Results 11 to 20 of about 447,640 (362)
Deciphering miRNAs’ Action through miRNA Editing [PDF]
International Journal of Molecular Sciences, 2019 MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation.
M. Correia de Sousa +4 more
semanticscholar +4 more sources
Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions [PDF]
BioMed Research International, 2014 MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA
Guo, Li +4 more
openaire +2 more sources
Scientific Reports, 2023 In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and periphery, thus orchestrating rhythms throughout the body.
Lidia Giantomasi +6 more
doaj +1 more source
Glial Bmal1 role in mammalian retina daily changes
Scientific Reports, 2022 Visual information processing in the retina requires the rhythmic expression of clock genes. The intrinsic retinal circadian clock is independent of the master clock located in the hypothalamic suprachiasmatic nucleus and emerges from retinal cells ...
Serena Riccitelli +8 more
doaj +1 more source
Nucleic Acids Res., 2021 MicroRNAs (miRNAs) are noncoding RNAs with 18–26 nucleotides; they pair with target mRNAs to regulate gene expression and produce significant changes in various physiological and pathological processes. In recent years, the interaction between miRNAs and
Hsi-Yuan Huang +34 more
semanticscholar +1 more source
Recent Advances in miRNA Delivery Systems
Methods and Protocols, 2021 MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription.
I. Dasgupta, Anushila Chatterjee
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 The NLRP3-mediated pyroptosis, which could be regulated by miRNA-27a, is a key player in the development of depression. Isoliquiritin is a phenolic flavonoid compound that has been demonstrated to suppress NLRP3-mediated pyroptosis.
Yuanjie Li +7 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important posttranscriptional regulators of gene expression. miRNAs production is controlled at multiple levels, including transcriptional and posttranscriptional regulation.
Khalid Otmani, P. Lewalle
semanticscholar +1 more source
miRNA-based biomarkers, therapies, and resistance in Cancer
International Journal on Biological Sciences, 2020 MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer.
Boxue He +10 more
semanticscholar +1 more source
The Risks of miRNA Therapeutics: In a Drug Target Perspective
Drug Design, Development and Therapy, 2021 RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs, were approved by the Food and Drug Administration in 2018 and 2019, respectively.
Song Zhang +3 more
semanticscholar +1 more source