Results 281 to 290 of about 49,263 (303)

Mitochondrial fission in apoptosis, neurodegeneration and aging

Current Opinion in Cell Biology, 2003
A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and is thought to play a causal role in their biology. Unfortunately, the molecular basis underlying this detrimental loss in mitochondrial function remains mysterious. Interestingly, mitochondria undergo frequent fission and fusion.
Ella, Bossy-Wetzel, Mark J, Barsoum, Adam, Godzik, Robert, Schwarzenbacher, Stuart A, Lipton   +4 more
openaire   +2 more sources

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2013
Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
openaire   +2 more sources

Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2014
no ...
Sanchis-Gomar, F, Derbré, Frédéric
openaire   +4 more sources

Mitochondrial and peroxisomal fission in cortical neurogenesis

The International Journal of Biochemistry & Cell Biology
The human brain is unique in its cellular diversity, intricate cytoarchitecture, function, and complex metabolic and bioenergetic demands, for which mitochondria and peroxisomes are essential. Mitochondria are multifunctional organelles that coordinate various signaling pathways central to neurogenesis.
Gabriella L. Robertson, Caroline Bodnya, Vivian Gama   +2 more
openaire   +2 more sources

Recent insights into the control of mitochondrial fission

Biochemical Society Transactions
Mitochondria are the powerhouse of the cell. They undergo fission and fusion to maintain cellular homeostasis. In this review, we explore the intricate regulation of mitochondrial fission at various levels, including the protein level, the post-translational modification level, and the organelle level.
Jiajia He, Ke Liu, Chuanhai Fu
openaire   +2 more sources

Sharpening the Scissors: Mitochondrial Fission With Aid

Cell Biochemistry and Biophysics, 2004
Over the past 5 yr, research in mitochondrial morphology has advanced rapidly, mainly as a result of the identification of protein factors involved in mitochondrial fission and fusion. The pathological relevance of these processes becomes clear as apoptotic cell death evidently involves mitochondrial fission and fusion machinery.
openaire   +2 more sources

The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy

Molecular Cell, 2023
Yuta Ogasawara, Tetsu Saigusa, Kazuho Ikeda   +2 more
exaly  

The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy

International Journal of Molecular Sciences, 2023
Nir Qvit, Qvit Nir
exaly  

Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1

Cancer Communications, 2022
Zifeng Zhao, Ning Liang, Peng Yuan
exaly  

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

Molecular Cell, 2021
Zhen Cai, Bo-Syong Pan, Haiwei Gu
exaly