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Regulation of miRNA content. Part 1. Editing miRNA. Тailing miRNA
CHILD`S HEALTH, 2022 This scientific review presents the processes of regulation of miRNA content. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka databases.
A.E. Abaturov, V.L. Babуch
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A novel strategy for orthogonal genetic regulation on different RNA targeted loci simultaneously
RNA Biology, 2022 No current RNA-targeted interference tools have been reported to simultaneously up and down-regulate different gene expressions. Here we characterized an RNA-targeted genetic regulatory strategy composed of a flap endonuclease 1 (FEN1) and specific mis ...
Yongjian Guo +9 more
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MiRNAs and miRNA Polymorphisms Modify Drug Response [PDF]
International Journal of Environmental Research and Public Health, 2016 Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level.
Li, Mu-Peng +7 more
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Mechanisms of non-coding RNA-modulated alternative splicing in cancer
RNA Biology, 2022 Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang +6 more
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Nucleic Acids Res., 2013 Although microRNAs (miRNAs), other non-coding RNAs (ncRNAs) (e.g. lncRNAs, pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been implicated in cell-fate determination and in various human diseases, surprisingly little is known about ...
Junhao Li +4 more
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The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer [PDF]
Frontiers in Oncology, 2015 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and
Xin eQin +4 more
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miR-34 – A microRNA Replacement Therapy Is Headed to the Clinic
Frontiers in Genetics, 2012 MicroRNA-34 is a master regulator of tumor suppression. It is downregulated in numerous cancers and inhibits malignant growth by repressing genes involved in various oncogenic signaling pathways.
Andreas G Bader
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Exploring Biomarkers for Alzheimer’s Disease [PDF]
Journal of Clinical and Diagnostic Research, 2016 Alzheimer’s Disease (AD) is one of the most common form of dementia occurring in elderly population worldwide. Currently Aβ42, tau and p-tau in the cerebrospinal fluid is estimated for confirmation of AD. CSF which is being used as the potent source for
Neeti Sharma, Anshika Nikita Singh
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Plant Signaling & Behavior, 2022 Glutathione (GSH) is well known to play a crucial role in imparting resistance against various pathogen invasions. Nevertheless, the role of GSH in regulating miRNA-mediated defense response is yet to be explored.
Riddhi Datta +4 more
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Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma
Clinical Neurology and Neurosurgery, 2017 Meningiomas are among the most common intracranial tumors, accounting for 30% of all tumors of the central nervous system. Recent studies analyzing microRNA (miRNA) profiles and functions in cancer have provided valuable information about the molecular pathogenesis of several tumor types, including glioblastoma multiforme (GBM), hepatocellular ...
Katar, Salim +8 more
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