Results 241 to 250 of about 57,770 (292)

Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting. [PDF]

Front Oncol
Huang W, Sun W, Yang Z, Li Y, Wang Z.
europepmc   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Mitophagy and Ubiquitination Coordinate Context-Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion. [PDF]

Adv Sci (Weinh)
Mao BH, Su BK, Wang YJ, Tu TY.
europepmc   +1 more source

Comparative Genomics Provide Insights Into Karyotype Evolution in Vespertilionid Bats (Vespertilionidae, Chiroptera)

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Studies elucidating the molecular basis and evolutionary consequences of karyotypic changes in mammals remain scarce. Here, we investigate chromosomal evolution by focusing on two contrasting lineages within the family Vespertilionidae (Chiroptera): the karyotypically variable tribe Pipistrellini and the highly conserved genus Myotis ...
Linjing Lan, Xin Zhang, Jinjin Xie, Xiaohui Lin, Xihong Hong, Wenhui Nie, Jinhuan Wang, Weiting Su, Fengtang Yang, Guimei He, Xiuguang Mao   +10 more
wiley   +1 more source

Mitochondrial-targeted therapy for osteoarthritis: Challenges and opportunities from basic research to clinical translation. [PDF]

Front Immunol
Zhang SO, Gu ZQ, Ruan J, Zhang J, Chen H.   +4 more
europepmc   +1 more source

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source

Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells. [PDF]

J Ovarian Res
Cao Y, Tong X, Hu W, Wang Y, Lu W, Chen Y, You J, Feng Y, Song Q.   +8 more
europepmc   +1 more source

Autophagy‐Independent Function of ATG‐18 Is Essential for Gonadal Longevity in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 4, April 2026.
Neuronal and intestinal ATG‐18 promote longevity conferred by germline removal in C. elegans via non‐autophagic functions. In the intestine, ATG‐18 regulates lifespan through its interaction with the gluconeogenic enzyme PCK‐2. ABSTRACT Autophagy, a highly conserved cellular degradation process, plays essential roles in various physiological processes ...
Tatsuya Shioda, Ittetsu Takahashi, Makoto Horikawa, Taiichi Osumi, Takayuki Shima, Akiyo Yamauchi, Kayo Nakamura, Taeko Sasaki, Tatsuya Kaminishi, Harunori Yoshikawa, Miyuki Sato, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura   +13 more
wiley   +1 more source

Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging. [PDF]

Aging Adv
Nivedya C, Venkhatesh P, Rodriguez BI, Le H, Afolabi J, Marshall A, Neikirk K, Masenga SK, Aftab M, Kazma LJ, Katti P, Hinton A.   +11 more
europepmc   +1 more source

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respond in skeletal muscle to support this remarkable resilience.
Audrey Bergouignan, John Noone, Charlotte Brun, Laura Cussonneau, Alexandre Geffroy, Cecile Coudy‐Gandilhon, Isabelle Chery, Alina Lynn Evans, Jon Martin Arnemo, Jonas Kindberg, Guillemette Gauquelin‐Koch, Donal O'Gorman, Etienne Lefai, Fabrice Bertile   +13 more
wiley   +1 more source