Results 11 to 20 of about 1,588,382 (270)

Expression of miR-302a, miR-302b, miR-302c, miR-302d, miR-367, miR-371, miR-372, miR-373, miR-10b, miR-21 and miR-93 in cells of different histotypes of testicular germ cell tumors

Advances in Molecular Oncology, 2022
Introduction. Testicular germ cell tumor is a relatively rare disease. Its high social significance is due to the fact that this pathology occurs in young patients. The standard schemes of polychemotherapy determine the potential possibility of effective treatment for most of the patients even with an advanced disease.
M. S. Knyazeva, V. A. Zagoruiko, A. V. Khokhlova, I. V. Nazarova, A. V. Shalaev, E. I. Sidina, L. M. Zabegina, A. S. Artemyeva, A. K. Nosov, S. A. Protsenko, A. V. Malek   +10 more
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Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome [PDF]

British Journal of Biomedical Science, 2022
Introduction: Alterations in certain microRNAs (miRNAs) and their target genes have reported in polycystic ovary syndrome (PCOS) and other disease of the female reproductive system, and so may be potential biomarkers. We hypothesised alterations in the prevalence of four miRNAs single nucleotide polymorphism (SNP) variants miR-126 rs4636297, miR-146a ...
Li, R., Yu, Y., Jaafar, S. O., Baghchi, B., Farsimadan, M., Arabipour, I., Vaziri, H.   +6 more
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Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer [PDF]

BMC Cancer, 2012
MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and ...
Schee Kristina, Boye Kjetil, Abrahamsen Torveig, Fodstad Øystein, Flatmark Kjersti   +4 more
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Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients [PDF]

British Journal of Cancer, 2015
Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC.Seven microRNAs (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429) were quantified in the serum of 180 ...
Xiaodan Meng, Simon A Joosse, Volkmar Müller, Fabian Trillsch, Karin Milde-Langosch, Sven Mahner, Maria Geffken, Klaus Pantel, Heidi Schwarzenbach   +8 more
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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Molecular Cancer, 2020
Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and drug resistance by secreting various ...
Haiyang Zhang, T. Deng, Rui Liu, T. Ning, Haiou Yang, Dongying Liu, Qiumo Zhang, D. Lin, S. Ge, M. Bai, Xinyi Wang, Le Zhang, Hongli Li, Yuchong Yang, Zhi Ji, Hailong Wang, G. Ying, Y. Ba   +17 more
semanticscholar   +1 more source

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

Journal of Hematology & Oncology, 2020
Background Mounting evidence has demonstrated the vital importance of tumor-associated macrophages (TAMs) and exosomes in the formation of the premetastatic niche.
Senlin Zhao, Yushuai Mi, Bingjie Guan, Binbin Zheng, P. Wei, Yanzi Gu, Zhengxiang Zhang, S. Cai, Ye Xu, Xinxiang Li, Xuefeng He, X. Zhong, Guichao Li, Zhi-yu Chen, Dawei Li   +14 more
semanticscholar   +1 more source

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Journal of Nanobiotechnology, 2020
Background5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC.
G. Liang, Yanliang Zhu, D. Ali, Tian Tian, Huantian Xu, Ke Si, Bo Sun, Baoan Chen, Zhongdang Xiao   +8 more
semanticscholar   +1 more source

The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

Molecular Therapy: Nucleic Acids, 2020
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be related to tumor suppression or oncogenic function.
Diana Bautista-Sánchez, Cristian Arriaga-Canon, Abraham Pedroza-Torres, I. A. de la Rosa-Velázquez, R. González-Barrios, Laura Contreras-Espinosa, Rogelio Montiel-Manríquez, C. Castro-Hernández, V. Fragoso-Ontiveros, R. M. Álvarez-Gómez, L. Herrera   +10 more
semanticscholar   +1 more source

miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF [PDF]

Cellular and Molecular Life Sciences, 2014
Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that regulates brain development, synaptogenesis, memory and learning, as well as development of peripheral organs, such as angiogenesis in the heart and postnatal growth and repair of skeletal muscle.
Varendi, Kärt, Kumar, Anmol, Härma, Mari-Anne, Andressoo, Jaan-Olle   +3 more
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miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging [PDF]

Aging Cell, 2010
SummaryAging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically encoded repair systems. To better understand the genetic component of aging, many studies have addressed the gene and protein expression profiles of various aging model systems engaging different ...
Strasser, A., Trost, A., Grubeck-Loebenstein, B., Mück, C., Papak, C., Schreiner, C., Herndler-Brandstetter, D., Tschachler, E., Laschober, G., Lepperdinger, G., Kühnel, H., Grillari, J., Bauer, J.W., Fortschegger, K., Eckhard, L., Micutkova, L., Breitenbach, M., Hackl, M., Mildner, M., Rinnerthaler, M., Scheideler, M., Wieser, M., Sampson, N., Berger, P., Jansen-Dürr, P., Grillari-Voglauer, R., Brunner, S., Trajanoski, Z.   +27 more
openaire   +3 more sources