Results 11 to 20 of about 487,200 (353)
miRNAs: Whys and Wherefores of miRNA-Mediated Regulation [PDF]
Current Biology, 2005 MiRNAs are assumed to be important in animal development and physiology, but their specific roles in vivo are still poorly understood. New bioinformatic and genetic studies are setting the stage for unraveling the specific biological functions of miRNAs.
Eric C. Lai
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Cancers, 2021 Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed +2 more
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Diagnostic and Prognostic Circulating MicroRNA in Acute Stroke: A Systematic and Bioinformatic Analysis of Current Evidence [PDF]
Journal of Stroke, 2021 Background and Purpose Stroke is the second leading cause of death and disability worldwide and its diagnosis, and assessment of prognosis, remains challenging. There is a need for improved diagnostic and prognostic biomarkers.
Jorin Bejleri +4 more
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The expression profile of exosomal miRNAs in cervical cancer cells (HeLa) compared to normal cells and evaluating the key genes related to them [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2023 Introduction: Cervical cancer is the fourth most common cancer among women worldwide and is a heterogeneous disease. The exosomal miRNAs could be applied as diagnostic biomarkers and therapeutic targets in cervical cancer. The present study was performed
Marzieh Naderi Boldaji +2 more
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Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions [PDF]
BioMed Research International, 2014 MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA
Hui Zhang +4 more
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Scientific Reports, 2023 In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and periphery, thus orchestrating rhythms throughout the body.
Lidia Giantomasi +6 more
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A Xenotransplant Model of Human Brain Tumors in Wild-Type Mice
iScience, 2020 Summary: The development of adequate model systems to study human malignancies is crucial for basic and preclinical research. Here, we exploit the “immune-privileged” developmental time window to achieve orthotopic xenotransplantation of human brain ...
Nadin Hoffmann +5 more
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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High-throughput sequencing analysis of mirna expression in embryonic chicken breast muscle [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 The embryonic period is a critical period for the development of muscle and adipose tissue in chickens. MicroRNAs (miRNAs) have been shown to play important roles in various biological processes, but little is known about miRNAs in chicken embryos.
Lei ZHANG +3 more
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The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer [PDF]
Frontiers in Oncology, 2015 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and
Xin eQin +4 more
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