Results 71 to 80 of about 34,614 (273)

KLF6 aggravates myocardial fibrosis by promoting mitochondrial division

Pakistan Journal of Pharmaceutical Sciences
The dysregulation of mitochondrial dynamics in cardiac fibroblasts (CFs) is closely linked to myocardial fibrosis, which can induce cardiac dysfunction and even lead to heart failure.
Tingting Zhang, Hongyao Ge, Qiuhang Song, Gaoshan Yang, Aiying Li   +4 more
doaj   +1 more source

C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage

Frontiers in Pharmacology, 2019
Mitochondrial dysfunction is a predominant risk factor in ischemic heart disease, in which the imbalance of mitochondrial fusion and fission deteriorates mitochondrial function and might lead to cardiomyocyte death.
Jinchao Gao, Lidong Zhao, Jinfeng Wang, Lihang Zhang, Dandan Zhou, Jinlong Qu, Hao Wang, Ming Yin, Jiang Hong, Wenjuan Zhao   +9 more
doaj   +1 more source

Restriction of trophic factors and nutrients induces PARKIN expression [PDF]

, 2011
Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress ...
Klinkenberg, Michael, Auburger, Georg, S. Gispert, Braun, Isabelle, M. Klinkenberg, Dominguez Bautista, Jorge Antolio, M. Jendrach, Gispert, Suzana, G. Auburger, J. A. Dominguez-Bautista, I. Braun, Jendrach, Marina   +11 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Frontiers in Physiology, 2020
Hyperglycemia-induced mitochondrial dysfunction plays a key role in the pathogenesis of diabetic cardiomyopathy. Injured mitochondrial segments are separated by mitochondrial fission and eliminated by autophagic sequestration and subsequent degradation ...
Satoru Kobayashi, Fengyi Zhao, Ziying Zhang, Tamayo Kobayashi, Yuan Huang, Bingyin Shi, Weihua Wu, Qiangrong Liang   +7 more
doaj   +1 more source

Mitochondrial fusion‐ and fission‐related protein expression in the regulation of skeletal muscle mass

Physiological Reports, 2022
Mitochondria in the skeletal muscle are essential for maintaining metabolic plasticity and function. Mitochondrial quality control encompasses the dynamics of the biogenesis and remodeling of mitochondria, characterized by the constant fission and fusion
Daiki Nakano, Shuichi Machida
doaj   +1 more source

Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles [PDF]

, 2014
SummaryMitochondria are dynamic organelles that change their morphology by active fusion and fission in response to cellular signaling and differentiation [1, 2].
Kawano, Natsuko, Shitara, Hiroshi, Ishihara, Takaya, Tsukamoto, Satoshi, Yokota, Sadaki, Nomura, Masatoshi, Udagawa, Osamu, Matsunaga, Yui, Ishihara, Naotada, Mihara, Katsuyoshi, Mizushima, Noboru, Maeda, Maki, Miyado, Kenji   +12 more
core   +1 more source

Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe [PDF]

Nucleic Acids Research, 2011
We have characterized the mitochondrial transcription factor (Mtf1) and RNA polymerase (Rpo41) of Schizosaccharomyces pombe. Deletion mutants show Mtf1 or Rpo41 to be essential for cell growth, cell morphology and mitochondrial membrane potential. Overexpression of Mtf1 and Rpo41 can induce mitochondrial transcription.
Jiang, Hengyi, Sun, Wenxia, Wang, Zhe, Zhang, Jing, Chen, Dongrong, Murchie, Alastair I. H.   +5 more
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses

Scientific Reports, 2019
The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration.
Alexander Kreymerman, David N. Buickians, Michael M. Nahmou, Tammy Tran, Joana Galvao, Yan Wang, Nicholas Sun, Leah Bazik, Star K. Huynh, In-Jae Cho, Tomasz Boczek, Kun-Che Chang, Noelia J. Kunzevitzky, Jeffrey L. Goldberg   +13 more
doaj   +1 more source