Results 161 to 170 of about 16,506 (196)
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Mitf Is Expressed in Osteoclast Progenitors in Vitro
Experimental Cell Research, 2000Microphthalmia mutant (mi/mi) mice reveal defects in osteoclastogenesis and exhibit osteopetrosis. However, there have been no studies to test the importance of Mitf in in vitro osteoclastogenesis using the cells derived from mi/mi mice. Therefore, we investigated in vitro osteoclastogenesis using the cells derived from mi/mi mice. We cocultured spleen
N, Kawaguchi, M, Noda
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Effect of MITF on mast cell differentiation
Molecular Immunology, 2002The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor and encoded by the mi locus of mice. Double gene dose of mutant allele at the mi locus results the decrease of mast cells and phenotypic abnormalities of mast cells. Various mutations have been reported at the mi locus.
Yukihiko, Kitamura +3 more
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Regulation of Mast Cell Phenotype by MITF
International Archives of Allergy and Immunology, 2002The development of mast cells is controlled through the cooperative effects of growth factors and nuclear transcription factors. The signals generated by the binding of stem cell factor (SCF) to c-<i>kit</i> receptor tyrosine kinase (KIT) are essential for their development and survival.
Yukihiko, Kitamura +3 more
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MITF Positivity in Atypical Fibroxanthoma
The American Journal of Dermatopathology, 2014Microphthalmia transcription factor (MITF) is an established melanocytic marker originally credited with a high degree of specificity. We report a series of 11 atypical fibroxanthoma (AFX) from 2 laboratories showing positive MITF staining. Although there are multiple case reports illustrating MITF staining in a range of tumors, aberrant staining in ...
Ben, Tallon +2 more
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Pigment Cell Research, 2004
Microphthalmia transcription factor (MITF) positively regulates transcription of differentiation‐related genes in several cell lineages, including melanocytes. Recent data also indicate a new important role for MITF as a factor that appears to be required for survival of melanoma cells, suggesting a possibility that abrogation of MITF function in ...
Jiri, Vachtenheim, Blanka, Drdová
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Microphthalmia transcription factor (MITF) positively regulates transcription of differentiation‐related genes in several cell lineages, including melanocytes. Recent data also indicate a new important role for MITF as a factor that appears to be required for survival of melanoma cells, suggesting a possibility that abrogation of MITF function in ...
Jiri, Vachtenheim, Blanka, Drdová
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MITF Pathway-Activated Cutaneous Neoplasms
Advances in Anatomic PathologyOver the past few years, several fusion genes have been reported in dermal-based tumors, resulting in the activation of the microphthalmia (MITF) signalling pathway and a melanocytic phenotype by immunohistochemistry. The best-studied example of these tumors is clear cell sarcoma, which rarely may present as a primary dermal tumor.
Michael, Michal +2 more
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A picture of Mitf in melanoma immortality
Oncogene, 2011The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase ...
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MITF pathway mutations in melanoma
Pigment Cell & Melanoma Research, 2009Satoru, Yokoyama +2 more
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MITF Positivity in Atypical Fibroxanthoma
The American Journal of Dermatopathology, 2016Ben, Tallon, Trevor W, Beer
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