Results 41 to 50 of about 6,191 (242)

Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts [PDF]

, 2014
Metabolic and oxidative stresses induce physiological adaptation processes, disrupting a finely tuned, coordinated network of gene expression. To better understand the interplay between the mRNA and miRNA transcriptomes, we examined how two distinct ...
Akin, Andrea Vereczkei, APA, Bensaude, Cao, de Nadal, Garbett, Garbett, Garcia, Geraldo, Gibson, Glorioso, Horvath, Hulsmans, Inui, Jacobs, Kang, Katakowski, Krassimira A. Garbett, Kutty, Károly Mirnics, Malan-Muller, Manier, Manier, Marroquin, Michel, Mirnics, Mirnics, Naydenov, Raff, Reich, Richard C. Shelton, Subramanian, Sára Kálmán, Takahashi, Tsai, Unger, Wang, Željka Korade   +38 more
core   +1 more source

LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis [PDF]

Breast Cancer Research and Treatment, 2021
Breast cancer (BC) is the most prevalent cancer in women with an estimated incidence of 10% and the leading cause of mortality due to its heterogenous property and high metastasis rate. Development of novel therapy is very necessary and requires an understanding of molecular mechanisms.
You-Quan Wang, Guo Huang, Juan Chen, Hong Cao, Wen-Ting Xu   +4 more
openaire   +2 more sources

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]

, 2018
Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia, Bozzoni, Irene, Caffarelli, Elisa, Capauto, Davide, Colantoni, Alessio, Laneve, Pietro, Lu, Lei, Morlando, Mariangela, Peruzzi, Giovanna, Santini, Tiziana, Shneider, Neil A.   +10 more
core   +2 more sources

CTGF promotes osteosarcoma angiogenesis by regulating miR-543/angiopoietin 2 signaling

Cancer Letters, 2017
Osteosarcoma is the most common primary solid tumor of bone. It has a high metastatic potential and occurs predominantly in adolescents and young adults. Angiopoietin 2 (Angpt2) is a key regulator in tumor angiogenesis, facilitating tumor growth and metastasis.
Wang, Li-Hong, Tsai, Hsiao-Chi, Cheng, Yu-Che, Lin, Chih-Yang, Huang, Yuan-Li, Tsai, Chun-Hao, Xu, Guo-Hong, Wang, Shih-Wei, Fong, Yi-Chin, Tang, Chih-Hsin   +9 more
openaire   +2 more sources

miR-543 functions as a tumor suppressor in glioma in vitro and in vivo. [PDF]

Oncol Rep, 2017
Gliomas are the most common primary central nervous system tumors and account for approximately 80% of malignant brain tumors. MicroRNAs (miRNAs) are a class of small non-coding, regulatory RNA molecules that mediate the expression levels of specific proteins.
Xu L, Yu J, Wang Z, Zhu Q, Wang W, Lan Q.   +5 more
europepmc   +4 more sources

A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator [PDF]

, 2015
International audienceMiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common ...
Bhajun, Ricky, Combe, Stéphanie, Ghorbel, Itebeddine, Gidrol, Xavier, Guyon, Laurent, Haguet, Vincent, Lajaunie, Christian, Obeid, Patricia, Pitaval, Amandine, Sulpice, Eric   +9 more
core   +3 more sources

Kinetics of the chromosome 14 microRNA cluster ortholog and its potential role during placental development in the pregnant mare [PDF]

, 2018
Background: The human chromosome 14 microRNA cluster (C14MC) is a conserved microRNA (miRNA) cluster across eutherian mammals, reported to play an important role in placental development.
Ball, Barry A, Carossino, Mariano, Daels, Peter, Dini, Pouya, Esteller-Vico, Alejandro, Loux, Shavahn C, Scoggin, Kirsten E   +6 more
core   +5 more sources

MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology [PDF]

, 2018
Indexación: Scopus.1Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile, 2National Institute of Environmental Health ...
Aguayo, F.I., Aliaga, E., Cidlowski, J.A., García-Pérez, M.A., García-Rojo, G., Gutiérrez, R.A., Moyano, T.C., Muñoz-Llanos, M., Pacheco, A., Rojas, P.S., Tejos-Bravo, M., Vidal, E.A., Xu, X.   +12 more
core   +1 more source

Gene-microRNA network module analysis for ovarian cancer [PDF]

, 2016
BACKGROUND: MicroRNAs (miRNAs) are involved in many biological processes by regulating post-transcriptional gene expression. The alterations of the regulatory pathways can cause different diseases including cancer.
Michael K. Ng, Shuqin Zhang
core   +2 more sources

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway. [PDF]

J Cancer, 2019
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as a sensitizer for oxaliplatin (L-OHP) chemoresistant CRC cells.
Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X.   +13 more
europepmc   +3 more sources