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Drp1-dependent mitochondrial fission in cardiovascular disease
Acta Pharmacologica Sinica, 2020Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy ...
Jia-Yu, Jin +4 more
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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases
New England Journal of Medicine, 2013Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
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Mitochondrial fission in apoptosis, neurodegeneration and aging
Current Opinion in Cell Biology, 2003A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and is thought to play a causal role in their biology. Unfortunately, the molecular basis underlying this detrimental loss in mitochondrial function remains mysterious. Interestingly, mitochondria undergo frequent fission and fusion.
Ella, Bossy-Wetzel +4 more
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Mitochondrial fission and fusion machineries
2004Mitochondria are dynamic organelles, often fusing and dividing in response to changes in the cellular environment, during cell division and differentiation and under many other circumstances that affect mitochondrial function. Mitochondrial division is also an integral part of the apoptotic pathway in mammalian cells.
Lorena Griparic +2 more
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Function and regulation of the divisome for mitochondrial fission
Nature, 2021Felix Kraus +2 more
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Molecular Cell, 2021Che-Chia Hsu, Guihua Wang, Zhen Cai
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