Results 11 to 20 of about 480,809 (228)
Advances in Molecular Oncology, 2022 Introduction. Testicular germ cell tumor is a relatively rare disease. Its high social significance is due to the fact that this pathology occurs in young patients. The standard schemes of polychemotherapy determine the potential possibility of effective treatment for most of the patients even with an advanced disease.
M. S. Knyazeva +10 more
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Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer [PDF]
BMC Cancer, 2012 MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and ...
Schee Kristina +4 more
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Aging Cell, Volume 22, Issue 4, April 2023., 2023 miR‐229,64,65,66 family interacts with SKN‐1 to control DR/low‐IIS longevity. Abstract Several microRNAs have emerged as regulators of pathways that control aging. For example, miR‐228 is required for normal lifespan and dietary restriction (DR) mediated longevity through interaction with PHA‐4 and SKN‐1 transcription factors in Caenorhabditis elegans.
Latika Matai +6 more
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miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF [PDF]
Cellular and Molecular Life Sciences, 2014 Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that regulates brain development, synaptogenesis, memory and learning, as well as development of peripheral organs, such as angiogenesis in the heart and postnatal growth and repair of skeletal muscle.
Varendi, Kärt +3 more
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FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b [PDF]
Frontiers in Cell and Developmental Biology, 2020 Apoptosis plays an important role during development, control of tissue homeostasis and in pathological contexts. Apoptosis is executed mainly through the intrinsic pathway or the death receptor pathway, i.e., extrinsic pathway. These processes are tightly controlled by positive and negative regulators that dictate pro- or anti-apoptotic death receptor
Elena Coccia +13 more
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microRNA‐based diagnostic and therapeutic applications in cancer medicine
WIREs RNA, Volume 12, Issue 6, November/December 2021., 2021 microRNAs are short noncoding regulatory RNAs with important roles in cancer biology. microRNAs are informative biomarkers for early cancer detection and treatment decisions. microRNAs are being evaluated in clinical trials as new drugs for personalized cancer medicine.
Lorenzo F. Sempere +2 more
wiley +1 more source
microRNA strand selection: Unwinding the rules
WIREs RNA, Volume 12, Issue 3, May/June 2021., 2021 Summary of miRNA strand selection and regulatory mechanisms. Three major points of regulation for miRNA strand selection (1) altered miRNA processing by the Microprocessor complex (not shown) or Dicer, (2) remodeling of the miRNA duplex by nontemplated RNA modifications such as uridylation or A‐to‐I editing, and (3) changes in the strand preference of ...
Jeffrey C. Medley +2 more
wiley +1 more source
Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients [PDF]
British Journal of Cancer, 2015 Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC.Seven microRNAs (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429) were quantified in the serum of 180 ...
Xiaodan Meng +8 more
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Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome [PDF]
British Journal of Biomedical Science, 2022 Introduction: Alterations in certain microRNAs (miRNAs) and their target genes have reported in polycystic ovary syndrome (PCOS) and other disease of the female reproductive system, and so may be potential biomarkers. We hypothesised alterations in the prevalence of four miRNAs single nucleotide polymorphism (SNP) variants miR-126 rs4636297, miR-146a ...
Li, R. +6 more
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miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging [PDF]
Aging Cell, 2010 SummaryAging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically encoded repair systems. To better understand the genetic component of aging, many studies have addressed the gene and protein expression profiles of various aging model systems engaging different ...
Hackl, Matthias +27 more
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