Results 51 to 60 of about 34,022 (144)

Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy

Frontiers in Pharmacology, 2020
Myocardial infarction is the leading cause of morbidity and mortality worldwide. Although myocardial reperfusion after ischemia (I/R) is an effective method to save ischemic myocardium, it can cause adverse reactions, including increased oxidative stress
Tzu-Lin Lee, Ming-Hsueh Lee, Ming-Hsueh Lee, Yu-Chen Chen, Yi-Chieh Lee, Tsai-Chun Lai, Hugo You-Hsien Lin, Lee-Fen Hsu, Lee-Fen Hsu, Hsin-Ching Sung, Hsin-Ching Sung, Chiang-Wen Lee, Chiang-Wen Lee, Chiang-Wen Lee, Yuh-Lien Chen   +14 more
doaj   +1 more source

Targeting and Function of the Mitochondrial Fission Factor GDAP1 Are Dependent on Its Tail-Anchor

PLoS ONE, 2009
PLoS ONE, 4 (4)
Wagner, Konstanze M., Rüegg, Marcel, Niemann, Axel, Suter, Ueli   +3 more
openaire   +6 more sources

Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe [PDF]

Nucleic Acids Research, 2011
We have characterized the mitochondrial transcription factor (Mtf1) and RNA polymerase (Rpo41) of Schizosaccharomyces pombe. Deletion mutants show Mtf1 or Rpo41 to be essential for cell growth, cell morphology and mitochondrial membrane potential. Overexpression of Mtf1 and Rpo41 can induce mitochondrial transcription.
Jiang, Hengyi, Sun, Wenxia, Wang, Zhe, Zhang, Jing, Chen, Dongrong, Murchie, Alastair I. H.   +5 more
openaire   +2 more sources

Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Frontiers in Physiology, 2020
Hyperglycemia-induced mitochondrial dysfunction plays a key role in the pathogenesis of diabetic cardiomyopathy. Injured mitochondrial segments are separated by mitochondrial fission and eliminated by autophagic sequestration and subsequent degradation ...
Satoru Kobayashi, Fengyi Zhao, Ziying Zhang, Tamayo Kobayashi, Yuan Huang, Bingyin Shi, Weihua Wu, Qiangrong Liang   +7 more
doaj   +1 more source

Mitochondrial fusion‐ and fission‐related protein expression in the regulation of skeletal muscle mass

Physiological Reports, 2022
Mitochondria in the skeletal muscle are essential for maintaining metabolic plasticity and function. Mitochondrial quality control encompasses the dynamics of the biogenesis and remodeling of mitochondria, characterized by the constant fission and fusion
Daiki Nakano, Shuichi Machida
doaj   +1 more source

MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses

Scientific Reports, 2019
The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration.
Alexander Kreymerman, David N. Buickians, Michael M. Nahmou, Tammy Tran, Joana Galvao, Yan Wang, Nicholas Sun, Leah Bazik, Star K. Huynh, In-Jae Cho, Tomasz Boczek, Kun-Che Chang, Noelia J. Kunzevitzky, Jeffrey L. Goldberg   +13 more
doaj   +1 more source

Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. [PDF]

PLoS ONE, 2017
The majority of transplanted kidneys are procured from deceased donors which all require exposure to cold storage (CS) for successful transplantation.
Nirmala Parajuli, Stephen Shrum, Julia Tobacyk, Alex Harb, John M Arthur, Lee Ann MacMillan-Crow   +5 more
doaj   +1 more source

NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy

Cellular Physiology and Biochemistry, 2018
Background/Aims: Disrupted mitochondrial dynamics, including excessive mitochondrial fission and mitophagy arrest, has been identified as a pathogenic factor in diabetic nephropathy (DN), although the upstream regulatory signal for mitochondrial fission ...
Junqin Sheng, Hongyan Li, Qin Dai, Chang Lu, Min Xu, Jisheng Zhang, Jianxun Feng   +6 more
doaj   +1 more source

Mitochondrial fission during mitophagy requires both inner and outer mitofissins

EMBO Reports
Mitophagy maintains mitochondrial homeostasis through the selective degradation of damaged or excess mitochondria. Recently, we identified mitofissin/Atg44, a mitochondrial intermembrane space-resident fission factor, which directly acts on lipid ...
Kentaro Furukawa, Tatsuro Maruyama, Yuji Sakai, Shun-ichi Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Nobuo N Noda, Tomotake Kanki   +7 more
doaj   +1 more source

Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission

Open Medicine, 2023
Mitochondrial dysfunction and oxidative stress are considered to be two main drivers of diabetic myocardial ischemia-reperfusion injury (DM + MIRI). Nuclear factor-erythroid 2-related factor 2 (Nrf2) and Dynamin-related protein 1 (Drp1) play central ...
Wang Xiao-Li, Zhu Qian-Qian, Simayi Alimujiang, Xu Gui-Ping   +3 more
doaj   +1 more source