Results 121 to 130 of about 4,115 (133)

MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression

Biochemical and Biophysical Research Communications, 2018
Intracerebral haemorrhage (ICH) is a common and devastating cerebrovascular disease with high morbidity and mortality, and its pathophysiological mechanisms were complex and still unclear. Increasing researches reported that microRNAs (miRNAs) played an important role in ICH-induced brain injury and microglial activation. In this study, we investigated
Qiang, Guo, Hang, Su, Jian-Bo, He, Hui-Qi, Li, Juan-Juan, Sha   +4 more
openaire   +2 more sources

MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis

Biochemical and Biophysical Research Communications, 2016
Endothelial cell apoptosis contributes to cardiovascular diseases such as hypertension, atherosclerosis. MicroRNA regulates endothelial cell function but its role in endothelial cell apoptosis remains to be fully elucidated. This study aims to investigate the role of miR-590-5p in endothelial cell apoptosis and dissect the underlying mechanisms.Flow ...
Ping, Luo, Wei-Fang, Zhang, Zhao-Xin, Qian, Ling-Fang, Xiao, Hui, Wang, Tian-Tian, Zhu, Feng, Li, Chang-Ping, Hu, Zheng, Zhang   +8 more
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Chitosan/nano-hydroxyapatite/nano-zirconium dioxide scaffolds with miR-590-5p for bone regeneration

International Journal of Biological Macromolecules, 2018
Bone tissue engineering (BTE) relies on biocomposite scaffolds and bioactive molecules for bone regeneration. The present study was aimed to synthesize and characterize biocomposite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and nano‑zirconium dioxide (nZrO2) along with microRNA (miRNA) for BTE applications.
K, Balagangadharan, S, Viji Chandran, B, Arumugam, S, Saravanan, G, Devanand Venkatasubbu, N, Selvamurugan   +5 more
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MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer

Cancer Letters, 2017
YAP1, a transcription co-activator, mediates the biological functions of the Hippo pathway. YAP1 inactivation is involved in cell-cell contact inhibition. In various tumors, YAP1 is upregulated through multiple mechanisms, and it functions as an oncogene.
Chunlin Ou, Zhenqiang Sun, Xiayu Li, Xiaoling Li, Weiguo Ren, Zailong Qin, Xuemei Zhang, Weitang Yuan, Jia Wang, Wentao Yu, Shiwen Zhang, Qiu Peng, Qun Yan, Wei Xiong, Guiyuan Li, Jian Ma   +15 more
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Long noncoding RNA DUXAP8 regulates proliferation and apoptosis of ovarian cancer cells via targeting miR-590-5p

Human Cell, 2020
The aim of this study is to investigate the effect of lncRNA DUXAP8 on proliferation and apoptosis of ovarian cancer cells, and to explore its potential mechanism. DUXAP8 interfering and overexpressing cell lines were constructed and the cell proliferation and apoptosis were tested.
Qingyou Meng, Zhongliang Li, Jiaxue Pan, Xiaorong Sun   +3 more
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CircDUS2L (circ_0039908) promotes lung adenocarcinoma progression by upregulating PGAM1 by acting as a miR‐590‐5p molecular sponge

Journal of Biochemical and Molecular Toxicology, 2023
AbstractLung adenocarcinoma (LUAD) is usually found at the metastatic stage. Circular RNA dihydrouridine synthase 2‐like (DUS2L) (circDUS2L) has been discovered to be upregulated in LUAD. Nevertheless, the function of circDUS2L in LUAD has not been verified.
Qing Tian, Ying Guo, Jinfeng Liu, Chao Pang, Qiang Wang, Qi Xie, Jianke Li   +6 more
openaire   +2 more sources

lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions

International Immunopharmacology, 2020
Intrauterine adhesion (IUA) is one of the most common reproductive system diseases in women worldwide. The role of lncRNAs in multiple diseases has been confirmed, but the role and mechanism of lncRNA taurine upregulated gene 1 (TUG1) in the progression of IUA need to be elucidated further.
Ying, Ai, Mingqing, Chen, Jia, Liu, Li, Ren, Xuelan, Yan, Yun, Feng   +5 more
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Melatonin‐mediated miR‐526b‐3p and miR‐590‐5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells

Journal of Pineal Research, 2018
AbstractBone marrow‐derived mesenchymal stem cells (BMSCs), with inherent chondrogenic differentiation potential appear to be ideally suited for therapeutic use in cartilage regeneration. Accumulating evidence has demonstrated that melatonin can promote chondrogenic differentiation in human BMSCs. However, little is known about the mechanism. MicroRNAs
Zizhao Wu, Xianjian Qiu, Bo Gao, Chengjie Lian, Yan Peng, Anjing Liang, Caixia Xu, Wenjie Gao, Liangming Zhang, Peiqiang Su, Limin Rong, Dongsheng Huang   +11 more
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MiR-590-5p Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Radiation by Blocking Autophagy via Targeting ATG3

SSRN Electronic Journal, 2019
Background: Resistance against radio therapy is growing concern in treating patients of pancreatic cancer (PC). Improving our depth with regards to mechanisms involved in radio resistance could help in developing strategies for increasing patient's response to this therapy.
Fazhao Li, Jun He, Susan Liu, Yawei Zhang, Leping Yang   +4 more
openaire   +1 more source

Circ_0069718 promotes the progression of breast cancer by up-regulating NFIB through sequestering miR-590-5p.

Mammalian genome : official journal of the International Mammalian Genome Society, 2022
Researches indicate that circular RNAs are dysregulated in breast cancer (BC) and play a critical role in regulating the malignant phenotype of cancer cells. Herein, the goal of this work was to investigate the role and mechanism of circ_0069718 in BC development.
Yongsheng, Zhao, Xiaocha, Ma, Weihua, Shi   +2 more
openaire   +1 more source