Results 21 to 30 of about 461,417 (302)

Administration of Insurance Rate Regulatory Laws [PDF]

open access: yes, 1950
microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was
Ernberg, Ingemar   +5 more
core   +3 more sources

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

open access: yesNature Communications, 2017
Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to ...
Olga Barca-Mayo   +5 more
doaj   +1 more source

Representation of an absent space: construction of the United States and New York in 1950s and 1960s Czech travel writing [PDF]

open access: yes, 2015
Early postwar Czech travel writing was mainly concerned with representations of countries from the newly emerging Soviet Bloc and former European colonies in the developing world.
Solic, Mirna
core   +1 more source

DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex

open access: yesFrontiers in Neuroscience, 2018
DGCR8 and DROSHA are the minimal functional core of the Microprocessor complex essential for biogenesis of canonical microRNAs and for the processing of other RNAs. Conditional deletion of Dgcr8 and Drosha in the murine telencephalon indicated that these
Nadin Hoffmann   +4 more
doaj   +1 more source

NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders

open access: yesFrontiers in Bioscience-Elite, 2023
Obese individuals are at high risk for developing type 2 diabetes mellitus, cardiovascular diseases, and nonalcoholic fatty liver disease. The aim of this review was to analyze the scientific literature and databases to reveal the fundamental role of ...
Maria Vulf   +10 more
doaj   +1 more source

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis [PDF]

open access: yes, 2015
MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and miRNA-
Atkin, S. L.   +3 more
core   +1 more source

Glioblastoma and MiRNAs [PDF]

open access: yesCancers, 2021
Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed   +2 more
openaire   +3 more sources

The importance of training in contemporary organizations

open access: yesMенаџмент у хотелијерству и туризму, 2019
This paper describes the concepts of training and career development for employees, level of knowledge of workers, the profit that some companies had from continuous training, and the way in which an organizational psychologist, with the support of ...
Ana Slavković, Vukan Slavković
doaj   +1 more source

MicroRNA-6744-5p promotes anoikis in breast cancer and directly targets NAT1 enzyme

open access: yesCancer Biology & Medicine, 2020
Objective: Anoikis is apoptosis that is induced when cells detach from the extracellular matrix and neighboring cells. As anoikis serves as a regulatory barrier, cancer cells often acquire resistance towards anoikis during tumorigenesis to become ...
Sharan Malagobadan   +2 more
doaj   +1 more source

Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort

open access: yesEpigenetics, 2022
Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications.
Caitlin G. Howe   +8 more
doaj   +1 more source

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