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Mitochondrial Dysfunction in Gliomas
Seminars in Pediatric Neurology, 2013Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate ...
Christos D, Katsetos +2 more
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Mitochondrial Dysfunction in Neurodegeneration
Journal of Bioenergetics and Biomembranes, 1997Numerous toxins are known to interfere with mitochondrial respiratory chain functions. Use has been made of these in the development of pesticides and herbicides, and accidental use in man has led to the development of animal models for human disease. The propensity for mitochondrial toxins to induce neuronal cell death may well reflect not only their ...
J M, Cooper, A H, Schapira
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Mitochondrial Dysfunction in Migraine
Seminars in Pediatric Neurology, 2013Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and
William R, Yorns, H Huntley, Hardison
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Mitochondrial dysfunction in obesity
Life Sciences, 2018Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction.
Aline Haas, de Mello +3 more
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Toxin-induced mitochondrial dysfunction
2002Publisher Summary This chapter reviews the mode of action of several well-characterized mitochondrial toxins, and discusses their effects in contrast with mechanisms of cell death in various degenerative disorders. The majority of known toxins specifically target components of mitochondrial metabolic pathways.
Susan E, Browne, M Flint, Beal
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Mitochondrial dysfunction in Parkinson's disease
Biochemical Society Symposia, 1999The cause of Parkinson's disease (PD) is unknown, but reduced activity of complex I of the electron-transport chain has been implicated in the pathogenesis of both mitochondrial permeability transition pore-induced Parkinsonism and idiopathic PD. We developed a novel model of PD in which chronic, systemic infusion of rotenone, a complex-I inhibitor ...
J T, Greenamyre +3 more
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Movement disorders and mitochondrial dysfunction
Current Opinion in Neurology, 1997Primary defects of mitochondrial DNA leading to respiratory chain dysfunction have been described in association with dystonia, chorea and parkinsonism. Myoclonus remains the commonest movement disorder associated with such defects. The genetic basis of Leigh's syndrome, which is frequently associated with movement disorders, may be mitochondrial or ...
M G, Hanna, K P, Bhatia
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Mitochondrial Dysfunction in Huntington’s Disease
2018Mitochondrial dysfunction has been described as an early pathological mechanism delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a polyglutamine-expansion disorder that largely affects the striatum and the cerebral cortex. Over the years, mitochondria roles in eukaryotic cells (e.g. in neurons) have largely diverged
Catarina, Carmo +3 more
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Mitochondrial dysfunction in bipolar disorder
2010Phosphorus magnetic resonance spectroscopic studies in bipolar disorder revealed altered brain energy metabolism resembling that of chronic progressive external ophthalmoplegia (CPEO). Mood disorder is one characteristic symptom in several families of CPEO caused by mutations of three genes, ANT1, Twinkle, and POLG.
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