Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
PLoS Biology, 2020 Although dysregulation of mitochondrial dynamics has been linked to cellular senescence, which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 (Klf5), an essential transcriptional factor of cardiovascular remodeling,
Dong Ma +9 more
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Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1 [PDF]
Biochemical and Biophysical Research Communications, 2018 Undifferentiated odontogenic epithelium and dental papilla cells differentiate into ameloblasts and odontoblasts, respectively, both of which are essential for tooth development. These differentiation processes involve dramatic functional and morphological changes of the cells.
Yumiko I. Matsuishi +8 more
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Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis
Signal Transduction and Targeted Therapy, 2021 Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network ...
Yan Yu +20 more
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Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1 [PDF]
Genes to Cells, 2012 Mtf1 has been characterized as a mitochondrial transcription factor and is shown to regulate mitochondrial transcription. Mtf1 has an additional function as a transcription factor for the nuclear gene srk1 in fission yeast. Hsp60 has been linked to a variety of important cellular functions such as apoptosis and the immune response.
Wenxia, Sun +4 more
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T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor [PDF]
Cell Death & Differentiation, 2016 Mitochondrial morphology is dynamically regulated by the formation of small fragmented units or interconnected mitochondrial networks, and this dynamic morphological change is a pivotal process in normal mitochondrial function. In the present study, we identified a novel regulator responsible for the regulation of mitochondrial dynamics. An assay using
Hyosun, Tak +12 more
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Particle and Fibre Toxicology, 2023 Background Exposure to particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is a risk factor for developing pulmonary diseases and the worsening of ongoing disease.
Qi Liu +12 more
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Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy
Endocrine Connections, 2019 Aims: Previous studies showed that abnormal mitochondrial structure and function were involved in the pathological process of diabetic nephropathy (DN). The dynamic mitochondrial processes, including fusion and fission, maintain the mass and quantity of ...
Yiqiong Ma +6 more
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Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie,
Nicole L. Mancini +14 more
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KLF6 aggravates myocardial fibrosis by promoting mitochondrial division
Pakistan Journal of Pharmaceutical SciencesThe dysregulation of mitochondrial dynamics in cardiac fibroblasts (CFs) is closely linked to myocardial fibrosis, which can induce cardiac dysfunction and even lead to heart failure.
Tingting Zhang +4 more
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C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage
Frontiers in Pharmacology, 2019 Mitochondrial dysfunction is a predominant risk factor in ischemic heart disease, in which the imbalance of mitochondrial fusion and fission deteriorates mitochondrial function and might lead to cardiomyocyte death.
Jinchao Gao +9 more
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