Results 151 to 160 of about 16,506 (196)

α-Mangostin, a safe and natural product as a candidate skin-whitening agent. [PDF]

Sci Rep
Li X, Zhu X, Wang B, Sun J, Xia Y.
europepmc   +1 more source

MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma. [PDF]

Cell Rep
Dias D, Oliveira E, Martí-Díaz R, Andrews S, Chocarro-Calvo A, Bellini A, Mosteo L, García YV, Chauhan J, Li L, García-Martinez JM, Rodriguez-López JN, Maria-Engler SS, Kenny C, Martínez-Useros J, García-Jiménez C, Sanchez-Del-Campo L, Louphrasitthiphol P, Goding CR.   +18 more
europepmc   +1 more source

TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis

Sharma N, Tanwar A, Zheng C, Ambudkar I, Motiani RK.   +4 more
europepmc   +1 more source

Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage

Brombin A, MacMaster S, Travnickova J, Wyatt C, Brunsdon H, Ramsey E, Vu HN, Steingrimsson E, Kenny C, Chandra T, Patton EE.   +10 more
europepmc   +1 more source

Frequent mutations in the MITF pathway in melanoma [PDF]

Pigment Cell and Melanoma Research, 2009
SummaryMicrophthalmia‐associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia. To determine whether MITF is somatically mutated in melanoma, we compared the sequence of MITF from primary and metastatic lesions to patient‐matched normal DNA.
William Pavan, Stacie Loftus, Boris Bastian   +2 more
exaly   +3 more sources

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways

Food Science and Human Wellness, 2023
Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood. The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 ...
Zhiyun Du
exaly   +3 more sources

MITF: A Stream Flowing for Pigment Cells [PDF]

Pigment Cell & Melanoma Research, 2000
Microphthalmia‐associated t ranscription f actor (MITF) is a transcription factor with a basic‐helix‐loop‐helix‐leucine zipper (bHLHZip) structure. Mutations of the MITF gene cause a variety of phenotypes, most notably in pigmented cells, in several species. In humans, haploinsufficiency of MITF causes Waardenburg syndrome type 2, while a
exaly   +3 more sources

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Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform

Gene, 2005
The deafness-pigmentary disorder Waardenburg Syndrome Type 2 is caused by mutations in the human Microphthalmia-associated transcription factor (MITF) gene. Multiple related deafness-pigmentary disorders result from mutations in genes that regulate MITF expression or its activity.
Christine L, Hershey, David E, Fisher
openaire   +2 more sources

MITF, the Janus Transcription Factor of Melanoma

Future Oncology, 2013
Current models of melanoma propose that transition from the proliferative to the invasive stages of tumor development involves a dynamic and reversible switch in cell phenotype. The almost mutually exclusive proliferative and invasive phenotypes are defined by distinct gene expression signatures, which are themselves controlled by the level of ...
Koludrovic, Dana, Davidson, Irwin
openaire   +2 more sources