Results 271 to 280 of about 49,263 (303)

Function and regulation of the divisome for mitochondrial fission

Nature, 2021
Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative fusion and fission events of the organelles. It is now appreciated that mitochondrial fission also represents an end-point event in a signalling axis that allows cells to sense and respond to external cues.
Felix Kraus, Krishnendu Roy, Thomas J Pucadyil   +2 more
exaly   +5 more sources

Mitochondrial fission and fusion

Biochemical Society Transactions, 2016
Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes.
Hakjoo, Lee, Yisang, Yoon
openaire   +2 more sources

Mitochondrial fission in apoptosis

Nature Reviews Molecular Cell Biology, 2005
Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.
Richard J, Youle, Mariusz, Karbowski
openaire   +2 more sources

Mitochondrial fission fueled by fasting

Science Signaling, 2023
Fasting activates mTORC2 to stimulate mitochondrial fission and support mitochondrial respiration.
openaire   +2 more sources

Mitochondrial fission and fusion

Biochemistry (Moscow), 2015
Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev, I O, Mazunin, E N, Vinogradova, P A, Kamenski   +3 more
openaire   +2 more sources

Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast

The FEBS Journal, 2021
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong, Mengdan Zhu, Fan Zheng, Chuanhai Fu   +3 more
openaire   +2 more sources

A Lethal Defect of Mitochondrial and Peroxisomal Fission

New England Journal of Medicine, 2007
We report on a newborn girl with microcephaly, abnormal brain development, optic atrophy and hypoplasia, persistent lactic acidemia, and a mildly elevated plasma concentration of very-long-chain fatty acids. We found a defect of the fission of both mitochondria and peroxisomes, as well as a heterozygous, dominant-negative mutation in the dynamin-like ...
Waterham, Hans R., Koster, Janet, van Roermund, Carlo W. T., Mooyer, Petra A. W., Wanders, Ronald J. A., Leonard, James V.   +5 more
openaire   +2 more sources

Reciprocal Regulation of Mitochondrial Fission and Fusion

Trends in Biochemical Sciences, 2020
The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control.
Rasha Sabouny, Timothy E. Shutt
openaire   +2 more sources

Mitochondrial Fission Mediates Endothelial Inflammation

Hypertension, 2020
Endothelial inflammation and mitochondrial dysfunction have been implicated in cardiovascular diseases, yet, a unifying mechanism tying them together remains limited. Mitochondrial dysfunction is frequently associated with mitochondrial fission/fragmentation mediated by the GTPase Drp1 (dynamin-related protein 1).
Steven J, Forrester, Kyle J, Preston, Hannah A, Cooper, Michael J, Boyer, Kathleen M, Escoto, Anthony J, Poltronetti, Katherine J, Elliott, Ryohei, Kuroda, Masashi, Miyao, Hiromi, Sesaki, Tomoko, Akiyama, Yayoi, Kimura, Victor, Rizzo, Rosario, Scalia, Satoru, Eguchi   +14 more
openaire   +2 more sources

Mitochondrial fusion and fission in the control of apoptosis

Trends in Cell Biology, 2005
Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini, Thomas, Roumier, Guido, Kroemer   +2 more
openaire   +2 more sources