic exercise simulation increases the secretion of extracellular vesicles from C2C12 myotubes [PDF]

, 2023
Extracellular vesicles (EVs) released into the blood during exercise mediate its whole-body health effects. The differentiation of EVs released by skeletal muscle cells in vivo from those released by other cells is challenging, therefore, it is unclear ...
Akiyama, Hirokazu, Honda, Hiroyuki, Murata, Akari, Shimizu, Kazunori   +3 more
core   +1 more source

Integrating Single‐Cell and Spatial Transcriptomes in HGSOC to Decipher the Metastasis‐Associated Biomarkers

iNew Medicine, EarlyView.
ABSTRACT High‐grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of ovarian cancer. This study aimed to identify peritoneal metastasis‐associated biomarkers of HGSOC to provide directions for subsequent treatment. Transcriptome data were extracted from the GEO database and literature. Differential expression analysis,
Jing Zhu, Zhicheng Yu, Yang Zhang, Hui Hong, Xiaoli Wang, Shan Jiang, Ying Zhou, Cheng Peng, Hongbo Chen   +8 more
wiley   +1 more source

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a “tunneled” course under a bridge of myocardium:
Tracey McLaughlin, Ingela Schnittger, Anna Nagy, Elizabeth Zanley, Yue Xu, Yanqiu Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks   +10 more
doaj   +1 more source

Roles of microRNA on cancer cell metabolism [PDF]

, 2012
Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death.
Bing Chen, Hongbin Li, Pengbo Yang, Shufang Liang, Xia Zhao, Xiao Zeng, Xinyu Liu   +6 more
core   +1 more source

Role of miRNA-mRNA Interaction in Neural Stem Cell Differentiation of Induced Pluripotent Stem Cells [PDF]

, 2020
miRNA regulates the expression of protein coding genes and plays a regulatory role in human development and disease. The human iPSCs and their differentiated progenies provide a unique opportunity to identify these miRNA-mediated regulatory mechanisms ...
Blangero, John, Curran, Joanne E., De Leon, Erica, Glahn, David C., Howard, Tom E., Kumar, Satish, Leandro, Ana C., Lehman, Donna M., Williams-Blangero, Sarah   +8 more
core   +2 more sources