Results 41 to 50 of about 6,232 (244)
Frontiers in Immunology, 2020 IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by the deposition of IgA1 and underglycosylated IgA1 aggregates in the mesangial area, which may be accompanied by the ...
Chan Liu +5 more
doaj +1 more source
Prospects for Treatment of Idiopathic Pulmonary Fibrosis
Архивъ внутренней медицины, 2022 Idiopathic pulmonary fibrosis (IPF) is a severe, progressive lung disease of unknown etiology with an average worldwide prevalence of 15 per 100,000. According to the etiology, IPF is classified into sporadic, syndromic, and familial cases.
R. N. Mustafin
doaj +1 more source
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression [PDF]
, 2016 MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer,
Armaiz-Pena, +18 more
core +2 more sources
Molecular genetics of idiopathic pulmonary fibrosis
Вавиловский журнал генетики и селекции, 2022 Idiopathic pulmonary fibrosis (IPF) is a severe progressive interstitial lung disease with a prevalence of 2 to 29 per 100,000 of the world’s population. Aging is a significant risk factor for IPF, and the mechanisms of aging (telomere depletion, genomic
R. N. Mustafin
doaj +1 more source
A validated microRNA profile with predictive potential in glioblastoma patients treated with bevacizumab [PDF]
, 2016 Purpose: We investigated whether microRNA expression data from glioblastoma could be used to produce a profile that defines a bevacizumab responsive group of patients.
Afonyushkin +44 more
core +1 more source
Data from miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death
, 2023 <div>Abstract<p>MicroRNAs (miRNA) are noncoding RNAs that regulate multiple cellular processes, including proliferation and apoptosis. We used microarray technology to identify miRNAs that were upregulated by non–small cell lung cancer (NSCLC) A549 cells in response to cisplatin (CDDP).
Guido Kroemer +15 more
openaire +1 more source
Differential expression of microRNAs in GH-secreting pituitary adenomas [PDF]
, 2010 Background The purpose of this study was to (1) identify specific miRNAs in growth hormones (GH)-secreting pituitary adenomas; (2) determine the relationship between the expression of these miRNAs and tumor size, somatostatin analogs ...
Zhi-Gang Mao +7 more
core +1 more source
Extracellular vesicle miRNAs in breast milk of obese mothers
Frontiers in Nutrition, 2022 BackgroundBreast milk has abundant extracellular vesicles (EVs) containing various biological molecules (cargo), including miRNAs. EVs are not degraded in the gastrointestinal system and circulation; thus, breast milk EVs (bEVs) are expected to interact ...
Young Eun Cho +10 more
doaj +1 more source
The potential of miR-630, an IGF1R regulator, as a predictive biomarker for HER2-targeted drugs. [PDF]
Journal of Clinical Oncology, 2013 620 Background: Innate or acquired resistance to current HER-targeting drugs indicates that their use for HER2-overexpressing breast cancer (BC) treatment may be compromised. miRNAs may have potential as diagnostic, prognostic and predictive biomarkers for treatment response, as well as therapeutic targets and replacement therapies.
Claire Corcoran +5 more
openaire +1 more source
HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation [PDF]
, 2015 Background: MicroRNAs (miRs) are an abundant class of small non-coding RNAs (~22 nt) that reprogram gene ex- pression by targeting mRNA degradation and translational disruption.
Da Sacco, Letizia +5 more
core +1 more source