Results 71 to 80 of about 34,022 (144)

RNA-binding protein RCAN1.1L modulates ATF2 mRNA stability to promote mitochondrial fission in acute ischemic stroke

Cell Death and Disease
Regulator of calcineurin 1 (RCAN1) is an RNA-binding protein with diverse functions, the regulatory mechanisms underlying mitochondrial function in ischemic neuronal injury remain only partially understood.
Yanbin Ji, Xiaochun Ma, Liyuan Wang, Fangfei Liu, Yao Tang, Xiaxin Yang, Zexin Zhan, Shuangwu Liu, Juan Zhao, Tan Wang, Fuchen Liu, Dexin Yu, Yuguo Chen, Yan Yun, Xiulian Sun   +14 more
doaj   +1 more source

Vimar Is a Novel Regulator of Mitochondrial Fission through Miro.

PLoS Genetics, 2016
As fundamental processes in mitochondrial dynamics, mitochondrial fusion, fission and transport are regulated by several core components, including Miro.
Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu   +5 more
doaj   +1 more source

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. [PDF]

Front Immunol, 2021
Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P.   +11 more
europepmc   +1 more source

The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy. [PDF]

FEBS Open Bio, 2021
Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Wang J, Xing HR.   +7 more
europepmc   +1 more source

Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission

iScience
Summary: Mitochondrial dynamics is a process that balances fusion and fission events, the latter providing a mechanism for segregating dysfunctional mitochondria. Fission is controlled by the mitochondrial membrane potential (ΔΨm), optic atrophy 1 (OPA1)
Charlène Lhuissier, Valérie Desquiret-Dumas, Anaïs Girona, Jennifer Alban, Justine Faure, Julien Cassereau, Philippe Codron, Guy Lenaers, Olivier R. Baris, Naïg Gueguen, Arnaud Chevrollier   +10 more
doaj   +1 more source

Loss of dynamin 1-like protein impairs mitochondrial function and self-renewal, and activates the integrated stress response in human embryonic stem cells

Frontiers in Genetics
Dynamin 1-like protein (DNM1L/DRP1) is a crucial regulator of mitochondrial fission in cells and pathogenic mutations in DNM1L are linked to developmental and metabolic disorders in humans.
Artur Cieslar-Pobuda, Artur Cieslar-Pobuda, Safak Caglayan, Safak Caglayan   +3 more
doaj   +1 more source

Alternative splicing of Mff regulates AMPK-mediated phosphorylation, mitochondrial fission and antiviral response

Pharmacological Research
Mitochondrial morphology and function change dynamically in response to intracellular signaling and the surrounding environment. The mitochondrial fission factor Mff, which localizes to the outer mitochondrial membrane, mediates not only mitochondrial ...
Yuki Hanada, Risa Maeda, Takaya Ishihara, Masaki Nakahashi, Yuichi Matsushima, Emi Ogasawara, Toshihiko Oka, Naotada Ishihara   +7 more
doaj   +1 more source

EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat

Journal of Lipid Research
Mitochondria are fundamental to energy homeostasis and undergo dynamic changes in brown and beige fat. Mitochondrial dysfunctions impair thermogenic capacity and cause obesity-associated metabolic diseases.
Sona Rajakumari, Soumya Jaya Divakaran
doaj   +1 more source

A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission.

PLoS Computational Biology
Mitochondrial hyperfission in response to cellular insult is associated with reduced energy production and programmed cell death. Thus, there is a critical need to understand the molecular mechanisms coordinating and regulating the complex process of ...
Anna K Leinheiser, Colleen C Mitchell, Ethan Rooke, Stefan Strack, Chad E Grueter   +4 more
doaj   +1 more source

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy. [PDF]

Int J Biol Sci
Wang J, Zhuang H, Jia L, He X, Zheng S, Ji K, Xie K, Ying T, Zhang Y, Li C, Chang X.   +10 more
europepmc   +1 more source