Results 61 to 70 of about 34,022 (144)

TRAF3: A novel regulator of mitochondrial physiology and metabolic pathways in B lymphocytes

Frontiers in Oncology, 2023
Mitochondria, the organelle critical for cell survival and metabolism, are exploited by cancer cells and provide an important therapeutic target in cancers. Mitochondria dynamically undergo fission and fusion to maintain their diverse functions. Proteins
Jaeyong Jung, Jaeyong Jung, Samantha Gokhale, Samantha Gokhale, Ping Xie, Ping Xie   +5 more
doaj   +1 more source

A role for Fis1 in dendritic development

Scientific Reports
Mitochondrial ATP production and calcium handling are critical for metabolic regulation and neurotransmission. Thus, the formation and maintenance of the mitochondrial network is a critical component of neuronal health. Cortical pyramidal neurons contain
Klaudia Strucinska, Parker Kneis, Travis Pennington, Katarzyna Cizio, Patrycja Szybowska, Abigail Morgan, Joshua Weertman, Tommy L. Lewis   +7 more
doaj   +1 more source

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts [PDF]

Cell Metabolism, 2015
How mitochondrial dynamism (fission and fusion) affects mitochondrial quality control is unclear. We uncovered distinct effects on mitophagy of inhibiting Drp1-mediated mitochondrial fission versus mitofusin-mediated mitochondrial fusion. Conditional cardiomyocyte-specific Drp1 ablation evoked mitochondrial enlargement, lethal dilated cardiomyopathy ...
Song M, Mihara K, Chen Y, SCORRANO, LUCA, Dorn GW 2nd   +4 more
openaire   +3 more sources

MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity

Nature Communications, 2020
Mitochondrial antiviral signalling protein (MAVS) is an adaptor of RIG-I like receptor. Here the authors show that mitochondrial fission factor (Mff) is required for clustering of MAVS on the outer mitochondrial membrane during antiviral response.
Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura   +8 more
doaj   +1 more source

Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1

Neurobiology of Disease, 2006
Dorsal root ganglia (DRG) neurons degenerate in diabetic neuropathy (DN) and exhibit mitochondrial damage. We studied mitochondria of cultured DRG neurons exposed to high glucose as an in vitro model of DN.
Gina M. Leinninger, Carey Backus, Ann Marie Sastry, Yun-Bo Yi, Chia-Wei Wang, Eva L. Feldman   +5 more
doaj   +1 more source

Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1 [PDF]

Animal Cells and Systems, 2018
Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation system.
openaire   +3 more sources

Mitochondrial dysfunction in cardiovascular disease: investigating therapeutic approaches to enhance patient outcomes

MGM Journal of Medical Sciences
Mitochondria, the energy-generating organelles, undergo continuous biosynthesis, fission, fusion, and degradation cycles to maintain structural integrity.
Omar Elsaka
doaj   +1 more source

Neurotrophins induce fission of mitochondria along embryonic sensory axons

eLife, 2019
Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial
Lorena Armijo-Weingart, Andrea Ketschek, Rajiv Sainath, Almudena Pacheco, George M Smith, Gianluca Gallo   +5 more
doaj   +1 more source

Mitochondrial fission and fusion in inflammatory diseases: mechanisms and therapeutic implications

Journal of Translational Medicine
Background Mitochondrial fission and fusion are dynamic and highly regulated processes that are essential for maintaining cellular homeostasis. These processes are regulated by core proteins, including dynamin-related protein 1 (DRP1), fission 1 protein (
Wenjing Xu, Xinru Xu, Yaonan Zhang, Fenfen Li, Daozong Xia   +4 more
doaj   +1 more source

Quantifying the inhibitory effect of Bcl‐xl on the action of Mff using live‐cell fluorescence imaging

FEBS Open Bio, 2019
Mitochondrial fission regulates mitochondrial function and morphology, and has been linked to apoptosis. The mitochondrial fission factor (Mff), a tail‐anchored membrane protein, induces excessive mitochondrial fission, contributing to mitochondrial ...
Yunyun Ma, Mengyan Du, Fangfang Yang, Zihao Mai, Chenshuang Zhang, Wenfeng Qu, Bin Wang, Xiaoping Wang, Tongsheng Chen   +8 more
doaj   +1 more source