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MITF: A Stream Flowing for Pigment Cells [PDF]

Pigment Cell & Melanoma Research, 2000
Microphthalmia‐associated t ranscription f actor (MITF) is a transcription factor with a basic‐helix‐loop‐helix‐leucine zipper (bHLHZip) structure. Mutations of the MITF gene cause a variety of phenotypes, most notably in pigmented cells, in several species. In humans, haploinsufficiency of MITF causes Waardenburg syndrome type 2, while a
Masayoshi Tachibana
exaly   +3 more sources

Frequent mutations in the MITF pathway in melanoma [PDF]

Pigment Cell and Melanoma Research, 2009
SummaryMicrophthalmia‐associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia. To determine whether MITF is somatically mutated in melanoma, we compared the sequence of MITF from primary and metastatic lesions to patient‐matched normal DNA.
John Wunderlich, Stacie K Loftus, Todd D Prickett   +2 more
exaly   +3 more sources

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways

Food Science and Human Wellness, 2023
Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood. The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 ...
Zhiyun Du
exaly   +3 more sources

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Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform

Gene, 2005
The deafness-pigmentary disorder Waardenburg Syndrome Type 2 is caused by mutations in the human Microphthalmia-associated transcription factor (MITF) gene. Multiple related deafness-pigmentary disorders result from mutations in genes that regulate MITF expression or its activity.
Christine L, Hershey, David E, Fisher
openaire   +2 more sources

Effect of MITF on mast cell differentiation

Molecular Immunology, 2002
The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor and encoded by the mi locus of mice. Double gene dose of mutant allele at the mi locus results the decrease of mast cells and phenotypic abnormalities of mast cells. Various mutations have been reported at the mi locus.
Yukihiko, Kitamura, Eiichi, Morii, Tomoko, Jippo, Akihiko, Ito   +3 more
openaire   +2 more sources

MITF, the Janus Transcription Factor of Melanoma

Future Oncology, 2013
Current models of melanoma propose that transition from the proliferative to the invasive stages of tumor development involves a dynamic and reversible switch in cell phenotype. The almost mutually exclusive proliferative and invasive phenotypes are defined by distinct gene expression signatures, which are themselves controlled by the level of ...
Dana, Koludrovic, Irwin, Davidson
openaire   +2 more sources

Mitf Is Expressed in Osteoclast Progenitors in Vitro

Experimental Cell Research, 2000
Microphthalmia mutant (mi/mi) mice reveal defects in osteoclastogenesis and exhibit osteopetrosis. However, there have been no studies to test the importance of Mitf in in vitro osteoclastogenesis using the cells derived from mi/mi mice. Therefore, we investigated in vitro osteoclastogenesis using the cells derived from mi/mi mice. We cocultured spleen
N, Kawaguchi, M, Noda
openaire   +2 more sources

Regulation of Mast Cell Phenotype by MITF

International Archives of Allergy and Immunology, 2002
The development of mast cells is controlled through the cooperative effects of growth factors and nuclear transcription factors. The signals generated by the binding of stem cell factor (SCF) to c-<i>kit</i> receptor tyrosine kinase (KIT) are essential for their development and survival.
Yukihiko, Kitamura, Eiichi, Morii, Tomoko, Jippo, Akihiko, Ito   +3 more
openaire   +2 more sources

MITF Positivity in Atypical Fibroxanthoma

The American Journal of Dermatopathology, 2014
Microphthalmia transcription factor (MITF) is an established melanocytic marker originally credited with a high degree of specificity. We report a series of 11 atypical fibroxanthoma (AFX) from 2 laboratories showing positive MITF staining. Although there are multiple case reports illustrating MITF staining in a range of tumors, aberrant staining in ...
Ben, Tallon, Trevor W, Beer, Trevor M, Beer   +2 more
openaire   +2 more sources

MITF Pathway-Activated Cutaneous Neoplasms

Advances in Anatomic Pathology
Over the past few years, several fusion genes have been reported in dermal-based tumors, resulting in the activation of the microphthalmia (MITF) signalling pathway and a melanocytic phenotype by immunohistochemistry. The best-studied example of these tumors is clear cell sarcoma, which rarely may present as a primary dermal tumor.
Michael, Michal, Steven D, Billings, Thomas, Brenn   +2 more
openaire   +2 more sources